Norbert Weissmann,Henrik Vogels,Ralph T Schermuly et al.
Norbert Weissmann et al.
Exhaled H2O2 is considered an indicator of lung inflammatory and oxidative stress. Moreover, H2O2 may be involved in signal transduction processes. It is not fully elucidated to what extent (i) H2O2 escapes from the intravascular compartmen...
Comparative Study
Biological chemistry. 2004 Mar-Apr;385(3-4):259-64. DOI:10.1515/BC.2004.020 2004
Redox-sensitive regulation of the HIF pathway under non-hypoxic conditions in pulmonary artery smooth muscle cells [0.03%]
缺氧条件下红氧化状态调节肺动脉平滑肌细胞HIF信号通路的新机制研究
Rachida S BelAiba,Talija Djordjevic,Steve Bonello et al.
Rachida S BelAiba et al.
Pulmonary hypertension and vascular remodeling processes are associated with oxidative stress, hypoxia and enhanced levels of thrombin and vascular endothelial growth factor (VEGF). The hypoxia-inducible transcription factor HIF regulates t...
Modulation of glucokinase expression by hypoxia-inducible factor 1 and upstream stimulatory factor 2 in primary rat hepatocytes [0.03%]
缺氧诱导因子1和上游刺激因子2对初级原代培养大鼠肝细胞葡萄糖激酶表达的调节作用
Ulrike Roth,Kurt Jungermann,Thomas Kietzmann
Ulrike Roth
Glucokinase (GK) is the key enzyme of glucose utilization in liver and is localized in the less aerobic perivenous area. Until now, the O2-responsive elements in the liver-specific GK promoter are unknown, and therefore the aim of this stud...
Visualization of the three-dimensional organization of hypoxia-inducible factor-1 alpha and interacting cofactors in subnuclear structures [0.03%]
低氧诱导因子-1α及其相互作用辅因子在亚核结构中的三维组织可视化
Utta Berchner-Pfannschmidt,Christoph Wotzlaw,Evelyne Merten et al.
Utta Berchner-Pfannschmidt et al.
Cells need oxygen (O2) to meet their metabolic demands. Highly efficient systems of O2-sensing have evolved to initiate responses enabling cells to adapt their metabolism to reduced O2 availability. Of central importance is the activation o...
Eric Metzen,Peter J Ratcliffe
Eric Metzen
Hypoxia-inducible factor (HIF) is a transcriptional complex that mediates a broad range of cellular and systemic responses to hypoxia. Analysis of HIF-alpha subunits has demonstrated that its activity is regulated by a series of oxygen-depe...
Oxidative stress in the systemic and cellular responses to intermittent hypoxia [0.03%]
间断性低氧暴露的系统及细胞反应中的氧化应激作用
Nanduri R Prabhakar,Ganesh K Kumar
Nanduri R Prabhakar
Patients with chronic intermittent hypoxia (IH) caused by recurrent apneas have a greatly increased risk for developing hypertension, myocardial infarctions, and stroke. The purpose of this article is to highlight some of the recent studies...
O2 sensing in the human ductus arteriosus: redox-sensitive K+ channels are regulated by mitochondria-derived hydrogen peroxide [0.03%]
人动脉导管中的O2感受：由线粒体产生的氢过氧化物调节的红氧素敏感性的K+通道
Stephen L Archer,Xi-Chen Wu,Bernard Thébaud et al.
Stephen L Archer et al.
The ductus arteriosus (DA) is a fetal artery that allows blood ejected from the right ventricle to bypass the pulmonary circulation in utero. At birth, functional closure of the DA is initiated by an O2-induced, vasoconstrictor mechanism wh...
Oxygen and the cell [0.03%]
氧与细胞
Joachim Fandrey
Joachim Fandrey
Probing the role of tryptophans in Aequorea victoria green fluorescent proteins with an expanded genetic code [0.03%]
利用扩增的遗传密码研究维多利亚绿荧光蛋白中的色氨酸作用
Nediljko Budisa,Prajna Paramita Pal,Stefan Alefelder et al.
Nediljko Budisa et al.
The expanded genetic code in combination with site-directed mutagenesis was used to probe spectroscopic and structural roles of tryptophan (Trp) residues in Aequorea victoria green fluorescent proteins (avGFPs). Nine different halogen-, cha...
First report on a potato I family chymotrypsin inhibitor from the seeds of a Cucurbitaceous plant, Momordica cochinchinensis [0.03%]
从植物Momordica cochinchinensis的种子中首次获得I家族土豆胰凝乳蛋白酶抑制剂报告
Alex Y K Tsoi,Ricardo C H Wong,Tzi-Bun Ng et al.
Alex Y K Tsoi et al.
A 7514-Da chymotrypsin inhibitor was isolated from the seed extract of Momordica cochinchinensis (Family Cucurbitaceae) by chromatography on chymotrypsin-Sepharose 4B and subsequently by C18 reversed-phase HPLC. This inhibitor, named MCoCl,...