Interplay of human tissue kallikrein 4 (hK4) with the plasminogen activation system: hK4 regulates the structure and functions of the urokinase-type plasminogen activator receptor (uPAR) [0.03%]
人组织激肽释放酶4（hK4）与纤溶酶原激活系统之间的相互作用：hK4调节urokinase型纤溶酶原激活物受体（uPAR）的结构和功能
Nathalie Beaufort,Mekdes Debela,Sabine Creutzburg et al.
Nathalie Beaufort et al.
The plasminogen activation system is involved in cancer progression and metastasis. Among other proteolytic factors, it includes the serine protease urokinase-type plasminogen activator (uPA) and its three-domain (D1D2D3) receptor uPAR (CD8...
Molecular identification and pharmacological profile of the bovine kinin B1 receptor [0.03%]
牛激肽B1受体的分子鉴定及其药理特征
Guillaume Morissette,François Marceau
Guillaume Morissette
To support the study of kinin pharmacology in bovine models of cultured endothelial cells (ECs), the Bovine Genome Project was searched for a B1 receptor (B1R) gene ortholog (BDKRB1). A contig complementary to an intronless coding nucleotid...
Comparative Study
Biological chemistry. 2006 Feb;387(2):211-5. DOI:10.1515/BC.2006.028 2006
The role of bradykinin B1 receptor on cardiac remodeling in stroke-prone spontaneously hypertensive rats (SHR-SP) [0.03%]
缓激肽B1受体在卒中倾向性遗传性高血压大鼠心脏重塑中的作用研究
Norihito Moniwa,Jun Agata,Makoto Hagiwara et al.
Norihito Moniwa et al.
An angiotensin-converting enzyme inhibitor (ACE-I) reduces cardiac remodeling and a bradykinin B2 receptor (B2R) antagonist partially abolishes this ACE-I effect. However, bradykinin has two different types of receptor, the B1 receptor (B1R...
Generation and characterization of a humanized bradykinin B1 receptor mouse [0.03%]
人源化缓激肽B1受体小鼠的构建及鉴定
J Fred Hess,Richard Z Chen,Patricia Hey et al.
J Fred Hess et al.
Antagonists of the B1 bradykinin receptor (B1R), encoded by the BDKRB1 gene, offer the promise of novel therapeutic agents for inflammatory and neuropathic pain. However, the in vivo characterization of the pharmacodynamics of B1R antagonis...
Dual antagonists of the bradykinin B1 and B2 receptors based on a postulated common pharmacophore from existing non-peptide antagonists [0.03%]
基于现有的非肽类拮抗剂假定的共同药效团的双功能激肽B1和B2受体拮抗剂
Guillaume Morissette,Johanne Bouthillier,François Marceau
Guillaume Morissette
We have recently drawn attention to the fact that most non-peptide antagonists of the kinin B1 receptor reported so far are structurally related, possessing the core motif phenyl-SO2-NR-(spacer(2-4))-CO-NRR. This is found in compound A (N-[...
Three-dimensional structure of an AMPA receptor without associated stargazin/TARP proteins [0.03%]
不结合stargazin/TARP蛋白的AMPA受体的三维结构
Terunaga Nakagawa,Yifan Cheng,Morgan Sheng et al.
Terunaga Nakagawa et al.
Most excitatory synaptic transmissions in the central nervous system are mediated by the neurotransmitter glutamate. Binding of glutamate released from the presynaptic membrane causes glutamate receptors in the postsynaptic membrane to open...
Platelets promote coagulation factor XII-mediated proteolytic cascade systems in plasma [0.03%]
血小板促进凝血因子XII介导的血液中蛋白水解级联系统
Julia Johne,Constanze Blume,Peter M Benz et al.
Julia Johne et al.
Blood coagulation factor XII (FXII, Hageman factor) is a plasma serine protease which is autoactivated following contact with negatively charged surfaces in a reaction involving plasma kallikrein and high-molecular-weight kininogen (contact...
Anti-inflammatory effects of kinins via microglia in the central nervous system [0.03%]
炎症介质缓激肽通过中枢神经系统的小胶质细胞产生抗炎效应
Mami Noda,Helmut Kettenmann,Keiji Wada
Mami Noda
Kinins are important biologically active peptides that are up-regulated after lesions in both the peripheral and central (CNS) nervous systems. Microglia are immune cells in the CNS and play an important role in the defense of the neuronal ...
Kinin- and angiotensin-converting enzyme (ACE) inhibitor-mediated nitric oxide production in endothelial cells [0.03%]
激肽和血管紧张素转化酶(ACE)抑制剂介导的内皮细胞一氧化氮生成
Randal A Skidgel,Sinisa Stanisavljevic,Ervin G Erdös
Randal A Skidgel
Carboxypeptidase cleavage of the C-terminal Arg of kinins generates specific agonists of the B1 receptor. Activation of B1 receptors produces nitric oxide via eNOS in bovine endothelial cells and iNOS in cytokine-stimulated human endothelia...
Stefano Taddei,Agostino Virdis,Lorenzo Ghiadoni et al.
Stefano Taddei et al.
The endothelium plays a primary role in the local control of vascular function and structure, mainly by the production and release of NO, a potent vasodilator that also inhibits all the mechanisms involved in the pathogenesis of atheroscler...