Short double-stranded RNAs of specific sequence activate ribosomal TAK1-D and induce a global inhibition of translation [0.03%]
特定序列的短双链RNA激活核糖体TAK1-D并引起全局性翻译抑制
Reinhard Kodym,Elisabeth Kodym,Michael D Story
Reinhard Kodym
We have previously shown that short double-stranded RNAs of specific sequence induce phosphorylation in the activation loop of splicing variant D of the transforming growth factor beta-activated protein kinase 1 (TAK1-D). Here, we further c...
Christina Bleckmann,Hildegard Geyer,Annika Lieberoth et al.
Christina Bleckmann et al.
The cell adhesion molecule CD24 is a highly glycosylated glycoprotein that plays important roles in the central nervous system, the immune system and in tumor biology. Since CD24 comprises only a short protein core of approximately 30 amino...
Flavivirus NS5 associates with host-cell proteins zonula occludens-1 (ZO-1) and regulating synaptic membrane exocytosis-2 (RIMS2) via an internal PDZ binding mechanism [0.03%]
flavivirus ns5 通过内部 pdz 结合机制与宿主细胞蛋白zonula occludens-1(z0-1) 和调节突触胞吐作用-2(rims2) 相互作用
Karin Ellencrona,Asim Syed,Magnus Johansson
Karin Ellencrona
Dengue virus (DENV) and tick-borne encephalitis virus (TBEV) are flaviviruses, which can cause lethal hemorrhagic fever and encephalitis, respectively. Here, we demonstrate that the TBEV-NS5 and DENV-NS5 proteins use an internal binding mec...
Amidinoanthracyclines - a new group of potential anti-hepatitis C virus compounds [0.03%]
氨基蒽环类化合物——一类潜在的抗丙型肝炎病毒新化合物
Mariusz Krawczyk,Malgorzata Wasowska-Lukawska,Irena Oszczapowicz et al.
Mariusz Krawczyk et al.
Hepatitis C virus (HCV) infections represent one of the major and still unresolved health problems because current therapy is effective in only 50-80% of cases, depending on viral genotype. A large group of amidinoanthracyclines, with decre...
Significance of the cyclic structure and of arginine residues for the antibacterial activity of arenicin-1 and its interaction with phospholipid and lipopolysaccharide model membranes [0.03%]
环状结构和精氨酸残基对 Arenicin-1 的抗菌活性及其与磷脂和脂多糖模型膜相互作用的意义
Jörg Andrä,Malte U Hammer,Joachim Grötzinger et al.
Jörg Andrä et al.
Arenicin-1 (Ar-1) is a beta-sheeted antimicrobial peptide from the marine lugworm Arenicola marina. To elucidate the significance of its unique 18-residue cyclic structure and of six cationic arginines for its biological activity and its in...
Interaction of human heat shock protein 70 with tumor-associated peptides [0.03%]
人热休克蛋白70与肿瘤相关肽的相互作用
Maya J Pandya,Henriette Bendz,Florian Manzenrieder et al.
Maya J Pandya et al.
Molecular chaperones of the heat shock protein 70 (Hsp70) family play a crucial role in the presentation of exogenous antigenic peptides by antigen-presenting cells (APCs). In a combined biochemical and immunological approach, we characteri...
Structure-function relationship of the human antimicrobial peptide LL-37 and LL-37 fragments in the modulation of TLR responses [0.03%]
人抗菌肽LL-37及LL-37片段调节TLR应答的结构功能关系研究
E Margo Molhoek,Alice L den Hertog,Anne-Marij B C de Vries et al.
E Margo Molhoek et al.
Cathelicidins are effector molecules of the innate host defense system that establish an antimicrobial barrier at epithelial interfaces. The human cathelicidin LL-37, in addition to its antimicrobial activity, also exhibits immunomodulatory...
Co-expression of 9-O-acetylated sialoglycoproteins and their binding proteins on lymphoblasts of childhood acute lymphoblastic leukemia: an anti-apoptotic role [0.03%]
儿童急性淋巴细胞白血病淋巴母细胞中9-O-乙酰化唾液酸糖蛋白的共表达及其结合蛋白的作用：抗凋亡作用
Kankana Mukherjee,Anil K Chava,Suman Bandyopadhyay et al.
Kankana Mukherjee et al.
Enhanced levels of 9-O-acetylated sialoglycoproteins (Neu5,9Ac(2)GPs) as disease-associated molecules was reported to act as signaling molecules for promoting survival of lymphoblasts in childhood acute lymphoblastic leukemia (ALL). Here, w...
Central nervous system: cholesterol turnover, brain development and neurodegeneration [0.03%]
中枢神经系统：胆固醇周转、大脑发育和神经退行性病变
John M Dietschy
John M Dietschy
The average amount of cholesterol in the whole animal equals approximately 2100 mg/kg body weight, and 15% and 23% of this sterol in the mouse and human, respectively, is found in the central nervous system. There is no detectable uptake ac...
Two aspartic proteinases secreted by the pathogenic yeast Candida parapsilosis differ in expression pattern and catalytic properties [0.03%]
病原酵母克柔假丝酵母菌分泌的两种天冬氨酸蛋白酶在表达模式和催化特性上有所不同
Olga Hrusková-Heidingsfeldová,Jirí Dostál,Filip Majer et al.
Olga Hrusková-Heidingsfeldová et al.
Secreted aspartic proteinases (Sap) play a role in the virulence of pathogenic Candida spp. Candida parapsilosis possesses three genes encoding these enzymes: SAPP1, SAPP2, and SAPP3. We analyzed the expression of the SAPP1 and SAPP2 genes ...