Biochemical analysis of neutral endopeptidase activity reveals independent catabolism of atrial and brain natriuretic peptide [0.03%]
生化分析中的中性内肽酶活性独立分解心房和脑利钠肽
Thomas Walther,Holger Stepan,Kristin Pankow et al.
Thomas Walther et al.
Recent reports presented contradictory results regarding the catabolism of mature atrial (ANP) and brain (BNP) natriuretic peptides in circulation. Especially the role of neutral endopeptidase (NEP) in BNP degradation was conversely discuss...
Degradation, receptor binding, insulin secreting and antihyperglycaemic actions of palmitate-derivatised native and Ala8-substituted GLP-1 analogues [0.03%]
棕榈酸修饰的胰高血糖素样肽-1(GLP-1)类似物的降解、受体结合、促胰岛素分泌和抗高血糖作用：阿拉8取代的GLP-1类似物
Brian D Green,Victor A Gault,Mark H Mooney et al.
Brian D Green et al.
The hormone glucagon-like peptide-1(7-36)amide (GLP-1) is released in response to ingested nutrients and acts to promote glucose-dependent insulin secretion ensuring efficient postprandial glucose homeostasis. Unfortunately, the beneficial ...
Increased expression of Apaf-1 and procaspase-3 and the functionality of intrinsic apoptosis apparatus in non-small cell lung carcinoma [0.03%]
非小细胞肺癌中Apaf-1和procaspase-3表达增强及凋亡装置功能的研究
Evzen Krepela,Jan Procházka,Xiaoyi Liul et al.
Evzen Krepela et al.
The intrinsic apoptosis apparatus plays a significant role in generating and amplifying cell death signals. In this study we examined whether there are differences in the expression of its components and in its functioning in non-small cell...
Comparative Study
Biological chemistry. 2004 Feb;385(2):153-68. DOI:10.1515/BC.2004.034 2004
Yanqin Shen,Joe Tiralongo,Guido Kohla et al.
Yanqin Shen et al.
The expression of O-acetylated sialic acids in human colonic mucins is developmentally regulated, and a reduction of O-acetylation has been found to be associated with the early stages of colorectal cancer. Despite this, however, little is ...
The periplasmic E. coli chaperone Skp is a trimer in solution: biophysical and preliminary crystallographic characterization [0.03%]
E.coli周质分子伴侣Skp的溶液结构为三聚体：生物物理和初步结晶学研究
Martin Schlapschy,Monica K Dommel,Kamyar Hadian et al.
Martin Schlapschy et al.
The 'seventeen kilodalton protein' Skp confers transient solubility on outer membrane proteins during biogenesis in Gram-negative bacteria. Here we report a first biophysical characterization of this chaperone itself, which also possesses b...
The urokinase receptor (uPAR) and the uPAR-associated protein (uPARAP/Endo180): membrane proteins engaged in matrix turnover during tissue remodeling [0.03%]
尿激酶受体（uPAR）和uPAR相关蛋白（uPARAP/Endo180）：在组织重塑期间参与基质更新的膜蛋白
Niels Behrendt
Niels Behrendt
The breakdown of the barriers formed by extracellular matrix proteins is a pre-requisite for all processes of tissue remodeling. Matrix degradation reactions take part in specific physiological events in the healthy organism but also repres...
Christian Klein,Friederike Hesse,Alexander Dehner et al.
Christian Klein et al.
The transcription factor p53 acts as major tumor suppressor and is inactivated by mutation in more than 50% of all human tumors. We have established an efficient procedure for the in vitro folding and purification of the p53 DNA binding dom...
Monitoring human parvovirus B19 virus-like particles and antibody complexes in solution by fluorescence correlation spectroscopy [0.03%]
利用荧光相关光谱技术监测溶液中人细小病毒B19病毒样颗粒及抗体复合物
Jouni Toivola,Patrik O Michel,Leona Gilbert et al.
Jouni Toivola et al.
Fluorescence correlation spectroscopy (FCS) was used in monitoring human parvovirus B19 virus-like particle (VLP) antibody complexes from acute phase and past-immunity serum samples. The Oregon Green 488-labeled VLPs gave an average diffusi...
Induction of MMP-10 and MMP-1 in a squamous cell carcinoma cell line by ultraviolet radiation [0.03%]
紫外线诱导鳞状细胞癌系中基质金属蛋白酶MMP-10和MMP-1的表达
Maria C Ramos,Holger Steinbrenner,Dominik Stuhlmann et al.
Maria C Ramos et al.
Ultraviolet radiation may cause non-melanoma skin cancer by genetic and epigenetic events. In this study, we investigated in a squamous cell carcinoma cell line, SCL-1, whether UV irradiation modulates the expression of matrix metalloprotei...