Cholesterol is the major component of native lipoproteins activating the p38 mitogen-activated protein kinases [0.03%]
胆固醇是激活p38丝裂原活化的蛋白激酶的脂蛋白成分
Iveta Dobreva,Olaf Zschörnig,Gérard Waeber et al.
Iveta Dobreva et al.
Elevated low-density lipoprotein (LDL) levels induce activation of the p38 mitogen-activated protein kinase (MAPK), a stress-activated protein kinase potentially participating in the development of atherosclerosis. The nature of the lipopro...
Determination of the specificity of monoclonal antibodies against Schistosoma mansoni CAA glycoprotein antigen using neoglycoconjugate variants [0.03%]
用新糖蛋白抗原决定点多瘤尾吸虫CAA糖蛋白单克隆抗体的特异性
Adriana Carvalho de Souza,Alexandra van Remoortere,Cornelis H Hokke et al.
Adriana Carvalho de Souza et al.
The immunogenic O-glycan of circulating anodic antigen (CAA) is a high-molecular-mass polysaccharide with the unique -->6)-[beta-D-GlcpA-(1-->3)]-beta-D-GalpNAc-(1--> repeating unit. To obtain information at the molecular level about the sp...
Lysine 3 acetylation regulates the phosphorylation of yeast 6-phosphofructo-2-kinase under hypo-osmotic stress [0.03%]
低渗胁迫下赖氨酸3乙酰化调控酵母6-磷酸果糖-2-激酶的磷酸化修饰
Hassan Dihazi,Renate Kessler,Gerhard A Müller et al.
Hassan Dihazi et al.
N-terminal acetylation in the yeast Saccharomyces cerevisiae is catalysed by any of three N-terminal acetyltransferases (NAT), NatA, NatB, and NatC, which contain the catalytic subunits Ard1p, Nat3p and Mak3p, respectively. Yeast 6-phosphof...
Role of the N-terminal region and of beta-sheet residue Thr29 on the activity of the omega2 global regulator from the broad-host range Streptococcus pyogenes plasmid pSM19035 [0.03%]
N端区域和β折叠链Thr29残基在广宿主范围链球菌pSM19035质粒全局调节因子omega2中的作用研究
Karin Welfle,Florencia Pratto,Rolf Misselwitz et al.
Karin Welfle et al.
The dimeric regulatory protein wild-type omega (wt omega2) binds to arrays of 7-bp sequences (heptads) present in the operator DNA region of copy control and partition functions of plasmid pSM19035. Each omega2 protein probably binds with a...
Regulation of asparagine synthetase gene transcription by the basic region leucine zipper transcription factors ATF5 and CHOP [0.03%]
激活蛋白转录因子5和碳氢氧磷酸的碱性区域亮氨酸拉链型转录因子通过调控天冬酰胺合成酶基因的转录以调节其表达水平
Jude Al Sarraj,Charles Vinson,Gerald Thiel
Jude Al Sarraj
Asparagine synthetase catalyses the glutamine- and ATP-dependent conversion of aspartic acid to asparagine. In human hepatoma cells cultured in medium containing amino acids, the mRNA of asparagine synthetase is not detectable by RNase prot...
NF-kappaB contributes to transcription of placenta growth factor and interacts with metal responsive transcription factor-1 in hypoxic human cells [0.03%]
NF-κB通过与金属反应性转录因子-1相互作用促进缺氧人细胞中胎盘生长因子的转录
Mirjam Cramer,Ivana Nagy,Brian J Murphy et al.
Mirjam Cramer et al.
Placenta growth factor (PlGF) is a member of the vascular endothelial growth factor family of cytokines that control vascular and lymphatic endothelium development. It has been implicated in promoting angiogenesis in pathological conditions...
Developing an effective RNA interference strategy against a plus-strand RNA virus: silencing of coxsackievirus B3 and its cognate coxsackievirus-adenovirus receptor [0.03%]
一种针对正链RNA病毒的有效RNA干扰策略的研制：对柯萨奇B3病毒及其同源柯萨奇病毒腺病毒共受体进行干扰
Denise Werk,Steffen Schubert,Vanessa Lindig et al.
Denise Werk et al.
Coxsackievirus B3 (CVB-3) is a plus-strand RNA virus that is believed to be the most common causal agent of viral myocarditis. Since no specific treatment for CVB-3 infections is available to date, we and others have recently started to dev...
GPCR-induced migration of breast carcinoma cells depends on both EGFR signal transactivation and EGFR-independent pathways [0.03%]
G蛋白偶联受体诱导的乳腺癌细胞迁移依赖表皮生长因子受体信号转导和不受表皮生长因子受体调节的途径
Stefan Hart,Oliver M Fischer,Norbert Prenzel et al.
Stefan Hart et al.
The epidermal growth factor receptor (EGFR) plays a key role in the regulation of important cellular processes under normal and pathophysiological conditions such as cancer. In human mammary carcinomas the EGFR is involved in regulating cel...
Symmetry at the active site of the ribosome: structural and functional implications [0.03%]
核糖体活性位点的对称性：结构和功能意义
Ilana Agmon,Anat Bashan,Raz Zarivach et al.
Ilana Agmon et al.
The sizable symmetrical region, comprising 180 ribosomal RNA nucleotides, which has been identified in and around the peptidyl transferase center (PTC) in crystal structures of eubacterial and archaeal large ribosomal subunits, indicates it...
Improving the levels of essential amino acids and sulfur metabolites in plants [0.03%]
提高植物必需氨基酸和硫代谢产物的含量
Gad Galili,Rachel Amir,Rainer Hoefgen et al.
Gad Galili et al.
Plants represent the major source of food for humans, either directly or indirectly through their use as livestock feeds. Plant foods are not nutritionally balanced because they contain low proportions of a number of essential metabolites, ...