Lei Zhu,Hannu Koistinen,Ping Wu et al.
Lei Zhu et al.
Prostate-specific antigen (PSA) is a widely used marker for prostate cancer. The utility of PSA tests is limited by their inability to differentiate prostate cancer from non-malignant conditions such as benign prostatic hyperplasia and pros...
Kallikrein-related peptidase 14 may be a major contributor to trypsin-like proteolytic activity in human stratum corneum [0.03%]
相关激肽酶14可能是人类角质层蛋白水解活性的主要贡献者
Kristina Stefansson,Maria Brattsand,Annelii Ny et al.
Kristina Stefansson et al.
We have previously presented evidence that two human kallikrein-related peptidases, KLK5 (hK5, stratum corneum tryptic enzyme, SCTE) and KLK7 (hK7, stratum corneum chymotryptic enzyme, SCCE), which are abundant in the stratum corneum, may b...
Human kallikrein 4: enzymatic activity, inhibition, and degradation of extracellular matrix proteins [0.03%]
人溶菌酶4:酶活性,抑制作用及降解细胞外基质蛋白
Chistina V Obiezu,Iacovos P Michael,Michael A Levesque et al.
Chistina V Obiezu et al.
Human kallikrein 4 (hK4) is a member of the expanded family of human kallikreins, a group of 15 secreted proteases. While this protein has been associated with ovarian and prostate cancer prognosis, only limited functional information exist...
The human kallikrein 10 promoter contains a functional retinoid response element [0.03%]
人胰蛋白酶原10启动子包含一个功能性维甲酸反应元件
Musheng Zeng,Ying Zhang,Ishfaq Bhat et al.
Musheng Zeng et al.
Human kallikrein 10 (hK10) protein is expressed in normal breast but is significantly downregulated in a majority of invasive breast cancers. Thus, understanding how hK10 expression is regulated is of substantial significance. In this study...
Human tissue kallikrein 9: production of recombinant proteins and specific antibodies [0.03%]
人组织丝氨酸蛋白酶KLK9：重组蛋白质及特异性抗体的制备
Nader Memari,Linda Grass,Terukazu Nakamura et al.
Nader Memari et al.
Human tissue kallikreins (genes, KLKs; proteins, hKs) are a subgroup of hormonally regulated serine proteases. Two tissue kallikreins, namely hK2 and hK3 (prostate-specific antigen, PSA), are currently used as serological biomarkers of pros...
Activation and enzymatic characterization of recombinant human kallikrein 8 [0.03%]
重组人激肽原酶8的表达及其酶学性质鉴定
Tadaaki Kishi,Sylvain M Cloutier,Christoph Kündig et al.
Tadaaki Kishi et al.
Human kallikrein 8 (hK8), whose gene was originally cloned as the human ortholog of a mouse brain protease, is known to be associated with diseases such as ovarian cancer and Alzheimer's disease. Recombinant human pro-kallikrein 8 was activ...
Ying Zhang,Ishfaq Bhat,Musheng Zeng et al.
Ying Zhang et al.
Our laboratory is involved in identifying genes that can be used as early diagnostic or prognostic markers in breast cancer. We previously identified a gene (NES1) that is expressed in normal but not in transformed mammary epithelial cells ...
The role of kallikrein-related peptidases in prostate cancer: potential involvement in an epithelial to mesenchymal transition [0.03%]
前列腺癌中与激肽释放酶相关的蛋白酶的作用：在上皮间质转化中的潜在作用
Astrid K Whitbread,Tara L Veveris-Lowe,Mitchell G Lawrence et al.
Astrid K Whitbread et al.
Several members of the kallikrein-related peptidase family of serine proteases have proteolytic activities that may affect cancer progression; however, the in vivo significance of these activities remains uncertain. We have demonstrated tha...
Kallikrein-related peptidase (KLK) family mRNA variants and protein isoforms in hormone-related cancers: do they have a function? [0.03%]
激素相关癌症中的丝氨酸蛋白酶家族(KLK)mRNA剪接变体和蛋白质异构体：它们的功能意义如何？
Olivia L Tan,Astrid K Whitbread,Judith A Clements et al.
Olivia L Tan et al.
The kallikrein-related peptidase (KLK) gene family of 15 serine proteases encodes many proteins, including prostate specific antigen (PSA or KLK3), that are well described and/or are potential biomarkers for hormone-related cancers. Variant...
Recombinant kallikrein expression: site-specific integration for hK6 production in human cells [0.03%]
重组激肽原表达：人细胞中特异性整合以产生hK6
Nathalie Heuzé-Vourc&#x;h,Mireille Aïnciburu,Chris Planque et al.
Nathalie Heuzé-Vourc&#x;h et al.
Kallikreins have been implicated in carcinogenesis and are promising biomarkers for the diagnosis and follow-up of various cancers. To evaluate the functions and clinical interest of kallikreins, it is important to be able to produce them a...