Isoaspartate residues dramatically influence substrate recognition and turnover by proteases [0.03%]
异天门冬氨酸残基显著影响蛋白酶对底物的识别和降解
Livia Böhme,Joachim Wolfgang Bär,Torsten Hoffmann et al.
Livia Böhme et al.
Posttranslational modifications influence the structure, stability and biological activity of proteins. Most of the reactions are enzyme-catalyzed, but some, such as asparagine (Asn) and glutamine (Gln) deamidation and the isoaspartate (iso...
Cancer cells, adipocytes and matrix metalloproteinase 11: a vicious tumor progression cycle [0.03%]
癌细胞、脂肪细胞和基质金属蛋白酶11：恶性肿瘤进展循环
Elena Roza Motrescu,Marie-Christine Rio
Elena Roza Motrescu
This brief review focuses on the emerging role of matrix metalloproteinase 11 (MMP-11) in cancer progression. It has recently been shown that MMP-11 is induced in adipose tissue by cancer cells as they invade their surrounding environment. ...
How Na+ activates thrombin--a review of the functional and structural data [0.03%]
钠离子活化凝血酶的功能和结构数据的综述
James A Huntington
James A Huntington
Thrombin is the ultimate coagulation factor; it is the final protease generated in the blood coagulation cascade and is the effector of clot formation. Regulation of thrombin activity is thus of great relevance to determining the correct ha...
Angiotensin-converting enzyme limits inflammation elicited by Trypanosoma cruzi cysteine proteases: a peripheral mechanism regulating adaptive immunity via the innate kinin pathway [0.03%]
血管紧张素转化酶限制由克氏锥虫半胱氨酸蛋白酶引起的炎症：通过先天性激肽途径调节适应性免疫的外周机制
Julio Scharfstein,Ana Carolina Monteiro,Veronica Schmitz et al.
Julio Scharfstein et al.
Tissue injury by pathogens induces a stereotyped inflammatory response that alerts the innate immune system of the potential threat to host integrity. Here, we review knowledge emerging from investigations of the role of the kinin system in...
Alternative pathways for production of beta-amyloid peptides of Alzheimer's disease [0.03%]
产生阿尔茨海默病β淀粉样蛋白肽的替代途径
Vivian Hook,Israel Schechter,Hans-Ulrich Demuth et al.
Vivian Hook et al.
This highlight article describes three Alzheimer's disease (AD) studies presented at the 5th General Meeting of the International Proteolysis Society that address enzymatic mechanisms for producing neurotoxic beta-amyloid (Abeta) peptides. ...
Glutaminyl cyclases from animals and plants: a case of functionally convergent protein evolution [0.03%]
动物和植物的谷氨酰胺环化酶：功能趋同蛋白质进化的一个例子
Stephan Schilling,Claus Wasternack,Hans-Ulrich Demuth
Stephan Schilling
Several mammalian peptide hormones and proteins from plant and animal origin contain an N-terminal pyroglutamic acid (pGlu) residue. Frequently, the moiety is important in exerting biological function in either mediating interaction with re...
Proteinases as hormones: targets and mechanisms for proteolytic signaling [0.03%]
蛋白酶作为激素：蛋白酶信号转导的作用靶点和机制
Kristina K Hansen,Katerina Oikonomopoulou,Amos Baruch et al.
Kristina K Hansen et al.
Proteinases, such as kallikrein-related peptidases, trypsin and thrombin, can play hormone-like 'messenger roles in vivo. They can regulate cell signaling by cleaving and activating a novel family of G-protein-coupled proteinase-activated r...
Modeling of variant copies of subunit D1 in the structure of photosystem II from Thermosynechococcus elongatus [0.03%]
天冬杆菌II类光系统II复合物D1亚基变异体的建模研究
Bernhard Loll,Matthias Broser,Peter B Kós et al.
Bernhard Loll et al.
In the cyanobacterium Thermosynechococcus elongatus BP-1, living in hot springs, the light environment directly regulates expression of genes that encode key components of the photosynthetic multi-subunit protein-pigment complex photosystem...
Sayan Gupta,Shyamalava Mazumdar
Sayan Gupta
The enzymatic activity of Paracoccus denitrificans cytochrome c oxidase (COX) and Escherichia coli cytochrome b(o) ubiquinol oxidase (QOX) was determined in the presence of formamide, N,N-dimethyl formamide and N,N-dimethyl acetamide. Forma...
Stefano Marzi,Pierre Fechter,Clément Chevalier et al.
Stefano Marzi et al.
A large variety of RNA-based mechanisms have been uncovered in all living organisms to regulate gene expression in response to internal and external changes, and to rapidly adapt cell growth in response to these signals. In bacteria, struct...