Exploring the pathogenesis of renal cell carcinoma: pathway and bioinformatics analysis of dysregulated genes and proteins [0.03%]
探索肾细胞癌发病机制：异常基因和蛋白质通路及生物信息学分析
Alexander D Romaschin,Youssef Youssef,Tsz-fung F Chow et al.
Alexander D Romaschin et al.
We recently identified a group of proteins which are dysregulated in renal cell carcinoma (RCC). In this study, we performed bioinformatics and pathway analysis of these proteins. Proteins were mapped to gene ontology biological processes. ...
Fibroblast growth factor 2 (FGF-2) is a novel substrate for arginine methylation by PRMT5 [0.03%]
脯氨酰-tRNA合成酶是一种新型的PRMT5甲基转移酶底物
Alexander-Francisco Bruns,Claudia Grothe,Peter Claus
Alexander-Francisco Bruns
Fibroblast growth factor 2 (FGF-2) is expressed in isoforms of different molecular masses from one mRNA species by alternative start of translation. The higher molecular mass isoforms (FGF-2(21) and (23)) contain an arginine-rich N-terminus...
Selectivity of propeptide-enzyme interaction in cathepsin L-like cysteine proteases [0.03%]
猫爪素L样半胱氨酸蛋白酶的前肽-酶相互作用的选择性
Klaus Schilling,Alexandra Körner,Saskia Sehmisch et al.
Klaus Schilling et al.
Cathepsin L-like endopeptidases of the papain family are synthesized as proenzymes. N-terminal proregions are essential for folding and latency of the enzyme unit. While selectivity has been reported for the inhibitory function of papain-fa...
Aptamers selected against the unglycosylated EGFRvIII ectodomain and delivered intracellularly reduce membrane-bound EGFRvIII and induce apoptosis [0.03%]
针对未糖基化的EGFRvIII胞外区选择并能够被递送进细胞的适配子可以降低膜结合型的EGFRvIII 并诱导凋亡
Yingmiao Liu,Chien-Tsun Kuan,Jing Mi et al.
Yingmiao Liu et al.
Epidermal growth factor receptor variant III (EGFRvIII) is a glycoprotein uniquely expressed in glioblastoma, but not in normal brain tissues. To develop targeted therapies for brain tumors, we selected RNA aptamers against the histidine-ta...
Murine and human cathepsin B exhibit similar properties: possible implications for drug discovery [0.03%]
鼠源和人源Cathepsin B具有相似的性质：药物发现中的应用前景
Dejan Caglic,Gregor Kosec,Lea Bojic et al.
Dejan Caglic et al.
Validation of drug targets and subsequent preclinical studies are usually carried out on animal disease models, with mouse being the most commonly used. However, results from mouse models cannot always be directly related to human disease. ...
Mercury and cadmium trigger expression of the copper importer Ctr1B, which enables Drosophila to thrive on heavy metal-loaded food [0.03%]
汞和镉可诱导铜转运蛋白Ctr1B的表达以使果蝇在重金属环境中茁壮成长
Kuppusamy Balamurugan,Haiqing Hua,Oleg Georgiev et al.
Kuppusamy Balamurugan et al.
Organisms from insects to mammals respond to heavy metal load (copper, zinc, cadmium, and mercury) by activating the metal-responsive transcription factor 1 (MTF-1). MTF-1 binds to short DNA sequence motifs, termed metal response elements, ...
Primary sequence, together with other factors, influence peptide deimination by peptidylarginine deiminase-4 [0.03%]
primary sequence与其它因素共同影响PAD4诱导的肽精氨脱亚胺化
Maria E Stensland,Sylvie Pollmann,Øyvind Molberg et al.
Maria E Stensland et al.
Enzymes of the peptidylarginine deiminase (PAD) family catalyze the posttranslational deimination of polypeptide-bound arginine residues. Here, we report the selection of peptide substrates by PAD-4, an isoform thought to be involved in the...
Interferon-gamma-mediated pathways and in vitro PBMC proliferation in HIV-infected patients [0.03%]
干扰素-γ介导的途径和HIV感染患者的体外PBMC增殖反应关系的研究
Katharina Schroecksnadel,Christiana Winkler,Ernst R Werner et al.
Katharina Schroecksnadel et al.
HIV infection is characterized by progressive immunodeficiency: HIV-infected peripheral blood mononuclear cells (PBMCs) cannot properly react to stimulation with allo-antigens and mitogens. In this study, we examined interferon-gamma (IFN-g...
Isotope tracing enhancement of chemiluminescence assays for nitric oxide research [0.03%]
同位素示踪增强的化学发光法测定 NO 及其在 NO 研究中的应用
Julia Cornelius,Tuan Tran,Nicole Turner et al.
Julia Cornelius et al.
Chemiluminescence assays are used widely for the detection of nitric oxide (NO)-derived species in biological fluids and tissues. Here, we demonstrate that these assays can be interfaced with mass-sensitive detectors for parallel determinat...
Involvement of heparan sulfate proteoglycans in cellular uptake of high molecular weight kininogen [0.03%]
肝素硫酸蛋白聚糖参与高分子量激肽原细胞摄取作用
Katia R B Melo,Augusto Gutierrez,Fabio D Nascimento et al.
Katia R B Melo et al.
In this study, we analyzed the influence of proteoglycans on the interaction between human high molecular weight kininogen (HK) and the cell surface. We found that D5- related peptide inhibits HK-biotin cellular uptake. Confocal microscopy ...