Hidehiko Shogomori,Deborah A Brown
Hidehiko Shogomori
Eukaryotic cell membranes contain microdomains called lipid rafts, which are cholesterol-rich domains in which lipid acyl chains are tightly packed and highly extended. A variety of proteins associate preferentially with rafts, and this raf...
Qais Al-Awqati,Soundaraparan Vijayakumar,Jiro Takito
Qais Al-Awqati
All epithelia form sheets of cells connected by tight and adherent junctions and exhibit polarized distribution of membrane proteins and lipids. During their development, epithelia progress from this 'generic' phenotype to terminally differ...
F Ulrich Hartl
F Ulrich Hartl
Clinical relevance of matrix metalloproteinase-13 determined with a new highly specific and sensitive ELISA in ascitic fluid of advanced ovarian carcinoma patients [0.03%]
一种新的基质金属蛋白酶-13检测方法及其在晚期卵巢癌患者腹水中临床意义的探讨
Bernd Hantke,Nadia Harbeck,Barbara Schmalfeldt et al.
Bernd Hantke et al.
Matrix metalloproteinases (MMPs) are involved in many physiological and pathophysiological processes, including tumor cell invasion and metastasis. For one member of this family, MMP-13 (collagenase-3), a new, highly specific ELISA with a s...
Novel cell-permeable acyloxymethylketone inhibitors of asparaginyl endopeptidase [0.03%]
新型细胞穿透型酰氧甲基酮类型的天冬氨酰内肽酶抑制剂
Kylie Loak,Dongtao Ni Li,Bénédicte Manoury et al.
Kylie Loak et al.
Mammalian asparaginyl endopeptidase (AEP) or legumain is a recently identified lysosomal cysteine protease belonging to clan CD. To date it has been shown to be involved in antigen presentation within class II MHC positive cells and in pro-...
The N'-terminal domain of glyceraldehyde-3-phosphate dehydrogenase of the apicomplexan Plasmodium falciparum mediates GTPase Rab2-dependent recruitment to membranes [0.03%]
恶性疟原虫甘油醛-3-磷酸脱氢酶N末端调控其以Rab2依赖方式募集到膜上
Claudia A Daubenberger,Ellen J Tisdale,Marija Curcic et al.
Claudia A Daubenberger et al.
Spatial and temporal distribution of the glycolytic enzymes glyceraldehyde-3-phosphate dehydrogenase (pfGAPDH) and aldolase (pfAldolase) of Plasmodium falciparum were investigated using specific mAbs and indirect immunofluorescence analysis...
EGFR and FGFR signaling through FRS2 is subject to negative feedback control by ERK1/2 [0.03%]
ERK1/2可以通过MAP4K3负反馈调控EGFR和FGFR信号通路中的FRS2
Yingjie Wu,Zhengjun Chen,Axel Ullrich
Yingjie Wu
Fibroblast growth factor (FGF) receptor substrate 2 (FRS2) is a membrane-anchored docking protein that has been shown to play an important role in linking FGF, nerve growth factor (NGF) and glial cell-derived neurotrophic factor (GDNF) rece...
Trans-sialidase-like sequences from Trypanosoma congolense conserve most of the critical active site residues found in other trans-sialidases [0.03%]
恶性锥虫特有转唾液酸酶样序列的鉴定及分析
Evelin Tiralongo,Ilka Martensen,Joachim Grötzinger et al.
Evelin Tiralongo et al.
Trypanosoma congolense is the agent of Nagana, the trypanosomiasis in African ruminants. Trypanosomes express an enzyme called trans-sialidase, which is believed to play an important role in maintaining pathogenicity of the parasites. Thus ...
The activator-binding site of Onchocerca volvulus S-adenosylmethionine decarboxylase, a potential drug target [0.03%]
旋毛虫S-腺苷甲硫氨酸脱羧酶的作用位点及潜在药物靶标性质研究
Dieudonne Ndjonka,Yu Zou,Xiangdong Bi et al.
Dieudonne Ndjonka et al.
S-Adenosylmethionine decarboxylase (AdoMetDC) is a key enzyme in polyamine biosynthesis. In many eukaryotes its activity is stimulated specifically by putrescine. The AdoMetDC of the filarial parasite Onchocerca volvulus, however, is not on...
The molecular chaperone, alpha-crystallin, protects against loss of antigenicity and activity of esterase caused by sugars, sugar phosphate and a steroid [0.03%]
糖、糖磷酸盐和类固醇引起的酯酶抗原性的丧失及活性的损害可被分子伴侣α-晶体蛋白所保护
Hong Yan,John J Harding
Hong Yan
Previously we showed that glycation-induced inactivation and loss of antigenicity of enzymes occur simultaneously. Alpha-crystallin, a major structural protein of the mammalian lens, prevents the aggregation of other proteins and protects e...