Presence of the propeptide on recombinant lysosomal dipeptidase controls both activation and dimerization [0.03%]
lysosomal二肽酶的プロプレッピドとその機能構造に関する研究
Iztok Dolenc,Roger Pain,Vito Turk
Iztok Dolenc
Lysosomal dipeptidase catalyzes the hydrolysis of dipeptides with unsubstituted terminals. It is a homodimer and binds zinc. Dimerization is an important issue in understanding the enzyme's function. In this study, we investigated the influ...
Characterisation of YtfM, a second member of the Omp85 family in Escherichia coli [0.03%]
Ecoli中OMP85家族的第二个成员YtfM的性质研究
Johannes F Stegmeier,Andreas Glück,Suja Sukumaran et al.
Johannes F Stegmeier et al.
Omp85 proteins form a ubiquitous protein family, members of which are found in all Gram-negative bacteria. Omp85 of Neisseria meningitidis and YaeT of Escherichia coli are shown to be essential for outer membrane biogenesis. Interestingly, ...
Structural modifications to a high-activity binding peptide located within the PfEMP1 NTS domain induce protection against P. falciparum malaria in Aotus monkeys [0.03%]
在绒猴中对高活性结合肽进行结构修饰可诱导对恶性疟原虫的保护作用：位于PfEMP1NTS区内的一个例子
Hernando Curtidor,Mary Helena Torres,Martha Patricia Alba et al.
Hernando Curtidor et al.
Binding of P. falciparum-infected erythrocytes to vascular endothelium and to uninfected erythrocytes is mediated by the parasite-derived variant erythrocyte membrane protein PfEMP-1 and various receptors, both on the vascular endothelium a...
Characterisation of Plasmodium falciparum RESA-like protein peptides that bind specifically to erythrocytes and inhibit invasion [0.03%]
表征能够特异性结合红细胞和抑制入侵的恶性疟原虫RESA样蛋白肽
Luis Eduardo Rodriguez,Ricardo Vera,John Valbuena et al.
Luis Eduardo Rodriguez et al.
The Plasmodium falciparum ring-erythrocyte surface antigen (RESA)-like putative protein was identified and characterised. PCR and RT-PCR assays revealed that the gene encoding this protein was both present and being transcribed in P. falcip...
Accumulation of viroid-specific small RNAs and increase in nucleolytic activities linked to viroid-caused pathogenesis [0.03%]
与类病毒引起的病害相关的病毒粒体特异性小RNA的积累及核酸酶活性的增加
Jaroslav Matousek,Petra Kozlová,Lidmila Orctová et al.
Jaroslav Matousek et al.
Strong viroid-caused pathogenesis was achieved in tomato cv. Rutgers by biolistic transfer of severe or lethal potato spindle tuber viroid (PSTVd) strains, while other tomato genotypes (e.g., Moneymaker) were tolerant. With reciprocal hybri...
Two secreted cystatins of the soft tick Ornithodoros moubata: differential expression pattern and inhibitory specificity [0.03%]
硬蜱Ornithodoros moubata的两种分泌型胱抑素：不同的表达模式和抑制特异性
Lenka Grunclová,Martin Horn,Marie Vancová et al.
Lenka Grunclová et al.
Two genes coding for cysteine peptidase inhibitors of the cystatin family (Om-cystatin 1 and 2) were isolated from a gut-specific cDNA library of the soft tick Ornithodoros moubata. Both cystatins were clearly down-regulated after a blood m...
Topotecan and methotrexate alter expression of the apoptosis-related genes BCL2, FAS and BCL2L12 in leukemic HL-60 cells [0.03%]
托泊替康和甲氨蝶呤通过改变BCL2，FAS及BCL2L12基因的表达来诱导白血病HL-60细胞凋亡
Kostas V Floros,Maroulio Talieri,Andreas Scorilas
Kostas V Floros
The BCL2 family of genes (B-cell CLL/lymphoma 2; Bcl-2) plays a pivotal role in the highly regulated process of apoptosis. We have recently cloned a newly identified member of this family, BCL2L12, which was found to be differentially expre...
Suppression of TNF-alpha production by S-adenosylmethionine in human mononuclear leukocytes is not mediated by polyamines [0.03%]
牛磺酸甲基硫氨酸抑制人类单核淋巴细胞中的TNF-α产生作用与多胺无关
Jingling Yu,Senja Sauter,Alexandr Parlesak
Jingling Yu
Endotoxin-induced cytokine production is an important mechanism in the development of several types of liver damage. Methionine, some of its precursors and metabolites were reported to have protective effects against such injury. The aim of...
Prognostic significance of the expression of SR-A1, encoding a novel SR-related CTD-associated factor, in breast cancer [0.03%]
SR-A1表达与乳腺癌的关系及意义研究
Theoni Leoutsakou,Maroulio Talieri,Andreas Scorilas
Theoni Leoutsakou
SR-A1 is a human high-molecular-weight SR-related CTD-associated factor that links the machineries of transcription and mRNA splicing. In this study we examined the prognostic value of SR-A1 gene expression using a semi-quantitative RT-PCR ...
The role of human tissue kallikreins 7 and 8 in intracranial malignancies [0.03%]
人组织 kal 利特酶 7 和 8 在颅内恶性肿瘤中的作用
Panagiotis Prezas,Andreas Scorilas,Christina Yfanti et al.
Panagiotis Prezas et al.
Recent evidence suggests that many tissue kallikreins are implicated in carcinogenesis. Kallikrein 8 (KLK8) plays a role in the physiology of the central nervous system. Kallikrein 7 (KLK7) takes part in skin desquamation. Both show altered...