Recombinant expression, purification and cross-reactivity of chenopod profilin: rChe a 2 as a good marker for profilin sensitization [0.03%]
Chen a 2杂交反应性及纯化：作为检测 Chen o 2过敏标志物的可能性研究
Rodrigo Barderas,Mayte Villalba,Rosalía Rodríguez
Rodrigo Barderas
Chenopod pollen is one of the major sources of allergens in some locations in the US, southern Europe and desert countries, and pollen profilin (Che a 2) is a major allergen. Recombinant Che a 2 (rChe a 2) has been produced in Escherichia c...
Fluid shear stress induces endothelial KLF2 gene expression through a defined promoter region [0.03%]
流体剪切应力通过确定的启动子区域诱导内皮细胞KLF2基因表达
Justin P Huddleson,Seetha Srinivasan,Nisar Ahmad et al.
Justin P Huddleson et al.
Fluid shear stress is crucial for maintenance of a properly functioning endothelium. In this study we demonstrate that the KLF2 transcription factor is greatly induced by pulsatile shear stress in murine microvascular endothelial cells. The...
Functional GATA- and initiator-like-elements exhibit a similar arrangement in the promoters of Caenorhabditis elegans polyamine synthesis enzymes [0.03%]
功能性GATA和initiator元件在秀丽隐杆线虫聚胺合成酶启动子中的相似排列
Kai Lüersen,Marie-Luise Eschbach,Eva Liebau et al.
Kai Lüersen et al.
Polyamines are essential cell constituents involved in growth processes. In Caenorhabditis elegans the polyamine synthetic pathway consists of three enzymes, ornithine decarboxylase (ODC), S-adenosylmethionine decarboxylase (AdoMetDC) and s...
Molecular recognition in bone morphogenetic protein (BMP)/receptor interaction [0.03%]
骨形态生成蛋白(BMP)/受体相互作用中的分子识别
Walter Sebald,Joachim Nickel,Jin-Li Zhang et al.
Walter Sebald et al.
Bone morphogenetic proteins (BMPs) and other members of the TGF-beta superfamily are secreted signalling proteins determining the development, maintenance and regeneration of tissues and organs. These dimeric proteins bind, via multiple epi...
Functional genomics identifies novel and diverse molecular targets of nutrients in vivo [0.03%]
功能基因研究在整体水平上鉴定营养物质的新而不同的分子作用靶点
Kishorchandra Gohil
Kishorchandra Gohil
Genomic responses to nutrients are important determinants of physiological and pathological functions of living systems. Many of these responses are mediated by changes in mRNA concentrations that are primarily regulated by gene transcripti...
Regulatory role of membrane-bound peptidases in the progression of gynecologic malignancies [0.03%]
妇科恶性肿瘤发病进展中膜结合型肽酶的调控作用
Kazuhiko Ino,Kiyosumi Shibata,Hiroaki Kajiyama et al.
Kazuhiko Ino et al.
Membrane-bound peptidases play a key role in the control of growth, differentiation, and signal transduction of many cellular systems by degrading bioactive peptides. Thus, abnormal changes in their expression pattern and catalytic function...
Molecular genetics of human cervical cancer: role of papillomavirus and the apoptotic cascade [0.03%]
人宫颈癌的分子遗传学：乳头状病毒和凋亡级联反应的作用
Thokozile Ledwaba,Zodwa Dlamini,Sarala Naicker et al.
Thokozile Ledwaba et al.
Cervical cancer is rated the second most common malignant tumour globally, and is aetiologically linked to human papillomavirus (HPV) infection. Here the cellular pathology under consideration of stem/progenitor cell carcinogenesis is revie...
Cathepsin L is involved in cathepsin D processing and regulation of apoptosis in A549 human lung epithelial cells [0.03%]
猫淋巴蛋白酶L参与Hela细胞中(cathepsin)D的加工及对肺上皮细胞(a549)凋亡的调节作用
Aline Wille,Annegret Gerber,Anke Heimburg et al.
Aline Wille et al.
Cathepsins are implicated in a multitude of physiological and pathophysiological processes. The aim of the present study was to investigate the function of cathepsin L (catL) in the proteolytic network of human lung epithelial cells and its...
Exogenously added GPI-anchored tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) displays enhanced and novel biological activities [0.03%]
外源性添加的GPI锚定基质金属蛋白酶抑制剂-1（TIMP-1）表现出增强和新颖的生物学活性
Roghieh Djafarzadeh,Anke Mojaat,Ana Belen Vicente et al.
Roghieh Djafarzadeh et al.
The family of tissue inhibitors of metalloproteinases (TIMPs) exhibits diverse physiological/biological functions including the inhibition of active matrix metalloproteinases, regulation of proMMP activation, cell growth, and the modulation...
Comparative Study
Biological chemistry. 2004 Jul;385(7):655-63. DOI:10.1515/BC.2004.081 2004
SMAD-signaling in chronic obstructive pulmonary disease: transcriptional down-regulation of inhibitory SMAD 6 and 7 by cigarette smoke [0.03%]
慢性阻塞性肺疾病中SMAD信号的调节：烟草烟雾抑制SMAD6和SMAD7的转录作用
Jochen Springer,Frank R Scholz,Christian Peiser et al.
Jochen Springer et al.
Transforming growth factor-beta1 is a potent mediator of fibrosis stimulating the secretion of extracellular matrix proteins and is involved in airway remodeling in chronic obstructive pulmonary disease (COPD). Signals from the TGF superfam...
Comparative Study
Biological chemistry. 2004 Jul;385(7):649-53. DOI:10.1515/BC.2004.080 2004