Proteinase-mediated cell signalling: targeting proteinase-activated receptors (PARs) by kallikreins and more [0.03%]
蛋白酶介导的细胞信号转导：激肽原酶及其他酶对蛋白酶活化受体(PARs)的作用
Katerina Oikonomopoulou,Kristina K Hansen,Mahmoud Saifeddine et al.
Katerina Oikonomopoulou et al.
Serine proteinases, like trypsin, can play a hormone-like role by triggering signal transduction pathways in target cells. In many respects these hormone-like actions of proteinases can now be understood in terms of the pharmacodynamics of ...
The tissue kallikrein-kinin system protects against cardiovascular and renal diseases and ischemic stroke independently of blood pressure reduction [0.03%]
组织激肽释放酶-激肽系统通过降压独立机制防治心血管疾病、肾病和缺血性脑卒中
Julie Chao,Grant Bledsoe,Hang Yin et al.
Julie Chao et al.
Tissue kallikrein (hK1) cleaves low-molecular-weight kininogen to produce kinin peptide, which binds to kinin receptors and triggers a wide spectrum of biological effects. Tissue kallikrein levels are reduced in humans and in animal models ...
Cellular distribution of human tissue kallikreins: immunohistochemical localization [0.03%]
人组织激肽释放酶的细胞分布：免疫组化定位
Constantina D Petraki,Panagiotis A Papanastasiou,Vassiliki N Karavana et al.
Constantina D Petraki et al.
We have studied the immunohistochemical expression (IE) of eight non-tissue-specific human kallikreins (hKs) (hK5, 6, 7, 10, 11, 12, 13, and 14) in different normal tissues. The IE was always cytoplasmic, showing a characteristic pattern in...
The kallikrein world: an update on the human tissue kallikreins [0.03%]
凝血酶世界：关于组织激肽释放酶的人类版本的最新研究进展报告
Miltiadis Paliouras,Eleftherios P Diamandis
Miltiadis Paliouras
Human tissue kallikreins (hKs) are attracting increased attention owing to their association with various forms of cancer and other diseases. Human tissue kallikrein genes represent the largest contiguous group of proteases within the human...
A comprehensive nomenclature for serine proteases with homology to tissue kallikreins [0.03%]
一种与组织激肽释放酶同源的丝氨酸蛋白酶命名法
Ake Lundwall,Vimla Band,Michael Blaber et al.
Ake Lundwall et al.
The human kallikrein locus on chromosome 19q13.3-13.4 contains kallikrein 1--the tissue kallikrein--and 14 related serine proteases. Recent investigations into their function and evolution have indicated that the present nomenclature for th...
Simon Caserman,Sasa Kenig,Bonnie F Sloane et al.
Simon Caserman et al.
Transcripts of the lysosomal cysteine proteinase cathepsin L are spliced into five variants (L-A, L-A1, LA-2, LA-3 and L-B), which have similar stabilities but different translation efficiencies, thus potentially yielding diverse amounts of...
Mu-calpain binds to lipid bilayers via the exposed hydrophobic surface of its Ca2+-activated conformation [0.03%]
μ-钙蛋白酶通过其Ca2+激活构象的疏水面与脂质双层结合
Amaury Fernández-Montalván,Irmgard Assfalg-Machleidt,Dietmar Pfeiler et al.
Amaury Fernández-Montalván et al.
Mu- and m-calpain are cysteine proteases requiring micro- and millimolar Ca2+ concentrations for their activation in vitro. Among other mechanisms, interaction of calpains with membrane phospholipids has been proposed to facilitate their ac...
Angiotensin I-converting enzyme inhibitor peptides derived from the endostatin-containing NC1 fragment of human collagen XVIII [0.03%]
源自含端刺素的人体ⅩⅧ型胶原NC1区段的血管紧张素转换酶抑制肽
Shirley L Farias,Regiane A Sabatini,Tatiana C Sampaio et al.
Shirley L Farias et al.
Extracellular matrix and soluble plasma proteins generate peptides that regulate biological activities such as cell growth, differentiation and migration. Bradykinin, a peptide released from kininogen by kallikreins, stimulates vasodilatati...
C-terminal fusion of eGFP to the bradykinin B2 receptor strongly affects down-regulation but not receptor internalization or signaling [0.03%]
eGFP与缓激肽B2受体相融合影响受体下调但是不影响受体胞吞或者信号转导
Irina Kalatskaya,Steffen Schüssler,Cornelia Seidl et al.
Irina Kalatskaya et al.
A functional comparison was made between the wild-type bradykinin B2 receptor (B2wt) and the chimera B2eGFP (enhanced green-fluorescent protein fused to the C-terminus of B2wt), both stably expressed in HEK 293 cells. There was almost no di...