Characterization of rat BLOS2/Ceap, a putative yeast She3 homolog, as interaction partner of apoptosis antagonizing transcription factor/Che-1 [0.03%]
大鼠BLOS2/Ceap的特性分析：一种假定的酵母She3同源物，与凋亡拮抗转录因子/Che-1相互作用的伙伴蛋白质
Andrea Felten,Peter Leister,Sven Burgdorf et al.
Andrea Felten et al.
AATF/Che-1 is a coactivator of several transcription factors, including steroid hormone receptors. In search of novel interaction partners of AATF, we identified BLOS2 (BLOC1S2, also termed Ceap) from a rat cDNA library. BLOS2 is extremely ...
Anti-innexin 2 aptamers specifically inhibit the heterologous interaction of the innexin 2 and innexin 3 carboxyl-termini in vitro [0.03%]
反Innexin 2核糖核酸酶专门抑制异源Innexin 2和Innexin 3羧基末端相互作用体外实验
Martin Knieps,Sonja Herrmann,Corinna Lehmann et al.
Martin Knieps et al.
We recently demonstrated that heteromerization of innexins 2 and 3 from Drosophila melanogaster (Dm) is crucial for epithelial organization and polarity of the embryonic epidermis. Both innexins are thought to interact via their C-terminal ...
Lysosomal cysteine cathepsins: signaling pathways in apoptosis [0.03%]
溶酶体半胱氨酸类天冬氨酰特异性的蛋白水解酶在细胞凋亡过程中的信号转导路径研究
Veronika Stoka,Vito Turk,Boris Turk
Veronika Stoka
Apoptosis is the major mechanism by which eukaryotic organisms eliminate potentially dangerous, superfluous and damaged cells. Initially, nuclei and mitochondria were found to be the key organelles involved in the process. However, recent d...
Clinical chemistry reference database for Wistar rats and C57/BL6 mice [0.03%]
威斯特大鼠和C57/BL6小鼠临床化学参考数据库
Olaf Boehm,Berndt Zur,Alexander Koch et al.
Olaf Boehm et al.
Clinical chemistry data are decisive for evaluating altered organ function or damage in experimental animals. Few publications provide reliable clinical chemistry reference intervals, and analytical methods are often not described. Here, we...
Roberta E Burden,Philip Snoddy,Caroline A Jefferies et al.
Roberta E Burden et al.
The N-terminal propeptide domains of several cathepsin L-like cysteine proteases have been shown to possess potent inhibitory activity. Here we report the first kinetic characterisation of the inhibition properties of the cathepsin V propep...
Increase in kinins on post-exercise hypotension in normotensive and hypertensive volunteers [0.03%]
正常血压和高血压受试者运动后低血压时激肽增加现象
Milton R Moraes,Reury F P Bacurau,João D S Ramalho et al.
Milton R Moraes et al.
Post-exercise hypotension is an important event for blood pressure regulation, especially in hypertensive individuals. Although post-exercise hypotension is a well-known phenomenon, the mechanism responsible is still unclear. The kallikrein...
Clinical Trial
Biological chemistry. 2007 May;388(5):533-40. DOI:10.1515/BC.2007.055 2007
Two alpha subunits and one beta subunit of meprin zinc-endopeptidases are differentially expressed in the zebrafish Danio rerio [0.03%]
斑马鱼Danio rerio中两种α亚基和一种β亚基的meprin锌内肽酶差异表达
Andre Schütte,Daniel Lottaz,Erwin E Sterchi et al.
Andre Schütte et al.
Meprins are members of the astacin family of metalloproteases expressed in epithelial tissues, intestinal leukocytes and certain cancer cells. In mammals, there are two homologous subunits, which form complex glycosylated disulfide-bonded h...
The protease domain of procollagen C-proteinase (BMP1) lacks substrate selectivity, which is conferred by non-proteolytic domains [0.03%]
蛋白酶结构域缺乏底物选择性，而非酶催化结构域决定其底物选择性
Carsten Wermter,Markus Höwel,Vera Hintze et al.
Carsten Wermter et al.
Procollagen C-proteinase (PCP) removes the C-terminal pro-peptides of procollagens and also processes other matrix proteins. The major splice form of the PCP is termed BMP1 (bone morphogenetic protein 1). Active BMP1 is composed of an astac...
Discovery and characterization of human antibody inhibitors of pregnancy-associated plasma protein-A [0.03%]
人胎盘相关血浆蛋白A抑制抗体的发现与表征
Ting Chen,Shannon Hogan,Greg Conley et al.
Ting Chen et al.
Pregnancy-associated plasma protein-A (PAPP-A) is a metalloprotease that cleaves insulin-like growth factor-binding proteins (IGFBPs) to release bioactive levels of free insulin-like growth factor. Specific and potent inhibitors of PAPP-A m...
Nitric oxide modulates expression of extracellular matrix genes linked to fibrosis in kidney mesangial cells [0.03%]
一氧化氮可调节肾球细胞中与纤维化相关的一些细胞外基质基因的表达
Javid Wani,Marina Carl,Anna Henger et al.
Javid Wani et al.
Mesangial cells are thought to be important mediators of glomerular inflammation and fibrosis. Studies have established a direct role for nitric oxide (NO) in the regulation of gene expression in mesangial cells. Representational difference...