Structural and functional comparison of HemN to other radical SAM enzymes [0.03%]
HemN的结构和功能与其他RADICAL SAM酶比较
Gunhild Layer,Eric Kervio,Gaby Morlock et al.
Gunhild Layer et al.
Radical SAM enzymes have only recently been recognized as an ancient family sharing an unusual radical-based reaction mechanism. This late appreciation is due to the extreme oxygen sensitivity of most radical SAM enzymes, making their chara...
Heterodisulfide reductase from methanogenic archaea: a new catalytic role for an iron-sulfur cluster [0.03%]
甲烷古菌中的异硫化物还原酶：铁-硫簇的新催化作用
Reiner Hedderich,Nils Hamann,Marina Bennati
Reiner Hedderich
Heterodisulfide reductase (HDR) from methanogenic archaea is an iron-sulfur protein that catalyzes reversible reduction of the heterodisulfide (CoM-S-S-CoB) of the methanogenic thiol-coenzymes, coenzyme M (CoM-SH) and coenzyme B (CoB-SH). V...
Wolfgang Buckel,Berta M Martins,Albrecht Messerschmidt et al.
Wolfgang Buckel et al.
Most dehydratases catalyse the elimination of water from beta-hydroxy ketones, beta-hydroxy carboxylic acids or beta-hydroxyacyl-CoA. The electron-withdrawing carbonyl functionalities acidify the alpha-hydrogens to enable their removal by b...
hDLG/SAP97, a member of the MAGUK protein family, is a novel caspase target during cell-cell detachment in apoptosis [0.03%]
含多个跨膜结构域的蛋白HDLG/SAP97是凋亡过程中细胞间脱离时新的半胱天冬酶作用底物
Uros Gregorc,Saska Ivanova,Miranda Thomas et al.
Uros Gregorc et al.
Cell-cell detachment is one of the hallmarks of apoptosis. To date, several transmembrane and plaque proteins from tight and adherent junctions have been characterised as caspase targets during apoptosis. Human discs large protein (hDLG)/SA...
A possible alternative mechanism of kinin generation in vivo by cathepsin L [0.03%]
活体中通过猫淋巴蛋白酶生成激肽的可能替代机制
Luciano Puzer,Juliana Vercesi,Marcio F M Alves et al.
Luciano Puzer et al.
We investigated the ability of cathepsin L to induce a hypotensive effect after intravenous injection in rats and correlated this decrease in blood pressure with kinin generation. Simultaneously with blood pressure decrease, we detected pla...
Kinetics of autocatalytic zymogen activation measured by a coupled reaction: pepsinogen autoactivation [0.03%]
通过偶联反应测定自催化zymogen激活的动力学：胃蛋白酶原自身活化
Matilde-Esther Fuentes,Ramón Varón,Manuela García-Moreno et al.
Matilde-Esther Fuentes et al.
A kinetic study was performed of a model for an autocatalytic zymogen activation process involving both intra- and intermolecular routes, to which a chromogenic reaction in which the active enzyme acts upon one of its substrates was coupled...
Antidiabetic potential of two novel fatty acid derivatised, N-terminally modified analogues of glucose-dependent insulinotropic polypeptide (GIP): N-AcGIP(LysPAL16) and N-AcGIP(LysPAL37) [0.03%]
两种新型脂肪酸衍生的，N末端修饰的葡萄糖依赖性胰岛素多肽（GIP）类似物(N-AcGIP(LysPAL16)和N-AcGIP(LysPAL37))的抗糖尿病潜力研究
Nigel Irwin,Victor A Gault,Brian D Green et al.
Nigel Irwin et al.
Fatty acid derivatisation was used to develop two novel, long-acting, N-terminally modified, glucose-dependent insulinotropic polypeptide (GIP) analogues, N-AcGIP(LysPAL16) and N-AcGIP(LysPAL37). In contrast to GIP, which was rapidly degrad...
Iskender Teber,Fumiko Nagano,Joachim Kremerskothen et al.
Iskender Teber et al.
The Rab6 GTPase regulates a retrograde transport route connecting endosomes and the endoplasmic reticulum (ER) via the Golgi apparatus. Recently it was shown that active (GTP-loaded) Rab6A regulates intracellular processing of the amyloid p...
Matthias Bureik,Alexander Mion,Christopher J Kenyon et al.
Matthias Bureik et al.
Staurosporine (STS) is a very potent broad-range kinase inhibitor, and its antiproliferative properties made it a lead compound for protein kinase C (PKC) inhibitors with therapeutic potential. Because STS also causes hypotension, we invest...
Identification and partial characterization of two eukaryotic UDP-galactopyranose mutases [0.03%]
两个真核UDP-半乳糖吡喃糖苷异构酶的鉴定和部分定性分析
Hans Bakker,Barbara Kleczka,Rita Gerardy-Schahn et al.
Hans Bakker et al.
Galactofuranose metabolism is valued as an important target for the development of new antituberculosis drugs. UDP-galactopyranose mutase, a central enzyme in galactofuranose biosynthesis, is essential for the growth and viability of mycoba...