Nicolle Bader,Tilman Grune
Nicolle Bader
One of the hallmarks of chronic or severe oxidative stress is the accumulation of oxidized proteins, which tend to form high-molecular-weight aggregates. The major proteolytic system responsible for the removal of oxidized cytosolic and nuc...
The L-arginine nitric oxide pathway: avenue for a multiple-level approach to assess vascular function [0.03%]
L-精氨酸一NO途径：多水平评估血管功能的方法学路径
Tienush Rassaf,Petra Kleinbongard,Malte Kelm
Tienush Rassaf
Endothelial dysfunction is an early stage of atherosclerosis and has been attributed to impaired nitric oxide (NO) bioactivity and enhanced formation of oxygen-derived free radicals. Given that endothelial dysfunction is at least in part re...
Jacques Pouysségur,Fatima Mechta-Grigoriou
Jacques Pouysségur
Reactive oxygen species (ROS) have long been considered only as cyto- and genotoxic. However, there is now compelling evidence that ROS also act as second messengers in response to various stimuli, such as growth factors, hormones and cytok...
Regina Brigelius-Flohé
Regina Brigelius-Flohé
Analysis of the selenoproteome identified five glutathione peroxidases (GPxs) in mammals: cytosolic GPx (cGPx, GPx1), phospholipid hydroperoxide GPx (PHGPX, GPx4), plasma GPx (pGPX, GPx3), gastrointestinal GPx (GI-GPx, GPx2) and, in humans,...
Hypoxia and lipid signaling [0.03%]
缺氧与脂质信号转导
Andrea Huwiler,Josef Pfeilschifter
Andrea Huwiler
Sufficient oxygen supply is crucial for the development and physiology of mammalian cells and tissues. When simple diffusion of oxygen becomes inadequate to provide the necessary flow of substrate, evolution has provided cells with tools to...
Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism [0.03%]
Keap1-Nrf2系统的双位点底物识别模型：铰链和门闩机制
Kit I Tong,Akira Kobayashi,Fumiki Katsuoka et al.
Kit I Tong et al.
Cells are equipped with a number of transcriptional factors that safeguard against various environmental insults. Proteasomal protein degradation plays an important role in the Keap1-Nrf2 cytoprotection system, with molecular machinery simi...
Degradation of apolipoprotein B-100 by lysosomal cysteine cathepsins [0.03%]
lysosomal胱天蛋白酶降解载脂蛋白B-100
Martin Linke,Ronald E Gordon,Michèle Brillard et al.
Martin Linke et al.
Although the degradation of cellular or endocytosed proteins comprises the normal function of lysosomal proteinases, these enzymes were also detected extracellularly during diseases such as atherosclerosis. Since lysosomal cysteine cathepsi...
A novel proteolytically processed CDP/Cux isoform of 90 kDa is generated by cathepsin L [0.03%]
天冬氨酸蛋白酶L对CDP/Cux的裂解作用生成一种新的90 ku的CDP/Cux异构体
Brigitte Goulet,Mary Truscott,Alain Nepveu
Brigitte Goulet
The Cut-like genes code for multiple isoforms of the CDP/Cux transcription factor. The full-length protein contains four DNA-binding domains: Cut repeats 1, 2 and 3 (CR1, CR2 and CR3) and the Cut homeodomain (HD). The p75 isoform is express...
Induction of intracellular signalling in human endothelial cells by the hyaluronan-binding protease involves two distinct pathways [0.03%]
人内皮细胞中透明质酸结合蛋白酶的诱导涉及两种不同的途径
Julia Anne Kress,Rainer Seitz,Johannes Dodt et al.
Julia Anne Kress et al.
Recently a novel plasma serine protease with high affinity to hyaluronic acid and glycosaminoglycans, such as heparin and heparan sulfate, has been described and termed hyaluronan-binding protease (HABP). HABP cleaves kininogen in vitro, re...