Induction of lipoprotein lipase gene expression in Chlamydia pneumoniae-infected macrophages is dependent on Ca2+ signaling events [0.03%]
肺炎衣原体感染的巨噬细胞中脂蛋白脂酶基因表达的诱导依赖于钙信号事件
Anthony A Azenabor,Godwin Job,Shoua Yang
Anthony A Azenabor
Unregulated uptake of low density lipoprotein (LDL) in macrophages is the hallmark of early atherogenic lesions, and Chlamydia pneumoniae infection of macrophages induces this process by an unknown mechanism. It was therefore aimed in this ...
Anil K Chava,Mitali Chatterjee,Gerrit J Gerwig et al.
Anil K Chava et al.
The presence of Neu5Ac on promastigotes of Leishmania donovani, the causative organism of Indian visceral leishmaniasis, has been reported recently. Here we report the occurrence of Neu5Ac as a major component on amastigotes, as well as Neu...
N-linked glycosylation of the human bradykinin B2 receptor is required for optimal cell-surface expression and coupling [0.03%]
N连接糖基化是人缓激肽B2受体最佳细胞表面表达和偶联的必要条件
Stéphanie Michineau,Laurent Muller,Anne Pizard et al.
Stéphanie Michineau et al.
To investigate the glycosylation of the human bradykinin B2 receptor and the functional significance of this modification, we studied receptors mutated at single or multiple combinations of the three potential N-linked glycosylation sites, ...
Relevance of the kinetic equilibrium of forces to the control of the cell cycle by Ras proteins [0.03%]
Ras蛋白调控细胞周期的力的平衡的意义
Erwin W Becker
Erwin W Becker
In higher organisms, the replacement of GDP bound to Ras proteins with GTP, under the participation of an exchange factor, is an important step in the initiation of cell division. Ras-GTP activates kinases and other effectors, which pass si...
Structural destabilization of the recombinant thermophilic TthL11 ribosomal protein by a single amino acid substitution [0.03%]
嗜热 Thermophilic TthL11 核糖体蛋白单氨基酸取代后的构象不稳定性分析
Dimitra Triantafillidou,Eleutheria Persidou,Despina Lazarou et al.
Dimitra Triantafillidou et al.
Thermus thermophilus L11 protein has previously been reported to be resistant against tryptic and chymotryptic proteolysis under native conditions. With a single amino acid substitution, namely Trp101Arg, conformational changes were induced...
Functional studies on the ligand-binding domain of Ultraspiracle from Drosophila melanogaster [0.03%]
模式节肢动物中Ultraspiracle蛋白配体结合域的功能研究
Sabina Przibilla,William W Hitchcock,Mihaly Szécsi et al.
Sabina Przibilla et al.
The functional insect ecdysteroid receptor is comprised of the ecdysone receptor (EcR) and Ultraspiracle (USP). The ligand-binding domain (LBD) of USP was fused to the GAL4 DNA-binding domain (GAL4-DBD) and characterized by analyzing the ef...
Singlet oxygen-mediated damage to cellular DNA determined by the comet assay associated with DNA repair enzymes [0.03%]
单线态氧导致的细胞DNA损伤及连接酶相关的彗星测定法检测
Jean-Luc Ravanat,Sylvie Sauvaigo,Sylvain Caillat et al.
Jean-Luc Ravanat et al.
The damage profile produced by the reaction of singlet molecular oxygen with cellular DNA was determined using the comet assay associated with DNA repair enzymes. Singlet oxygen was produced intracellularly by thermal decomposition of a wat...
'Til cell death do us part: nitric oxide and mechanisms of hepatotoxicity [0.03%]
“直到细胞死亡——硝基氧化物和肝毒性机制》
Peter K M Kim,Brian S Zuckerbraun,Leo E Otterbein et al.
Peter K M Kim et al.
Like many juggernauts in biology, the elusive nature of nitric oxide (NO) sprints through the fields, sometimes the savior, at other times the scimitar. In the liver, which is the metabolic center of the organism, hepatocytes and immune cel...
The chemistry of nitrosative stress induced by nitric oxide and reactive nitrogen oxide species. Putting perspective on stressful biological situations [0.03%]
由一氧化氮和反应性亚硝基氧化物引发的硝基化压力的化学原理。对生物体处于压力状态下的情况的一些见解
Lisa A Ridnour,Douglas D Thomas,Daniele Mancardi et al.
Lisa A Ridnour et al.
This review addresses many of the chemical aspects of nitrosative stress mediated by N2O3. From a cellular perspective, N2O3 and the resulting reactive nitrogen oxide species target specific motifs such as thiols, lysine active sites, and z...
Semisynthesis and application of carboxyfluorescein-labelled biologically active human interleukin-8 [0.03%]
人生物活性白介素8的半合成及羧基荧光素标记物的应用
Ralf David,Zuzana Machova,Annette G Beck-Sickinger
Ralf David
Human interleukin 8 (hIL-8), a neutrophil-activating and chemotactic cytokine, is known to play an important role in the pathogenesis of a large number of neutrophil-driven inflammatory diseases. This cytokine belongs to the family of CXC c...