Critical O2 and NO concentrations in NO-induced cell death in a rat liver sinusoidal endothelial cell line [0.03%]
NO诱导的大鼠肝窦内皮细胞系 Critical O2和NO浓度
Nathalie Dehne,Tongju Li,Frank Petrat et al.
Nathalie Dehne et al.
Nitric oxide (NO) plus oxygen (O2) are known to cause cell damage via formation of reactive nitrogen species. NO itself directly inhibits cytochrome oxidase of the mitochondrial respiratory chain in competition with O2, thus inducing a hypo...
Comparative Study
Biological chemistry. 2004 Mar-Apr;385(3-4):341-9. DOI:10.1515/BC.2004.030 2004
Enhanced expression of basolateral multidrug resistance protein isoforms Mrp3 and Mrp5 in rat liver by LPS [0.03%]
LPS诱导的大鼠肝胆基底侧膜多药耐药蛋白异构体Mrp3和Mrp5表达增强
Markus G Donner,Ulrich Warskulat,Nirmalendu Saha et al.
Markus G Donner et al.
Lipopolysaccharide (LPS) induces hepatocellular down-regulation and endocytic retrieval of multidrug resistance protein 2 (Mrp2, Abcc2). Basolateral Mrp isoforms may compensate for the intracellular metabolic changes in cholestasis. Therefo...
Inhibition of lentil copper/TPQ amine oxidase by the mechanism-based inhibitor derived from tyramine [0.03%]
秋水仙素铜/TPQ胺氧化酶通过来源于酪氨的基于机制抑制剂抑制作用
Alessandra Padiglia,Giovanni Floris,Silvia Longu et al.
Alessandra Padiglia et al.
Copper amine oxidase from lentil (Lens esculenta) seedlings was shown to catalyze the oxidative deamination of tyramine and three similar aromatic monoamines, benzylamine, phenylethylamine and 4-methoxyphenylethylamine. Tyramine, an importa...
Skin secretion of the toad Bombina variegata contains multiple insulin-releasing peptides including bombesin and entirely novel insulinotropic structures [0.03%]
东方铃蟾皮肤提取物含多种促胰岛素释放多肽包括燕鹤刺激素及全新促胰岛素生成结构体
Lamin Marenah,Peter R Flatt,David F Orr et al.
Lamin Marenah et al.
Skin secretions of the toad Bombina variegata were evaluated for the isolation and characterisation of insulinotropic peptides. Crude secretions obtained from young adult toads by mild electrical stimulation of the dorsal skin surface were ...
Comparative Study
Biological chemistry. 2004 Mar-Apr;385(3-4):315-21. DOI:10.1515/BC.2004.027 2004
The central domain of the matrix protein of HIV-1: influence on protein structure and virus infectivity [0.03%]
人类免疫缺陷病毒Ⅰ型的基质蛋白的核心区域对其蛋白结构及病毒感染性的影响研究
Anja-Daniela Ellenrieder,Werner Kremer,Bernhard Kattenbeck et al.
Anja-Daniela Ellenrieder et al.
The central region of the matrix protein p17 of HIV-1 is known to be essential during virus assembly. We substituted alanines for amino acid triplets in this region of p17 (amino acid residues 47 to 55: NPG LLE TSE). Introduction of the res...
Cibele C Cardoso,Tawana Garrett,Cécile Cayla et al.
Cibele C Cardoso et al.
Kininogens serve dual functions by forming a scaffold for the assembly of the protein complex initiating the surface-activated blood coagulation cascade and as precursors for the kinin hormones. While rats have three kininogen genes, for mi...
Comparative Study
Biological chemistry. 2004 Mar-Apr;385(3-4):295-301. DOI:10.1515/BC.2004.025 2004
Simultaneous exposure of rats to dioxin and carbon monoxide reduces the xenobiotic but not the hypoxic response [0.03%]
同时暴露于大鼠的二恶英和一氧化碳降低了外源性但不是低氧反应
Thomas Hofer,Raimo Pohjanvirta,Patrick Spielmann et al.
Thomas Hofer et al.
Aryl hydrocarbon receptor (AhR) and hypoxia-inducible factor-1alpha (HIF-1alpha) are conditionally regulated transcription factor subunits that form heterodimeric complexes with their common partner, AhR nuclear translocator (ARNT/HIF-1beta...
Remodelling of Ca2+ homeostasis in type I cortical astrocytes by hypoxia: evidence for association with Alzheimer's disease [0.03%]
低氧重塑I型皮质星形胶质细胞Ca2+稳态及与阿尔茨海默病的关系
Chris Peers,Ian F Smith,John P Boyle et al.
Chris Peers et al.
Sustained central hypoxia predisposes individuals to dementias such as Alzheimer's disease, in which cells are destroyed in part by disruption of Ca2+ homeostasis. Here, we show that exposure of astrocytes to hypoxia in vitro causes inhibit...
Expression of functional purinergic receptors in pulmonary neuroepithelial bodies and their role in hypoxia chemotransmission [0.03%]
肺神经上皮体中功能性的嘌呤受体的表达及其在低氧化学信号传递中的作用
Xiao Wen Fu,Colin A Nurse,Ernest Cutz
Xiao Wen Fu
Adenine nucleotides act through specific cell surface receptors to invoke a variety of biological responses. Here we show that cells of neuroepithelial bodies (NEB), presumed O2 airway sensors in neonatal hamster lung, express functional P2...
Effects of reducing agents on glutathione metabolism and the function of carotid body chemoreceptor cells [0.03%]
还原剂对谷胱甘肽代谢和颈动脉体化学感受器细胞功能的影响
Constancio Gonzalez,Gloria Sanz-Alyayate,M Teresa Agapito et al.
Constancio Gonzalez et al.
Two current hypotheses of O2 sensing in the carotid body (CB) chemoreceptors suggest participation of oxygen reactive (ROS) species, but they are mechanistically opposed. One postulates that hypoxia decreases ROS levels; the other that hypo...
Comparative Study
Biological chemistry. 2004 Mar-Apr;385(3-4):265-74. DOI:10.1515/BC.2004.021 2004