Cell type-dependent release of nitric oxide and/or reactive nitrogenoxide species from intracellular SIN-1: effects on cellular NAD(P)H [0.03%]
细胞内SIN-1释放一氧化氮和/或反应性氮氧物质的类型依赖性：对细胞内NAD(P)H的影响
Andrea U Swintek,Sandra Christoph,Frank Petrat et al.
Andrea U Swintek et al.
SIN-1 is frequently used in cell culture studies as an extracellularly operating generator of peroxynitrite. However, little is known about the nature of the reactive species produced intracellulary from SIN-1. SIN-1 can easily penetrate ce...
Inactivation of protein disulfide isomerase by alkylators including alpha,beta-unsaturated aldehydes at low physiological pHs [0.03%]
生理低pH值下的蛋白二硫异构酶烷基化失活包括α,β-不饱和甲醛的作用机制研究
Xi-Wen Liu,Dai-Eun Sok
Xi-Wen Liu
Protein disulfide isomerase (PDI) is known to contain the thioredoxin box motif with a low pKa cysteine residue. To investigate the reactivity of PDI with thiol modifiers at low physiological pHs, either the reduced (PDIred) or oxidized for...
Metal-responsive transcription factor-1 (MTF-1) selects different types of metal response elements at low vs. high zinc concentration [0.03%]
低锌和高锌浓度下金属应答因子-1(MTF-1)选择不同的金属底物元件类型
Ying Wang,Iris Lorenzi,Oleg Georgiev et al.
Ying Wang et al.
Metal-responsive transcription factor-1 (MTF-1) is a zinc finger protein with a central role in heavy metal homeostasis/detoxification. MTF-1 binds to DNA sequence motifs known as metal response elements (MREs) with a core consensus TGCRCNC...
Petra Böck-Taferner,Herbert Wank
Petra Böck-Taferner
Group II introns are autocatalytic RNAs which self-splice in vitro. However, in vivo additional protein factors might be involved in the splicing process. We used an affinity chromatography method called 'StreptoTag' to identify group II in...
All-trans retinoic acid-responsive genes identified in the human SH-SY5Y neuroblastoma cell line and their regulated expression in the nervous system of early embryos [0.03%]
全反式维甲酸应答基因在人类神经母细胞瘤SH-SY5Y细胞系中的鉴定及其在早期胚胎神经系统中表达的调节
Ronald A Merrill,Jamie M Ahrens,Mary E Kaiser et al.
Ronald A Merrill et al.
The vitamin A metabolite, all-trans retinoic acid (atRA), is required for embryonic development. atRA binds to the nuclear retinoic acid receptors and regulates the transcription of specific target genes. In order to identify atRA-induced g...
Metal-responsive transcription factor (MTF-1) and heavy metal stress response in Drosophila and mammalian cells: a functional comparison [0.03%]
金属应答型转录因子(MTF-1)和重金属胁迫反应在果蝇和哺乳动物细胞中的功能比较研究
Kuppusamy Balamurugan,Dieter Egli,Anand Selvaraj et al.
Kuppusamy Balamurugan et al.
The zinc finger transcription factor MTF-1 (metal-responsive transcription factor-1) is conserved from insects to vertebrates. Its major role in both organisms is to control the transcription of genes involved in the homeostasis and detoxif...
Comparative Study
Biological chemistry. 2004 Jul;385(7):597-603. DOI:10.1515/BC.2004.074 2004
Matthias Bauer,Anne Hamm,Michael J Pankratz
Matthias Bauer
The new scientific field of nutrigenomics utilizes genomic tools, like microarrays, to analyze metabolic adaptations induced by variations in nutritional status. Here we describe how transcriptional regulation patterns caused by nutritional...
Angelo Azzi,René Gysin,Petra Kempná et al.
Angelo Azzi et al.
Several genes are regulated by tocopherols which can be categorized, based on their function, into five groups: genes that are involved in the uptake and degradation of tocopherols (Group 1) include alpha-tocopherol transfer protein (alpha-...
Nutrient-gene interactions: a single nutrient and hundreds of target genes [0.03%]
营养-基因互作：一种营养物质与数百个靶基因之间的关系
Hannelore Daniel,Heike tom Dieck
Hannelore Daniel
Based on the effects of a selective experimental zinc deficiency in a rodent model we explore the use of transcriptome profiling for assessing nutrient-gene interactions in the liver at the molecular and cellular levels. Zinc deficiency cau...
55th Mosbach Colloquium: how nutrients influence gene activity [0.03%]
第55届Mosbach colloquium会议：营养物质如何影响基因活性
Regina Brigelius-Flohé,Josef Köhrle
Regina Brigelius-Flohé