Unique neuronal functions of cathepsin L and cathepsin B in secretory vesicles: biosynthesis of peptides in neurotransmission and neurodegenerative disease [0.03%]
猫氨酸L和B在分泌泡中的独特神经元功能：神经传递和神经退行性疾病中肽的生物合成
Vivian Y H Hook
Vivian Y H Hook
Proteases are required for the production of peptide neurotransmitters and toxic peptides in neurodegenerative diseases. Unique roles of the cysteine proteases cathepsin L and cathepsin B in secretory vesicles for the production of biologic...
Incinerator fly ash provokes alteration of redox equilibrium and liberation of arachidonic acid in vitro [0.03%]
焚烧飞灰可引起体外红氧平衡的改变和花生四烯酸的释放
Susanne Fritsch,Silvia Diabaté,Harald F Krug
Susanne Fritsch
Numerous epidemiological studies have associated exposure to ambient particulate matter (PM) with pulmonary and cardiovascular health effects. Macrophages as a part of the primary pulmonary defence system play a crucial role by generating p...
Air pollution-associated fly ash particles induce fibrotic mechanisms in primary fibroblasts [0.03%]
大气污染相关的煤烟颗粒可诱导人原代成纤维细胞发生纤维化反应
Torsten Gursinsky,Stefanie Ruhs,Ulrich Friess et al.
Torsten Gursinsky et al.
Air pollution is associated with a variety of respiratory and cardiovascular disorders, including fibrosis. To understand the possible molecular mechanisms underlying this observation, we examined the effect of particulate matter on primary...
Regulatory effects of the mitochondrial energetic status on mitochondrial p66Shc [0.03%]
线粒体能量状态对线粒体p66Shc的调节作用
Francesca Orsini,Maurizio Moroni,Cristina Contursi et al.
Francesca Orsini et al.
p66(Shc) promotes apoptosis and controls the intracellular redox balance. A fraction of p66(Shc) exists within mitochondria, where it oxidizes cytochrome c to form hydrogen peroxide, which in turn induces mitochondrial permeability and apop...
Singlet oxygen inactivates protein tyrosine phosphatase-1B by oxidation of the active site cysteine [0.03%]
单线态氧通过氧化活性位点半胱氨酸使蛋白质酪氨酸磷酸酶-1B失活
Claudia von Montfort,Victor S Sharov,Sabine Metzger et al.
Claudia von Montfort et al.
Singlet oxygen ((1)O(2)), an electronically excited form of molecular oxygen, is a mediator of biological effects of ultraviolet A radiation, stimulating signaling cascades in human cells. We demonstrate here that (1)O(2) generated by photo...
Aspects of the biological redox chemistry of cysteine: from simple redox responses to sophisticated signalling pathways [0.03%]
半胱氨酸生物氧化还原化学的几个方面：从简单的氧化还原反应到复杂的信号传导通路
Claus Jacob,Iona Knight,Paul G Winyard
Claus Jacob
The last decade has witnessed an increased interest in cysteine modifications such as sulfenic and sulfinic acids, thiyl radicals, sulfenyl-amides and thiosulfinates, which come together to enable redox sensing, activation, catalysis, switc...
Charles J Lowenstein,Hiromasa Tsuda
Charles J Lowenstein
Vascular injury triggers endothelial exocytosis of granules, releasing pro-inflammatory and pro-thrombotic mediators into the blood. Nitric oxide (NO) and reactive oxygen species (ROS) limit vascular inflammation and thrombosis by inhibitin...
Teresa Laragione,Elisabetta Gianazza,Rossella Tonelli et al.
Teresa Laragione et al.
Thiols affect a variety of cell functions, an effect known as redox regulation, largely attributed to modification of transcription factors and intracellular signaling mechanisms. Since exofacial protein thiols are more exposed to redox-act...
Pathogenetic interplay between osmotic and oxidative stress: the hepatic encephalopathy paradigm [0.03%]
渗透应激和氧化应激的致病互作关系：肝性脑病为例证
Freimut Schliess,Boris Görg,Dieter Häussinger
Freimut Schliess
Hepatic encephalopathy (HE) defines a primary gliopathy associated with acute and chronic liver disease. Astrocyte swelling triggered by ammonia in synergism with different precipitating factors, including hyponatremia, tumor necrosis facto...
Stefan M Schieke,Toren Finkel
Stefan M Schieke
Growing evidence supports the concept that mitochondrial metabolism and reactive oxygen species (ROS) play a major role in aging and determination of an organism's life span. Cellular signaling pathways regulating mitochondrial activity, an...