HIV TAT basic peptide is not a high-affinity ligand for VEGF receptor 2 [0.03%]
HIV-TAT基序并不是血管内皮生长因子受体2的高亲和力配体
Alma Rubio Demirovic,Jasna Canadi,Wolfgang Weiglhofer et al.
Alma Rubio Demirovic et al.
The 'transactivator of transcription' (TAT) protein of human immunodeficiency virus transforms cells in culture and promotes the development of tumors, so-called Kaposi's sarcoma, in AIDS patients. TAT induces growth and differentiation of ...
Benqiong Xiang,Ping Liu,Guohua Jiang et al.
Benqiong Xiang et al.
Calcineurin (CaN) is a heterodimer composed of a catalytic subunit A (CaNA) and a regulatory subunit B (CaNB). We report here an active truncated mutation of the rat CaNAdelta that contains only the catalytic domain (residues 1-347, also kn...
Transcription of cathepsin B in glioma cells: regulation by an E-box adjacent to the transcription initiation site [0.03%]
胶质瘤细胞中组织蛋白酶B的转录：由起始位点附近的E盒调节
Shiqing Yan,Derek T Jane,Michael J Dufresne et al.
Shiqing Yan et al.
We have previously isolated the human cathepsin B promoter and shown that Sp1 and Ets factors are involved in the regulation of cathepsin B expression. Using mutagenesis, transient transfection and electrophoretic mobility shift assays (EMS...
Ada Yonath
Ada Yonath
In the ribosome, the decoding and peptide bond formation sites are composed entirely of ribosomal RNA, thus confirming that the ribosome is a ribozyme. Precise alignment of the aminoacylated and peptidyl tRNA 3'-ends, which is the major enz...
Jaroslaw Czyz,Cornelia Wiese,Alexandra Rolletschek et al.
Jaroslaw Czyz et al.
Recent developments in the field of stem cell research indicate their enormous potential as a source of tissue for regenerative therapies. The success of such applications will depend on the precise properties and potentials of stem cells i...
Nitric oxide signalling with a special focus on lipid-derived mediators [0.03%]
一氧化氮信号转导及以脂衍生物调节剂为重点的研究
Andrea Huwiler,Josef Pfeilschifter
Andrea Huwiler
The ways in which cells communicate among each other concerns all aspects of biology, from developmental processes to diseases. Nitric oxide (NO) is one of the most remarkable and unusual regulatory molecules. It is a labile free radical ga...
Klaus-Dietrich Kröncke
Klaus-Dietrich Kröncke
Low NO concentrations synthesized by constitutively expressed NO synthases act on several signaling pathways activating transcription factors (TF), such as NF-kappaB or AP-1, and thereby influence gene expression. In contrast, during inflam...
Hartmut Kleinert,Petra M Schwarz,Ulrich Förstermann
Hartmut Kleinert
Nitric oxide (NO), generated by the inducible isoform of nitric oxide synthase (iNOS), has been described to have beneficial microbicidal, antiviral, antiparasital, immunomodulatory, and antitumoral effects. However, aberrant iNOS induction...
Klaus-Dietrich Kröncke
Klaus-Dietrich Kröncke
Nitridergic platelet pathway activation by hementerin, a metalloprotease from the leech Haementeria depressa [0.03%]
Ana M Chudzinski-Tavassi,Emilse Bermej,Ruth E Rosenstein et al.
Ana M Chudzinski-Tavassi et al.
Hementerin (HT) is an 80 kDa fibrino(geno)lytic metalloprotease, purified from saliva of the leech Haementeria depressa. In the present report, the effect of HT on several functional parameters of human platelets was assessed. HT inhibited ...