Functional genetic mouse models: promising tools for investigation of the proteolytic internet [0.03%]
功能基因型小鼠模型：探究蛋白水解“互联网”的有力工具
Achim Krüger
Achim Krüger
Knockout mice are the gold standard to probe for the role of a specific protease within the interacting network of proteases, substrates, and inhibitors. This proteolytic network, or protease web, determines cell signaling and organ homeost...
Overexpression of Pygopus2 protects HeLa cells from vinblastine-induced apoptosis [0.03%]
Pygopus2过表达能保护HeLa细胞免受长春花碱诱导的细胞凋亡的影响
Degejing De,Apeng Chen,Zhiqiang Wu et al.
Degejing De et al.
Pygopus, a very important component of the Wnt signaling transcriptional complex, has multiple functions in both Wnt-dependent and -independent pathways. Human Pygopus2 (Pygo2) is expressed in many cancers and plays an important role in tum...
Regulation of human tissue kallikrein-related peptidase expression by steroid hormones in 32 cell lines [0.03%]
糖皮质激素对人组织激肽释放酶相关肽酶在32种细胞系中表达的调控作用
Julie L V Shaw,Eleftherios P Diamandis
Julie L V Shaw
Human tissue kallikrein-related peptidases(KLK), which are secreted serine proteases, are encoded by 15 genes located on chromosome 19q 13.4. Previous studies have shown that KLK expression is regulated by steroid hormones and many KLKs are...
Erich Gulbins
Erich Gulbins
Glyceryl ether monooxygenase resembles aromatic amino acid hydroxylases in metal ion and tetrahydrobiopterin dependence [0.03%]
甘油醚单加氧酶在金属离子和四氢生物蝶呤依赖性方面类似于芳香族氨基酸羟化酶
Katrin Watschinger,Markus A Keller,Albin Hermetter et al.
Katrin Watschinger et al.
Glyceryl ether monooxygenase is a tetrahydrobiopterin-dependent membrane-bound enzyme which catalyses the cleavage of lipid ethers into glycerol and the corresponding aldehyde. Despite many different characterisation and purification attemp...
Differential functions of the Apoer2 intracellular domain in selenium uptake and cell signaling [0.03%]
Apoer2胞内段在硒吸收和细胞信号转导中的不同作用
Irene Masiulis,Timothy A Quill,Raymond F Burk et al.
Irene Masiulis et al.
Apolipoprotein E receptor 2 (Apoer2) is a multifunctional transport and signaling receptor that regulates the uptake of selenium into the mouse brain and testis through endocytosis of selenoprotein P (Sepp1). Mice deficient in Apoer2 or Sep...
Mannose 6-phosphate receptor-dependent endocytosis of lysosomal enzymes is increased in sulfatide-storing kidney cells [0.03%]
硫酸脂贮积肾细胞中甘露糖-6-磷酸受体介导的溶酶体水解酶内吞作用增强
Diana Klein,Afshin Yaghootfam,Ullrich Matzner et al.
Diana Klein et al.
Metachromatic leukodystrophy is a lysosomal disorder caused by the deficiency of arylsulfatase A (ASA). This leads to the storage of the sphingolipid 3-O-sulfogalactosylceramide (sulfatide) in various cell types, such as renal tubular cells...
Applicability of superfolder YFP bimolecular fluorescence complementation in vitro [0.03%]
超分子体外荧光互补技术的适用性研究-YFP超折叠蛋白的应用
Corinna Ottmann,Michael Weyand,Alexander Wolf et al.
Corinna Ottmann et al.
Bimolecular fluorescence complementation (BiFC) using yellow fluorescent protein (YFP) is a widely employed method to study protein-protein interactions in cells. As yet, this technique has not been used in vitro. To evaluate a possible app...
Heavy metals induce phosphorylation of the Bcl-2 protein by Jun N-terminal kinase [0.03%]
重金属通过Jun氨基末端激酶诱导Bcl-2磷酸化
Eva Ondrousková,Jana Slovácková,Vendula Pelková et al.
Eva Ondrousková et al.
The Bcl-2 protein is one of the key components of biochemical pathways controlling programmed cell death. The function of this protein can be regulated by posttranslational modifications. Phosphorylation of Bcl-2 has been considered to be s...