Expression of the protein phosphatase 1 inhibitor KEPI is downregulated in breast cancer cell lines and tissues and involved in the regulation of the tumor suppressor EGR1 via the MEK-ERK pathway [0.03%]
乳腺癌细胞系和组织中蛋白磷酸酶1抑制因子KEPI的表达下调并通过MEK-ERK通路参与肿瘤抑制因子EGR1的调控
Katrin Wenzel,Katjana Daskalow,Florian Herse et al.
Katrin Wenzel et al.
KEPI is a protein kinase C-potentiated inhibitory protein for type 1 Ser/Thr protein phosphatases. We found no or reduced expression of KEPI in breast cancer cell lines, breast tumors and metastases in comparison to normal breast cell lines...
Calcium signalling in the regulation of PGC-1alpha, PDK4 and HKII mRNA expression [0.03%]
钙信号在PGC-1α、PDK4和HKII mRNA表达调节中的作用
Keiko Kusuhara,Klavs Madsen,Lotte Jensen et al.
Keiko Kusuhara et al.
The role of calcium signalling and specific intracellular calcium signalling pathways in regulating skeletal muscle tissue peroxisome proliferator-activated receptor gamma co-activator (PGC)-1alpha, hexokinase (HK)II and pyruvate dehydrogen...
Characterization of peptidyl-tRNA hydrolase encoded by open reading frame Rv1014c of Mycobacterium tuberculosis H37Rv [0.03%]
结核分枝杆菌H37Rv株Rv1014c开放阅读框编码的肽基-tRNA水解酶的性质研究
Naresh C Bal,Himanshu Agrawal,Akshaya K Meher et al.
Naresh C Bal et al.
The enzyme peptidyl-tRNA hydrolase (Pth, EC 3.1.1.29) is essential for the viability of bacteria. The ORF Rv1014c of Mycobacterium tuberculosis H37Rv, designated as the mtpth gene, was cloned and over-expressed and the product was purified....
Mid-region parathyroid hormone-related protein (PTHrP) and gene expression of MDA-MB231 breast cancer cells [0.03%]
MDA-MB231乳腺癌细胞的中区甲状旁腺激素相关蛋白(Pthrp)及其基因表达
Rosalia Sirchia,Claudio Luparello
Rosalia Sirchia
We have previously shown that PTHrP(38-94) amide restrains growth and invasion in vitro, causes striking toxicity and accelerates death of some breast cancer cell lines, the most responsive being MDA-MB231, for which tumorigenesis was also ...
Neprilysin carboxydipeptidase specificity studies and improvement in its detection with fluorescence energy transfer peptides [0.03%]
宁普利辛羧肽酶特异性的研究及利用荧光共振能量转移底物改进其检测方法
Nilana M T Barros,Marcelo Campos,Patrícia A Bersanetti et al.
Nilana M T Barros et al.
We examined the substrate specificity of the carboxydipeptidase activity of neprilysin (NEP) using fluorescence resonance energy transfer (FRET) peptides containing ortho-aminobenzoyl (Abz) and 2,4-dinitrophenyl (Dnp) as a donor/acceptor pa...
Down-regulation of human extracellular cysteine protease inhibitors by the secreted staphylococcal cysteine proteases, staphopain A and B [0.03%]
金黄色葡萄球菌细胞外半胱氨酸蛋白酶staphopainA和B下调人皮膚的丝氨酶抑制剂的研究
Bjarne Vincents,Patrik Onnerfjord,Milosz Gruca et al.
Bjarne Vincents et al.
Of seven human cystatins investigated, none inhibited the cysteine proteases staphopain A and B secreted by the human pathogen Staphylococcus aureus. Rather, the extracellular cystatins C, D and E/M were hydrolyzed by both staphopains. Base...
Enzymatic properties of human kallikrein-related peptidase 12 (KLK12) [0.03%]
人KLK12（KLKRelatedPeptidase12）酶学性质的研究
Nader Memari,Weiping Jiang,Eleftherios P Diamandis et al.
Nader Memari et al.
Human kallikrein-related peptidase 12 (KLK12) is a new member of the human tissue kallikrein family. Preliminary studies suggest that KLK12 is differentially expressed in breast cancer and may have potential use as a cancer biomarker. It ha...
Characterisation of novel splicing variants of the tyrosine hydroxylase C-terminal domain in human neuroblastic tumours [0.03%]
人神经母细胞瘤中多巴脱羧酶C端结构变异体的特征分析研究
Josep Roma,Ester Saus,Marc Cuadros et al.
Josep Roma et al.
Alternative splicing of human tyrosine hydroxylase (hTH) transcripts appears to occur mainly in the N-terminal domain, giving rise to at least eight different isoforms. We recently reported the existence of hTH transcript variants resulting...
Obesity resistance of the stearoyl-CoA desaturase-deficient (scd1-/-) mouse results from disruption of the epidermal lipid barrier and adaptive thermoregulation [0.03%]
脂肪酰辅酶A脱氢酶缺陷小鼠抵抗肥胖是由于表皮脂质屏障和体温调节适应异常所致
Erika Binczek,Britta Jenke,Barbara Holz et al.
Erika Binczek et al.
Targeted deletion of the stearoyl-CoA desaturase 1 gene (scd1) in mouse causes obesity resistance and a severe skin phenotype. Here, we demonstrate that SCD1 deficiency disrupts the epidermal lipid barrier and leads to uncontrolled transepi...
Insulin-regulated aminopeptidase: analysis of peptide substrate and inhibitor binding to the catalytic domain [0.03%]
胰岛素调节的氨基肽酶：底物和抑制剂与催化结构域结合的研究
Siying Ye,Siew Yeen Chai,Rebecca A Lew et al.
Siying Ye et al.
Peptide inhibitors of insulin-regulated aminopeptidase (IRAP) accelerate spatial learning and facilitate memory retention and retrieval by binding competitively to the catalytic site of the enzyme and inhibiting its catalytic activity. IRAP...