Genetic characterization of staphopain genes in Staphylococcus aureus [0.03%]
表皮葡萄球菌中staphopain基因的遗传特征分析
Ewa Golonka,Renata Filipek,Artur Sabat et al.
Ewa Golonka et al.
Staphylococcus aureus , a leading cause of bacterial infections in humans, is endowed with a wealth of virulence factors that contribute to the disease process. Several extracellular proteolytic enzymes, including cysteine proteinases refer...
Coordinate expression of the Porphyromonas gingivalis lysine-specific gingipain proteinase, Kgp, arginine-specific gingipain proteinase, RgpA, and the heme/hemoglobin receptor, HmuR [0.03%]
牙龈卟啉单胞菌赖氨酸特异性牙龈蛋白酶(Kgp)、精氨酸特异性牙龈蛋白酶(RgpA)和血红素/血红蛋白受体(HmuR)的协同表达
Xinyan Liu,Aneta Sroka,Jan Potempa et al.
Xinyan Liu et al.
Heme utilization in Porphyromonas gingivalis requires the participation of an outer membrane hemin/hemoglobin receptor, HmuR, the lysine-specific gingipain proteinase (Kgp) and arginine-specific gingipain proteinase (Rgp). In this study, th...
Roles of Arg- and Lys-gingipains in coaggregation of Porphyromonas gingivalis: identification of its responsible molecules in translation products of rgpA, kgp, and hagA genes [0.03%]
精氨酸和赖氨金属蛋白酶在牙龈卟啉单胞菌共聚现象中的作用：rgpA，kgp及hagA基因翻译产物中负责共聚分子的鉴定
Naoko Abe,Atsuyo Baba,Ryosuke Takii et al.
Naoko Abe et al.
Arg- (Rgp) and Lys-gingipains (Kgp) are two individual cysteine proteinases produced by Porphyromonas gingivalis , an oral anaerobic bacterium, and are implicated as major virulence factors in a wide range of pathologies of adult periodonti...
Design of inhibitors against HIV, HTLV-I, and Plasmodium falciparum aspartic proteases [0.03%]
设计针对HIV、HTLV-I和Plasmodium falciparum的天冬氨酸蛋白酶抑制剂
Hamdy M Abdel-Rahman,Tooru Kimura,Koushi Hidaka et al.
Hamdy M Abdel-Rahman et al.
Aspartic proteases have emerged as targets for substrate-based inhibitor design due to their vital roles in the life cycles of the organisms that cause AIDS, malaria, leukemia, and other infectious diseases. Based on the concept of mimickin...
Secretory leukoprotease inhibitor and pulmonary surfactant serve as principal defenses against influenza A virus infection in the airway and chemical agents up-regulating their levels may have therapeutic potential [0.03%]
分泌型白细胞蛋白酶抑制剂和肺表面活性物质是呼吸道防御流感病毒感染的主要屏障，上调其水平的化学制剂可能具有潜在的治疗价值
Hiroshi Kido,Yuushi Okumura,Hiroshi Yamada et al.
Hiroshi Kido et al.
Influenza A virus (IAV) is one of the most common infectious pathogens in humans. Entry of this virus into cells is primarily determined by host cellular trypsin-type processing proteases, which proteolytically activate viral membrane fusio...
Christopher Jedeszko,Bonnie F Sloane
Christopher Jedeszko
Proteases play causal roles in the malignant progression of human tumors. This review centers on the roles in this process of cysteine cathepsins, i.e., peptidases belonging to the papain family (C1) of the CA clan of cysteine proteases. Cy...
Koki Matsumoto
Koki Matsumoto
Pseudomonas aeruginosa and Serratia marcescens can cause refractory keratitis resulting in corneal perforation and blindness. These bacteria produce various kinds of proteases. In addition to pseudomonal elastase (LasB) and alkaline proteas...
Molecular mechanism for activation and regulation of matrix metalloproteinases during bacterial infections and respiratory inflammation [0.03%]
细菌感染和呼吸系统炎症过程中基质金属蛋白酶的激活与调控机制研究
Tatsuya Okamoto,Teruo Akuta,Fumio Tamura et al.
Tatsuya Okamoto et al.
Matrix metalloproteinases (MMPs) are critical mediators of tissue remodeling. Inappropriate regulation of MMPs causes many pathological events, including microbial invasion and inflammatory tissue damage. Some of the bacterial exoproteinase...
Activation of the kallikrein-kinin system and release of new kinins through alternative cleavage of kininogens by microbial and human cell proteinases [0.03%]
微生物和人类细胞蛋白酶通过肾素-激肽系统的激活以及新的激肽的释放进行替代切割基质白化松质骨
Takahisa Imamura,Jan Potempa,James Travis
Takahisa Imamura
Kinins are released from kininogens through the activation of the Hageman factor-prekallikrein system or by tissue kallikrein. These peptides exert various biological activities, such as vascular permeability increase, smooth muscle contrac...
A monomeric mutant of restriction endonuclease EcoRI nicks DNA without sequence specificity [0.03%]
无序列特异性的EcoRI限制性内切核酸酶单体酶突变体的切害染色体DNA性质
Petra Fritsche,Jürgen Alves
Petra Fritsche
We have mutated the monomer-monomer interface of the restriction endonuclease EcoRI in order to destabilize the homodimer and to stabilize heterodimers. Mutations of Leu158 to charged amino acid residues result in strong destabilization of ...
Comparative Study
Biological chemistry. 2004 Oct;385(10):975-85. DOI:10.1515/BC.2004.127 2004