Thomas R Cech
Thomas R Cech
Christian Hammann,Roland K Hartmann,Anita Marchfelder
Christian Hammann
Selection of vimentin-specific antibodies from the HuCAL phage display library by subtractive panning on formalin-fixed, paraffin-embedded tissue [0.03%]
利用福尔马林固定石蜡包埋组织进行减法筛选从而从HuCAL噬菌体展示文库中选择波形蛋白特异性抗体
Tiantom Jarutat,Cora Nickels,Christian Frisch et al.
Tiantom Jarutat et al.
We describe the direct isolation of specific antibodies on formalin-fixed, paraffin-embedded (FFPE) tissue. The technique involves subtractive selection of a large and highly diverse combinatorial human antibody phage library (HuCAL) on lym...
Increased carcinogenic potential of myeloid tumor cells induced by aberrant TGF-beta1-signaling and upregulation of cathepsin B [0.03%]
异常TGF-β1信号诱导的髓系肿瘤细胞的致癌潜能增强及猫淋巴素B的上调
Anita Reisenauer,Oliver Eickelberg,Aline Wille et al.
Anita Reisenauer et al.
The TGF-beta signaling pathways are implicated in cancer. Cysteine cathepsins can contribute to the carcinogenic potential of tumor cells. The aim of this study was to investigate the regulation of cysteine cathepsin expression by TGF-beta1...
Inhibition of inducible tumor necrosis factor-alpha expression by the fungal epipolythiodiketopiperazine gliovirin [0.03%]
真菌表皮硫缩酮二肽环化合物Gliovirin抑制诱导型肿瘤坏死因子-α的表达
Jan Rether,Annegret Serwe,Timm Anke et al.
Jan Rether et al.
TNF-alpha is a major pro-inflammatory cytokine that regulates further cytokine induction, especially of IL-1 and IL-6, in many human diseases including cancer, inflammation and immune disorders. In a search for new inhibitors of inducible T...
Development of an assay for the intermembrane transfer of cholesterol by Niemann-Pick C2 protein [0.03%]
开发一种测定尼曼匹克C2蛋白间膜胆固醇转移的测定法
Jonathan O Babalola,Michaela Wendeler,Bernadette Breiden et al.
Jonathan O Babalola et al.
Niemann-Pick type C disease is an inherited fatal disorder characterized by the accumulation of unesterified cholesterol and other lipids in the endosomal/lysosomal compartment. Two independent genes responsible for this neurodegenerative d...
Competitive displacement of full-length HIV-1 Nef from the Hck SH3 domain by a high-affinity artificial peptide [0.03%]
竞争性置换HIV-1全长Nef与Hck SH3结构域的相互作用：利用高亲和力人工多肽实现
Thomas Stangler,Tuyen Tran,Silke Hoffmann et al.
Thomas Stangler et al.
We studied the interaction of the artificial 12-aa proline-rich peptide PD1 with the SH3 domain of the hematopoietic cell kinase Hck and the peptide's potency in competitively displacing HIV-1 Nef from the Hck SH3 domain. PD1 was obtained f...
Annexin B1 from Taenia solium metacestodes is a newly characterized member of the annexin family [0.03%]
猪带绦虫囊尾蚴annexin b1是annexin家族的新成员
Yi Zhang,Kai-Hui Wang,Ying-Jun Guo et al.
Yi Zhang et al.
We previously reported cloning of the Taenia solium annexin B1 gene from a metacestode cDNA expression library and demonstrated that it acts as a protective antigen for effective vaccine development against cysticercosis. In the present stu...
Characterisation of two calmodulin-like proteins from the liver fluke, Fasciola hepatica [0.03%]
肝片形吸虫钙调素样蛋白的性质研究
Sean L Russell,Neil V McFerran,Elizabeth M Hoey et al.
Sean L Russell et al.
Calmodulin is a calcium ion-sensing signalling protein found in eukaryotics. Two calmodulin-like gene sequences were identified in an EST library from adult liver flukes. One codes for a protein (FhCaM1) homologous to mammalian calmodulins ...
Irradiation of GAPDH: a model for environmentally induced protein damage [0.03%]
辐照GAPDH：环境诱导蛋白质损伤的模型
Peter Voss,Hossein Hajimiragha,Martina Engels et al.
Peter Voss et al.
Environmental factors, including sunlight, are able to induce severe oxidative protein damage. The modified proteins are either repaired, degraded or escape from degradation and aggregate. In the present study we tested the effect of differ...
Comparative Study
Biological chemistry. 2007 Jun;388(6):583-92. DOI:10.1515/BC.2007.068 2007