A structural model of 20S immunoproteasomes: effect of LMP2 codon 60 polymorphism on expression, activity, intracellular localisation and insight into the regulatory mechanisms [0.03%]
20S免疫蛋白酶体结构模型：LMP2第60号密码子多态性对表达、活性及亚细胞定位的影响及对其调节机制的见解
Michele Mishto,Aurelia Santoro,Elena Bellavista et al.
Michele Mishto et al.
The immunoproteasome subunit low molecular weight protein 2 (LMP2) codon 60 polymorphism has been associated with autoimmune diseases. It has also been demonstrated to influence susceptibility to TNF-alpha-induced apoptosis in blood cells a...
Chiral distinction between the enantiomers of bicyclic alcohols by UDP-glucuronosyltransferases 2B7 and 2B17 [0.03%]
UDP-葡萄糖醛酸转移酶2B7和2B17对双环醇类化合物对映异构体的手性区别作用研究
Ingo Bichlmaier,Antti Siiskonen,Mika Kurkela et al.
Ingo Bichlmaier et al.
The stereoselective binding and transformation of optically pure bicyclic alcohols by human UDP-glucuronosyltransferases from subfamily 2B were investigated. The enantiomers of 1-indanol, 1-tetralol, and 1-benzosuberol were synthesized by a...
The roles of ATP in the dynamics of the actin filaments of the cytoskeleton [0.03%]
ATP在细胞骨架肌动蛋白丝动态变化中的作用
Erwin W Becker
Erwin W Becker
In contrast to the actin filaments of muscle, which are stabilized by special proteins, actin filaments of the cytoskeleton are highly dynamic. In vitro observations at room temperature have led to the conclusion that the hydrolysis of ATP,...
Evidence for attenuated cellular 8-oxo-7,8-dihydro-2'-deoxyguanosine removal in cancer patients [0.03%]
癌症患者细胞中8-氧代-7,8-二氢-2'-脱氧鸟苷清除作用减弱的证据
Marcus S Cooke,Rafal Rozalski,Rosamund Dove et al.
Marcus S Cooke et al.
Measurement of the products of oxidatively damaged DNA in urine is a frequently used means by which oxidative stress may be assessed non-invasively. We believe that urinary DNA lesions, in addition to being biomarkers of oxidative stress, c...
Comparative Study
Biological chemistry. 2006 Apr;387(4):393-400. DOI:10.1515/BC.2006.053 2006
Cancer-preventive anti-oxidants that attenuate free radical generation by inflammatory cells [0.03%]
抗癌抗氧化剂可减弱炎症细胞产生自由基的功能
Akira Murakami,Hajime Ohigashi
Akira Murakami
Active inflammatory leukocytes are a major endogenous source of reactive oxygen and nitrogen oxide species (RONS). We have recently established novel bioassay systems, in which either phorbol ester-stimulated, differentiated HL-60 human leu...
Concomitant suppression of hyperlipidemia and intestinal polyp formation by increasing lipoprotein lipase activity in Apc-deficient mice [0.03%]
通过增加Apc缺陷型小鼠的脂蛋白脂肪酶活性来同时抑制高血脂和肠道息肉形成
Michihiro Mutoh,Naoko Niho,Keiji Wakabayashi
Michihiro Mutoh
Epidemiologically, a high-fat diet is associated with the risk of colon cancer. In addition, serum levels of triglycerides (TGs) and cholesterol have been demonstrated to be positively associated with colon carcinogenesis. We recently found...
Yusaku Nakabeppu,Kunihiko Sakumi,Katsumi Sakamoto et al.
Yusaku Nakabeppu et al.
Genomes and their precursor nucleotides are highly exposed to reactive oxygen species, which are generated both as byproducts of oxygen respiration or molecular executors in the host defense, and by environmental exposure to ionizing radiat...
Oxidative and nitrative DNA damage in animals and patients with inflammatory diseases in relation to inflammation-related carcinogenesis [0.03%]
炎症相关癌症中动物和患者的氧化和硝化DNA损伤关系研究
Shosuke Kawanishi,Yusuke Hiraku,Somchai Pinlaor et al.
Shosuke Kawanishi et al.
Infection and chronic inflammation are proposed to contribute to carcinogenesis through inflammation-related mechanisms. Infection with hepatitis C virus, Helicobacter pylori and the liver fluke, Opisthorchis viverrini (OV), are important r...
Pelayo Correa
Pelayo Correa
Epidemiologic evidence strongly supports a causal role for Helicobacter pylori in gastric carcinogenesis. The infection was recognized as a Class I human carcinogen by the International Agency for Research on Cancer in 1994. The bacterium d...
Risk factors and mechanisms of hepatocarcinogenesis with special emphasis on alcohol and oxidative stress [0.03%]
以酒精和氧化应激为重点的肝癌发生的风险因素及机制研究
Helmut K Seitz,Felix Stickel
Helmut K Seitz
Hepatocellular cancer is the fifth most frequent cancer in men and the eighth in women worldwide. Established risk factors are chronic hepatitis B and C infection, chronic heavy alcohol consumption, obesity and type 2 diabetes, tobacco use,...