Molecular structure and transcriptional regulation by nuclear factor-kappaB of the mouse kinin B1 receptor gene [0.03%]
核因子κB对小鼠缓激肽B1受体基因转录调控及该基因的分子结构研究
Vanessa F Merino,José A Silva Jr,Ronaldo C Araújo et al.
Vanessa F Merino et al.
Kinins are important mediators in cardiovascular homeostasis, inflammation, and nociception. Two kinin receptors have been described, B 1 and B 2 . The B 1 receptor is normally absent in healthy tissues, but is highly induced under patholog...
A role for constitutive androstane receptor in the regulation of human intestinal MDR1 expression [0.03%]
核受体CAR调节人肠粘膜P-糖蛋白表达的作用研究
Oliver Burk,Katja A Arnold,Anke Geick et al.
Oliver Burk et al.
MDR1/P-glycoprotein is an efflux transporter determining the absorption and presystemic elimination of many xenobiotics in the gut. Thus, interindividual differences in MDR1 expression may affect the efficacy of drug treatment. The expressi...
Blocking effect of a biotinylated protease inhibitor on the egress of Plasmodium falciparum merozoites from infected red blood cells [0.03%]
一种生物素标记的蛋白酶抑制剂对恶性疟原虫子孢子出红细胞进程的阻断作用
Christoph Gelhaus,Radim Vicik,Tanja Schirmeister et al.
Christoph Gelhaus et al.
The malaria parasite Plasmodium falciparum invades human red blood cells. Before infecting new erythrocytes, the merozoites have to exit their host cell to get into the blood plasma. Knowledge about the mechanism of egress is scarce, but it...
Susceptibility of the interchain peptide of a bromelain inhibitor precursor to the target proteases bromelain, chymotrypsin, and trypsin [0.03%]
菠萝蛋白酶抑制剂前体的链间肽易被菠萝蛋白酶、胃蛋白酶和胰凝乳蛋白酶识别切除
Yoriko Sawano,Ken-ichi Hatano,Masaru Tanokura
Yoriko Sawano
Bromein, a cysteine proteinase inhibitor from pineapple stem, is a unique double-chain inhibitor. The 27.5-kDa precursor protein is processed by the removal of three interchain, two interdomain, and two terminal-flanking peptides, thus resu...
The anti-inflammatory compound curcumin inhibits Neisseria gonorrhoeae-induced NF-kappaB signaling, release of pro-inflammatory cytokines/chemokines and attenuates adhesion in late infection [0.03%]
抗炎化合物姜黄素可抑制淋球菌诱导的NF-κB信号活化、促炎症细胞因子和趋化因子释放以及感染后期的粘附作用
Silja Wessler,Petra Muenzner,Thomas F Meyer et al.
Silja Wessler et al.
Neisseria gonorrhoeae (Ngo) is a Gram-negative pathogenic bacterium responsible for an array of diseases ranging from urethritis to disseminated gonococcal infections. Early events in the establishment of infection involve interactions betw...
Polyadenylate polymerase modulations in human epithelioid cervix and breast cancer cell lines, treated with etoposide or cordycepin, follow cell cycle rather than apoptosis induction [0.03%]
依托泊苷和虫草素处理人宫颈肉瘤和乳腺癌细胞系中多腺苷酸聚合酶的调节遵循细胞周期而不是凋亡诱导
Hellinida Thomadaki,Chris M Tsiapalis,Andreas Scorilas
Hellinida Thomadaki
Cancer results from an imbalance between cell cycle progression and apoptosis. Therefore, most anticancer drugs exert their antiproliferative and cytotoxic activity via cell cycle arrest and induction of apoptosis, a controlled form of cell...
Ultraspiracle promotes the nuclear localization of ecdysteroid receptor in mammalian cells [0.03%]
Ultraspiracle促进ecdysteroid受体在哺乳动物细胞中的核定位
Claudia Nieva,Tomasz Gwóźdź,Joanna Dutko-Gwóźdź et al.
Claudia Nieva et al.
The heterodimer consisting of ecdysteroid receptor (EcR) and ultraspiracle (USP), both of which are members of the nuclear receptor superfamily, is considered to be the functional ecdysteroid receptor. Here we analyzed the subcellular distr...
Adrenodoxin (Adx) and CYP11A1 (P450scc) induce apoptosis by the generation of reactive oxygen species in mitochondria [0.03%]
肾上腺皮质氧化还原调节蛋白和CYP11A1通过在线粒体中生成活性氧诱导细胞凋亡
Evi Derouet-Hümbert,Klaus Roemer,Matthias Bureik
Evi Derouet-Hümbert
Mitochondrial cytochrome P450 systems are an indispensable component of mammalian steroid biosynthesis; they catalyze regio- and stereo-specific steroid hydroxylations and consist of three protein entities: adrenodoxin reductase (AdR), adre...
The composition, structural properties and binding of very-low-density and low-density lipoproteins to the LDL receptor in normo- and hypertriglyceridemia: relation to the apolipoprotein E phenotype [0.03%]
正常和高甘油三脂血症中的极低密度脂蛋白和低密度脂蛋白的组分，结构特性以及与LDL受体结合：与载脂蛋白E表型的关系
Alexander D Dergunov,Alexey V Novoselov,Sophie Visvikis et al.
Alexander D Dergunov et al.
The composition, apolipoprotein structure and lipoprotein binding to the LDL receptor were studied for very-low-density (VLDL) and low-density lipoprotein (LDL) particles isolated from subjects with apoE phenotype E3/3 (E3), E2/2 or E2/3 (E...
An extracellular carboxylesterase from the basidiomycete Pleurotus sapidus hydrolyses xanthophyll esters [0.03%]
来自伞菌裂丝牛肝菌的胞外羧酸酯酶可水解旋花素酯类物质
Holger Zorn,Henning Bouws,Meike Takenberg et al.
Holger Zorn et al.
An extracellular enzyme capable of efficient hydrolysis of xanthophyll esters was purified from culture supernatants of the basidiomycete Pleurotus sapidus. Under native conditions, the enzyme exhibited a molecular mass of 430 kDa, and SDS-...