Regulation of human cathepsin B by alternative mRNA splicing: homeostasis, fatal errors and cell death [0.03%]
人类组织蛋白酶B的表达受信使核糖核酸选择性剪接调节：生命平衡、致命错误和细胞死亡
Antonio Baici,Kathrin Müntener,Anna Willimann et al.
Antonio Baici et al.
One of the control mechanisms of cathepsin B biosynthesis and trafficking operates through alternative splicing of pre-mRNA. An mRNA lacking exon 2 is more efficiently translated than that containing all exons, and may be responsible for el...
Caspase-containing complexes in the regulation of cell death and inflammation [0.03%]
含半胱天冬酶的复合体在细胞死亡和炎症调控中的作用
Nele Festjens,Sigrid Cornelis,Mohamed Lamkanfi et al.
Nele Festjens et al.
Caspases are a family of cysteine proteases that are essential in the initiation and execution of apoptosis and the proteolytic maturation of inflammatory cytokines such as IL-1beta and IL-18. Caspases can be subdivided into those that have...
Kallikrein-mediated cell signalling: targeting proteinase-activated receptors (PARs) [0.03%]
激肽介导的细胞信号转导：靶向蛋白酶激活受体(PARs)
Katerina Oikonomopoulou,Kristina K Hansen,Mahmoud Saifeddine et al.
Katerina Oikonomopoulou et al.
We tested the hypothesis that human tissue kallikreins (hKs) may regulate signal transduction by cleaving and activating proteinase-activated receptors (PARs). We found that hK5, 6 and 14 cleaved PAR N-terminal peptide sequences representin...
Inhibition profiles of human tissue kallikreins by serine protease inhibitors [0.03%]
丝氨酸蛋白酶抑制剂的人组织激肽释放酶抑制谱图
Liu-Ying Luo,Weiping Jiang
Liu-Ying Luo
Accumulated evidence has shown that human tissue kallikreins (hKs), a group of 15 homologous secreted serine proteases, are novel cancer biomarkers. We report here the inhibition profiles of selected hKs, including hK5, hK7, hK8, hK11, hK12...
Comparative Study
Biological chemistry. 2006 Jun;387(6):813-6. DOI:10.1515/BC.2006.103 2006
Overexpression of the human tissue kallikrein genes KLK4, 5, 6, and 7 increases the malignant phenotype of ovarian cancer cells [0.03%]
人类组织激肽释放酶基因KLK4、5、6和7的过度表达增加了卵巢癌细胞的恶性表型
Panagiotis Prezas,Matthias J E Arlt,Petar Viktorov et al.
Panagiotis Prezas et al.
The human tissue kallikrein family of serine proteases (hK1-hK15 encoded by the genes KLK1-KLK15) is involved in several cancer-related processes. Accumulating evidence suggests that certain tissue kallikreins are part of an enzymatic casca...
Improved prostate cancer detection with a human kallikrein 11 and percentage free PSA-based artificial neural network [0.03%]
基于人蛋白酶11和百分比游离PSA的人工神经网络可提高前列腺癌的检测率
Carsten Stephan,Hellmuth-Alexander Meyer,Henning Cammann et al.
Carsten Stephan et al.
Human kallikrein 11 (hK11) was evaluated in a percentage free PSA-based artificial neural network (ANN) to reduce unnecessary prostate biopsies. Serum samples from 357 patients with (n=132) and without (n=225) prostate cancer (PCa) were ana...
The epigenetic basis for the aberrant expression of kallikreins in human cancers [0.03%]
人癌中激肽释放酶异常表达的表观遗传学基础
Georgios Pampalakis,Eleftherios P Diamandis,Georgia Sotiropoulou
Georgios Pampalakis
The tissue kallikrein gene family consists of 15 genes tandemly arranged on human chromosome 19q13.4. Most kallikrein genes are characterized by aberrant expression patterns in various human cancers, a feature that makes them ideal cancer b...
mRNA expression analysis of human kallikrein 11 (KLK11) may be useful in the discrimination of benign prostatic hyperplasia from prostate cancer after needle prostate biopsy [0.03%]
人激肽原酶11（KLK11）的mRNA表达分析在穿刺活检后的良性前列腺肥大和前列腺癌鉴别中的应用价值研究
Andreas Scorilas,Alkiviades K Gregorakis
Andreas Scorilas
Kallikrein 11 (KLK11, TLSP, hippostatin) is a member of the human kallikrein gene family, which includes PSA, KLK2 and 12 other members, all localized on chromosome 19q13.4. The aim of this study was to investigate whether KLK11 expression ...
Expression of the human kallikrein genes 10 (KLK10) and 11 (KLK11) in cancerous and non-cancerous lung tissues [0.03%]
人肾素基因10(KLK10)和11(KLK11)在肺癌组织及非癌肺组织中的表达式群
Chris Planque,Mireille Aïnciburu,Nathalie Heuzé-Vourc&#x;h et al.
Chris Planque et al.
Only one transcript for KLK10 was identified by RT-PCR in lung tissue, whereas KLK11 expressed at least four alternative transcripts. Quantitative analysis of KLK10 and KLK11 expression levels was assessed by real-time PCR, in a cohort of 4...
Multiple mechanisms underlie the aberrant expression of the human kallikrein 6 gene in breast cancer [0.03%]
人激肽原酶6基因在乳腺癌中异常表达的原因及多种机制研究
Georgios Pampalakis,Georgia Sotiropoulou
Georgios Pampalakis
Human kallikrein 6 (KLK6) was identified based on its transient upregulation in a primary breast tumor and its subsequent silencing in a metastatic tumor from the same patient. The molecular mechanism(s) underlying the deregulated expressio...