Mast cell-dependent activation of pro matrix metalloprotease 2: A role for serglycin proteoglycan-dependent mast cell proteases [0.03%]
肥大细胞依赖性原基质金属蛋白酶2的激活：sertglycin蛋白聚糖依赖性肥大细胞蛋白酶的作用
Anders Lundequist,Magnus Abrink,Gunnar Pejler
Anders Lundequist
The formation of active matrix metalloprotease-2 (MMP-2) requires the proteolytic processing of proMMP-2, a process that can occur through the formation of a ternary complex between proMMP-2, the tissue inhibitor of metalloprotease-2 and me...
Specificity of human cathepsin S determined by processing of peptide substrates and MHC class II-associated invariant chain [0.03%]
人猫屎蛋白S特异性的测定及其肽底物和MHCⅡ类关联不变链的加工过程
Thomas Rückrich,Jens Brandenburg,Alexander Cansier et al.
Thomas Rückrich et al.
Cathepsin S (CatS) is a lysosomal cysteine protease of the papain family, the members of which possess relatively broad substrate specificities. It has distinct roles in major histocompatibility complex (MHC) class II-associated peptide loa...
The human cathelicidin peptide LL-37 and truncated variants induce segregation of lipids and proteins in the plasma membrane of Candida albicans [0.03%]
人源性抗菌多肽LL-37及其截短片段通过诱导白念珠菌细胞膜脂质与蛋白的分离发挥杀菌活性
Alice L den Hertog,Jan van Marle,Enno C I Veerman et al.
Alice L den Hertog et al.
The human cathelicidin peptide LL-37 and several truncated variants differ in their capability to transmigrate over the plasma membrane of Candida albicans. We investigated whether retention at the cell perimeter or membrane transmigration ...
First identification of a phosphorylcholine-substituted protein from Caenorhabditis elegans: isolation and characterization of the aspartyl protease ASP-6 [0.03%]
秀丽杆线虫磷胆碱修饰蛋白ASP-6的鉴定及性质研究
Günter Lochnit,Julia Grabitzki,Björn Henkel et al.
Günter Lochnit et al.
Caenorhabditis elegans is a widely accepted model system for parasitic nematodes, drug screening and developmental studies. Similar to parasitic worms, C. elegans expresses glycosphingolipids and glycoproteins carrying, in part, phosphorylc...
Papaya glutamine cyclotransferase shows a singular five-fold beta-propeller architecture that suggests a novel reaction mechanism [0.03%]
番木瓜谷氨酰基环转移酶具有独特的五重β棱柱结构，提示其可能具有一种新的反应机制
Tibisay Guevara,Noemí Mallorquí-Fernández,Raquel García-Castellanos et al.
Tibisay Guevara et al.
Cyclisation of N-terminal glutamine and/or glutamate to yield pyroglutamate is an essential posttranslational event affecting a plethora of bioactive peptides and proteins. It is directly linked with pathologies ranging from neurodegenerati...
DNA-binding properties of the recombinant high-mobility-group-like AT-hook-containing region from human BRG1 protein [0.03%]
人类BRG1蛋白重组产生的一段带有AT核苷酸序列富含区结合域的高迁移率族类似物区域的DNA结合性质
Mahavir Singh,Loyola D&#x;Silva,Tad A Holak
Mahavir Singh
The hBRG1 protein, a central ATPase of the human switching/sucrose non-fermenting (SWI/SNF) remodeling complex, has a catalytic ATPase domain, an AT-hook motif and a bromodomain. Bromodomains, found in many chromatin-associated proteins, re...
The beta12-beta13 loop is a key regulatory element for the activity and properties of the catalytic domain of protein phosphatase 1 and 2B [0.03%]
β12-β13环是蛋白磷酸酶1和2B催化结构域活性及性质的关键调节元件
Xiu-Jie Xie,Cheng-Zhe Xue,Wei Huang et al.
Xiu-Jie Xie et al.
The molecular architectures of the catalytic core of protein phosphatase 1 (PP1) and protein phosphatase 2B (PP2B) are similar, and both contain a beta12-beta13 loop that consists of non-conserved residues. A truncation mutant containing th...
Human RBM28 protein is a specific nucleolar component of the spliceosomal snRNPs [0.03%]
人类RBM28蛋白是剪接体snRNPs的特异性核仁成分蛋白质
Andrey Damianov,Michael Kann,William S Lane et al.
Andrey Damianov et al.
The biogenesis of spliceosomal small nuclear RNAs (snRNAs) involves organized translocations between the cytoplasm and certain nuclear domains, such as Cajal bodies and nucleoli. Here we identify human RBM28 protein as a novel snRNP compone...
Switch from actin alpha1 to alpha2 expression and upregulation of biomarkers for pressure overload and cardiac hypertrophy in taurine-deficient mouse heart [0.03%]
牛磺酸缺乏小鼠心肌中α1-actin向α2-actin表达的转换及压力超负荷和心室肥大的生物标志物表达增加
Ulrich Warskulat,Birgit Andrée,Jessica Lüsebrink et al.
Ulrich Warskulat et al.
Taurine is the most abundant free amino acid in heart muscle and protects against heart failure. In the present study, the consequences of hereditary taurine deficiency on cardiac gene expression were examined in 2- and 15-16-month-old taur...
Two novel mitochondrial and chloroplastic targeting-peptide-degrading peptidasomes in A. thaliana, AtPreP1 and AtPreP2 [0.03%]
拟南芥中两种新型线粒体和叶绿体定位肽酶AtPreP1和AtPreP2
Elzbieta Glaser,Stefan Nilsson,Shashi Bhushan
Elzbieta Glaser
Two novel metalloendopeptidases in Arabidopsis thaliana, AtPreP1 and AtPreP2, are responsible for the degradation of targeting peptides in mitochondria and chloroplasts. Both AtPreP1 and AtPreP2 contain ambiguous targeting peptides and are ...