HIRIP3 is a nuclear phosphoprotein interacting with and phosphorylated by the serine-threonine kinase CK2 [0.03%]
Hirip3是一种与蛋白激酶CK2相互作用并被CK2磷酸化的核磷蛋白
Nadine Assrir,Odile Filhol,Frédéric Galisson et al.
Nadine Assrir et al.
The HIRIP3 protein had been identified from its interaction with the HIRA histone chaperone. Experiments using anti-peptide antisera indicated that this 556-aa protein is nuclear throughout the cell cycle and excluded from condensed chromat...
Frank J Kaiser,Hermann-Josef Lüdecke,Stefan Weger
Frank J Kaiser
Mutations or deletions of the TRPS1 gene on human chromosome 8q.24.1 cause the tricho-rhino-phalangeal syndromes (TRPS), which are characterized by craniofacial and skeletal malformations. The gene encodes a transcription factor that functi...
Glutamic acid-141: a heme 'bodyguard' in anionic tobacco peroxidase [0.03%]
谷氨酸-141：阴离子烟草漆酶的“护血红素”氨基酸
Dmitri M Hushpulian,Andrew A Poloznikov,Pavel A Savitski et al.
Dmitri M Hushpulian et al.
The role of the conserved glutamic acid residue in anionic plant peroxidases with regard to substrate specificity and stability was examined. A Glu141Phe substitution was generated in tobacco anionic peroxidase (TOP) to mimic neutral plant ...
N.BspD6I DNA nickase strongly stimulates template-independent synthesis of non-palindromic repetitive DNA by Bst DNA polymerase [0.03%]
N.BspD6I 核酸酶强烈刺激BstDNA聚合酶模板无关的非回文重复序列DNA合成
Nadezhda V Zyrina,Lyudmila A Zheleznaya,Eugene V Dvoretsky et al.
Nadezhda V Zyrina et al.
Highly efficient DNA synthesis without template and primer DNAs occurs when N.BspD6I DNA nickase is added to a reaction mixture containing deoxynucleoside triphosphates and the large fragment of Bst DNA polymerase. Over a period of 2 h, vir...
Localization and organization of protein factors involved in chromosome inheritance in Dictyostelium discoideum [0.03%]
调控黏菌染色体分离的蛋白质定位及其作用机制研究
Markus Kaller,Balint Földesi,Wolfgang Nellen
Markus Kaller
Heterochromatin protein 1 (HP1) proteins are highly conserved heterochromatin components required for genomic integrity. We have previously shown that the two HP1 isoforms expressed in Dictyostelium, HcpA and HcpB, are mainly localized to (...
Transgenic mouse brains for the evaluation and quality control of BSE tests [0.03%]
用于评价和检测疯牛病的质量控制的转基因鼠脑
Wolfgang J Philipp,Darlene Groth,Kurt Giles et al.
Wolfgang J Philipp et al.
Rapid BSE tests are widely used diagnostics in veterinary medicine and more than 11 million tests are applied worldwide. The evaluation of new rapid BSE tests and the quality assurance of approved BSE tests pose a challenge owing to the nat...
Human dipeptidyl peptidase III acts as a post-proline-cleaving enzyme on endomorphins [0.03%]
人二肽基-peptidase III作为内源性摩尔啡肽C端脯氨酸残基的特异性切割酶
Marina Barsun,Nina Jajcanin,Bojana Vukelić et al.
Marina Barsun et al.
Dipeptidyl peptidase III (DPP III) is a zinc exopeptidase with an implied role in the mammalian pain-modulatory system owing to its high affinity for enkephalins and localisation in the superficial laminae of the spinal cord dorsal horn. Ou...
Compartmentalised expression of meprin in small intestinal mucosa: enhanced expression in lamina propria in coeliac disease [0.03%]
小肠粘膜中meprin的分隔表达：在乳糜泻中的固有层表达增强
Daniel Lottaz,Caroline Buri,Giovanni Monteleone et al.
Daniel Lottaz et al.
Epithelial cells in the human small intestine express meprin, an astacin-like metalloprotease, which accumulates normally at the brush border membrane and in the gut lumen. Therefore, meprin is targeted towards luminal components. In coelia...
Effects of disease-modifying anti-rheumatic drugs (DMARDs) on the activities of rheumatoid arthritis-associated cathepsins K and S [0.03%]
疾病改善抗风湿药(DMARDs)对类风湿关节炎相关组织蛋白酶K和S活性的影响
Enrico Weidauer,Yoshiyuki Yasuda,Bichitra K Biswal et al.
Enrico Weidauer et al.
Rheumatoid arthritis is an inflammatory and disabling joint disease affecting 0.5-1.5% of the population. Although various anti-inflammatory (NSAIDs) and disease-modifying (DMARDs) drugs are in clinical use, their precise mechanisms of acti...
Specific inhibition of interleukin-13 activity by a recombinant human single-chain immunoglobulin domain directed against the IL-13 receptor alpha1 chain [0.03%]
一种重组人单链免疫球蛋白通过作用于IL-13受体α1链特异性抑制IL-13活性
Stefan Knackmuss,Sebastian Krause,Kathrin Engel et al.
Stefan Knackmuss et al.
Interleukin-13 (IL-13) is a T-cell-derived pleiotropic cytokine of particular medical importance because of its critical role in the development of allergic asthma. The effects of IL-13 on its target cells are mediated through a dimeric tra...