The arylhydrocarbon receptor repressor (AhRR): structure, expression, and function [0.03%]
芳烃受体阻抑物(AhRR)的结构、表达及功能
Thomas Haarmann-Stemmann,Josef Abel
Thomas Haarmann-Stemmann
The arylhydrocarbon receptor (AhR) pathway is known to be critical for cellular events, especially for those evoked by several environmental chemicals such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Whereas the function of the AhR in TC...
Evidence supporting the hypothesis that one of the main functions of the aryl hydrocarbon receptor is mediation of cell stress responses [0.03%]
支持芳烃受体主要功能是介导细胞压力反应假说的证据
Fumio Matsumura,Christoph F A Vogel
Fumio Matsumura
We have previously proposed that one of the major consequences of activation of the aryl hydrocarbon receptor (AhR) by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) could be elicitation of 'cell stress response' reactions [Matsumura, Biochem. ...
Jennifer J Schlezinger,Donghui Liu,Marganit Farago et al.
Jennifer J Schlezinger et al.
The aryl hydrocarbon receptor (AhR) is an evolutionarily conserved transcription factor bound and activated by ubiquitous environmental pollutants. Historically, the AhR has been studied for its transcriptional regulation of genes encoding ...
The impact of aryl hydrocarbon receptor signaling on matrix metabolism: implications for development and disease [0.03%]
芳烃受体信号对基质代谢的影响：对发育和疾病的启示
Jedd M Hillegass,Kyle A Murphy,Caren M Villano et al.
Jedd M Hillegass et al.
The aryl hydrocarbon receptor (AhR) was identified as the receptor for polycyclic aromatic hydrocarbons and related compounds. However, novel data indicate that the AhR binds a variety of unrelated endogenous and exogenous compounds. Althou...
Agneta Rannug,Ellen Fritsche
Agneta Rannug
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that has been intensively studied with respect to the toxicity of xenobiotics. However, its function in response to light has never been summarized. Here, we pro...
Charlotte Esser
Charlotte Esser
Isolation and comparative characterization of Ki-67 equivalent antibodies from the HuCAL phage display library [0.03%]
从HuCAL噬菌体展示文库中分离并比较鉴定与Ki-67抗原相当的抗体
Tiantom Jarutat,Christian Frisch,Cora Nickels et al.
Tiantom Jarutat et al.
It has been shown that a repetitive motif with the sequence FKEL(F) within the Ki-67 antigen (pKi-67) serves as an epitope for the Ki-67 antibody and equivalent clones. However, no direct correlation between reactivity towards Ki-67 epitope...
Isolation and properties of extracellular proteinases of Penicillium marneffei [0.03%]
马尔尼菲青霉菌胞外蛋白酶的分离及其性质研究
Jonathan L Moon,Lindsey N Shaw,John A Mayo et al.
Jonathan L Moon et al.
Penicillium marneffei is a dimorphic fungus native to Southeast Asia. Disease caused by this organism, until recently a very rare condition, has increased dramatically in parallel with the increase in the number of individuals in the region...
Inhibition of calcineurin by infusion of CsA causes hyperphosphorylation of tau and is accompanied by abnormal behavior in mice [0.03%]
环孢素灌注抑制钙调神经磷酸酶导致tau蛋白过度磷酸化并伴有小鼠异常行为
Da-yu Yu,Jing Luo,Fan Bu et al.
Da-yu Yu et al.
Calcineurin is a Ca2+/calmodulin-dependent phosphatase that dephosphorylates numerous substrates in different neuronal compartments. Genetic and pharmacological studies have provided insight into its involvement in the brain. Cyclosporin A ...
Despite its strong transactivation domain, transcription factor FOXM1c is kept almost inactive by two different inhibitory domains [0.03%]
尽管转录因子FOXM1c具有很强的反式激活结构域，但其活性却受到两个不同的抑制性结构域的影响而保持几乎处于不活跃状态
Inken Wierstra,Jürgen Alves
Inken Wierstra
FOXM1c (MPP2) is an activating transcription factor with several nuclear localization signals, a forkhead domain for DNA binding, and a very strong acidic transactivation domain. Despite its very strong transactivation domain, FOXM1c is kep...