Nucleotide binding and filament assembly of recombinant yeast septin complexes [0.03%]
重组酵母Septin复合物的核苷酸结合及丝状装配
Marian Farkasovsky,Peter Herter,Beate Voss et al.
Marian Farkasovsky et al.
Septins are filament-forming GTPases involved in cytokinesis and cortical organization. In the yeast Saccharomyces cerevisiae, the septins encoded by CDC3, CDC10, CDC11, and CDC12 form a high-molecular-weight complex, localized at the cytop...
Characterization of oligomeric species in the fibrillization pathway of the yeast prion Ure2p [0.03%]
酿酒酵母菌丝素Ure2p纤维化途径中寡聚物种的表征
Silvia Catharino,Johannes Buchner,Stefan Walter
Silvia Catharino
The [URE3] prion of Saccharomyces cerevisiae shares many features with mammalian prions and poly-glutamine related disorders and has become a model for studying amyloid diseases. The development of the [URE3] phenotype is thought to be caus...
Rearrangements in a hydrophobic core region mediate cAMP action in the regulatory subunit of PKA [0.03%]
环腺苷酸介导蛋白激酶A调控亚基疏水核区的重排
Claudia Hahnefeld,Daniela Moll,Maik Goette et al.
Claudia Hahnefeld et al.
cAMP-dependent protein kinase (PKA) forms an inactive heterotetramer of two regulatory (R; with two cAMP-binding domains A and B each) and two catalytic (C) subunits. Upon the binding of four cAMP molecules to the R dimer, the monomeric C s...
Psc3 cohesin of Schizosaccharomyces pombe: cell cycle analysis and identification of three distinct isoforms [0.03%]
粟酒裂殖酵母Psc3黏连素：细胞周期分析及三种不同亚型的鉴定
Eduard Ilyushik,David W Pryce,Dawid Walerych et al.
Eduard Ilyushik et al.
Cohesins are a group of proteins that function to mediate correct chromosome segregation, DNA repair and meiotic recombination. This report presents the amino acid sequence for the Schizosaccharomyces pombe cohesin Psc3 based on the transla...
Peter Friedrich,Zoltán Bozóky
Peter Friedrich
Calpains, the cytoplasmic Ca2+-activated regulatory proteases, have no simple and clearly definable cleavage site specificity, which is in sharp contrast to digestive (e.g., pancreatic) proteases. For calpains, an approximate 10-aa segment ...
Effects of elastase and cathepsin G on the levels of membrane and soluble TNFalpha [0.03%]
弹性蛋白酶和 катhepsin G对细胞膜及可溶性TNFα水平的影响
Renata Mezyk-Kopeć,Małgorzata Bzowska,Monika Bzowska et al.
Renata Mezyk-Kopeć et al.
Neutrophil elastase (NE) and cathepsin G (CG), the proteolytic enzymes localized in azurophil granules of neutrophils (PMN), are involved in PMN responses to various stimuli. When released at sites of inflammation, they participate in the d...
The precursor of secreted aspartic proteinase Sapp1p from Candida parapsilosis can be activated both autocatalytically and by a membrane-bound processing proteinase [0.03%]
白假丝酵母分泌天冬氨酸蛋白酶Sapp1的前体既可以自催化解折叠又可以由膜结合加工酶活化释放
Jirí Dostál,Helena Dlouhá,Petr Malon et al.
Jirí Dostál et al.
Opportunistic pathogens of the genus Candida produce secreted aspartic proteinases (Saps) that play an important role in virulence. Saps are synthesized as zymogens, but cell-free culture supernatants of Candida spp. contain only mature Sap...
Comparative Study
Biological chemistry. 2005 Aug;386(8):791-9. DOI:10.1515/BC.2005.093 2005
Frank Döring,Roland Schmitt,Wanja M Bernhardt et al.
Frank Döring et al.
The kidney is a target organ for thyroid hormone action and a variety of renal transport processes are altered in response to impaired thyroid functions. To investigate the effect of thyroid hormone on the expression of the renal proximal t...
Comparative Study
Biological chemistry. 2005 Aug;386(8):785-90. DOI:10.1515/BC.2005.092 2005
Differential accumulation of plastid preprotein translocon components during spruce (Picea abies L. Karst.) needle development [0.03%]
云杉针叶发育过程中质体预蛋白转运复合体组分的差异积累
Hrvoje Fulgosi,Hrvoje Lepedus,Vera Cesar et al.
Hrvoje Fulgosi et al.
We demonstrate that basic components of the plastid protein-import apparatus originally found in pea, Toc34, Toc159, and Tic110, are also conserved in evolutionarily younger gymnosperms. We show that multiple isoforms of the preprotein rece...
Intact growth factors are conserved in the extracellular matrix of ancient human bone and teeth: a storehouse for the study of human evolution in health and disease [0.03%]
古人类骨骼和牙齿的细胞外基质中完整生长因子的保存：健康与疾病下的人类进化研究宝库
Tyede H Schmidt-Schultz,Michael Schultz
Tyede H Schmidt-Schultz
For the first time we have extracted, solubilized and identified growth factors, such as insulin growth factor II (IGF-II), bone morphogenetic protein-2 (BMP-2), and transforming growth factor-beta (TGF-beta), from archaeological compact hu...