Raphael Stoll,Sibylla Lodermeyer,Anja-Katrin Bosserhoff
Raphael Stoll
MIA (melanoma inhibitory activity) has been identified as a small protein secreted by malignant melanoma cells that interacts with extracellular matrix proteins including fibronectin. These findings suggest that MIA may play a role in tumor...
Fes1p acts as a nucleotide exchange factor for the ribosome-associated molecular chaperone Ssb1p [0.03%]
Fes1p充当核苷酸交换因子以激活与核糖体结合的分子伴侣Ssb1p
Zdravko Dragovic,Yasuhito Shomura,Nikolay Tzvetkov et al.
Zdravko Dragovic et al.
The HspBP1 homolog Fes1p was recently identified as a nucleotide exchange factor (NEF) of Ssa1p, a canonical Hsp70 molecular chaperone in the cytosol of Saccharomyces cerevisiae. Besides the Ssa-type Hsp70s, the yeast cytosol contains three...
The human malaria parasite Plasmodium falciparum expresses an atypical N-terminally extended pyrophosphokinase with specificity for thiamine [0.03%]
疟原虫表达一种非典型的核糖体延长的焦磷酸酶具有对维生素B1起作用的特异性
Marie-Luise Eschbach,Ingrid B Müller,Tim-Wolf Gilberger et al.
Marie-Luise Eschbach et al.
Vitamin B(1) is an essential cofactor for key enzymes such as 2-oxoglutarate dehydrogenase and pyruvate dehydrogenase. Plants, bacteria and fungi, as well as Plasmodium falciparum, are capable of synthesising vitamin B(1)de novo, whereas ma...
Evaluation of Bacillus anthracis thymidine kinase as a potential target for the development of antibacterial nucleoside analogs [0.03%]
芽孢杆菌安替普林胸苷激酶作为抗菌核苷类似物开发潜在靶点的评估研究
Cecilia Carnrot,Susan R Vogel,Youngjoo Byun et al.
Cecilia Carnrot et al.
Bacillus anthracis, which causes anthrax, has attracted attention because of its potential use as a biological weapon. The risk of multidrug resistance against B. anthracis increases the need for antibiotics with new molecular targets. Nucl...
Mutations in the inter-SH2 domain of the regulatory subunit of phosphoinositide 3-kinase: effects on catalytic subunit binding and holoenzyme function [0.03%]
调节亚基中的互SH2结构域和磷脂肌醇3-激酶的催化亚基结合及全酶功能的突变研究
Winfried Elis,Eva Lessmann,Michael Oelgeschlager et al.
Winfried Elis et al.
Class IA phosphoinositide 3-kinases (PI3Ks) represent a group of heterodimeric lipid kinases with important functions in cellular signal transduction. The regulatory p85 subunit constitutively binds to the catalytic p110 subunit and mediate...
Heterogeneity in the cysteine protease inhibitor clitocypin gene family [0.03%]
半胱氨酸蛋白酶抑制剂基因家族的异质性研究
Jerica Sabotic,Dominik Gaser,Boris Rogelj et al.
Jerica Sabotic et al.
Clitocypin from the basidiomycete Clitocybe nebularis is the first fungal protein cysteine protease inhibitor to be characterised in detail, yet no information on its molecular genetics is available. Owing to its unique characteristics, it ...
Ann E Frazier,Clement Kiu,Diana Stojanovski et al.
Ann E Frazier et al.
It is now appreciated that mitochondria form tubular networks that adapt to the requirements of the cell by undergoing changes in their shape through fission and fusion. Proper mitochondrial distribution also appears to be required for ATP ...
Endogenous anti-inflammatory substances, inter-alpha-inhibitor and bikunin [0.03%]
内源性抗炎物质间-α抑制蛋白和白金素
Hiroshi Kobayashi
Hiroshi Kobayashi
There have been new developments in the elucidation of the biological functions of the inter-alpha-inhibitor (IalphaI) family. The anti-proteolytic activity of the IalphaI family originates from bikunin (also known as urinary trypsin inhibi...
Mikiko Matsui,Jonathan H Fowler,Linda L Walling
Mikiko Matsui
Leucine aminopeptidases (LAPs) are metallopeptidases that cleave N-terminal residues from proteins and peptides. While hydrolyzing Leu substrates, LAPs often have a broader specificity. LAPs are members of the M1 or M17 peptidase families, ...
Janus-faced role of endothelial NO synthase in vascular disease: uncoupling of oxygen reduction from NO synthesis and its pharmacological reversal [0.03%]
内皮一氧化氮合酶在血管疾病中的双重作用：氧气还原与一氧化氮合成的脱偶联及其药物逆转作用
Ulrich Förstermann
Ulrich Förstermann
Endothelial NO synthase (eNOS) is the predominant enzyme responsible for vascular NO synthesis. A functional eNOS transfers electrons from NADPH to its heme center, where L-arginine is oxidized to L-citrulline and NO. Common conditions pred...