The structure of CMS2MS2, a mitogenic protein isolated from Carica candamarcensis [0.03%]
Carica candamarcensis中分离得到的一种促有丝分裂蛋白CMS2MS2的结构
Marco Túlio R Gomes,Marcelo P Bemquerer,Miriam Tereza P Lopes et al.
Marco Túlio R Gomes et al.
In a recent study we showed that two proteinases (CMS2MS2 and CMS2MS3) from Carica candamarcensis enhance mammalian cell proliferation. The aim of the present study is the determination of the primary structure of CMS2MS2 and prediction of ...
The central domain of transcription factor FOXM1c directly interacts with itself in vivo and switches from an essential to an inhibitory domain depending on the FOXM1c binding site [0.03%]
转录因子FOXM1c的中央调控域在体内直接与其自身作用，并且根据结合位点的不同，既可以是正向调节又可以是负向调节该因子活性的作用区域
Inken Wierstra,Jürgen Alves
Inken Wierstra
We have previously shown that FOXM1c can transactivate its target genes by two different mechanisms, depending on the FOXM1c binding site. In the present study, by introducing a small 46-aa deletion, we confirm that the central domain of FO...
Chemical chaperone-mediated protein folding: stabilization of P22 tailspike folding intermediates by glycerol [0.03%]
化学助剂介导的蛋白质折叠：甘油稳定P22尾纤折叠中间体的作用
Rajesh Mishra,Rajiv Bhat,Robert Seckler
Rajesh Mishra
Polyol co-solvents such as glycerol increase the thermal stability of proteins. This has been explained by preferential hydration favoring the more compact native over the denatured state. Although polyols are also expected to favor aggrega...
Maria Teresa Sanna,Barbara Manconi,Gabriella Podda et al.
Maria Teresa Sanna et al.
The hemoglobin (Hb) substitution His-->Gln at position alpha89, very common in avian Hbs, is considered to be responsible for the weak Bohr effect of avian Hbs. Phoenicopterus ruber ruber is one of the few avian Hbs that possesses His at al...
Kristian H Link,Lixia Guo,Tyler D Ames et al.
Kristian H Link et al.
Full-length hammerhead ribozymes were subjected to in vitro selection to identify variants that are allosterically regulated by theophylline in the presence of a physiologically relevant concentration of Mg(2+). The population of allosteric...
Effect of bleomycin and cisplatin on the expression profile of SRA1, a novel member of pre-mRNA splicing factors, in HL-60 human promyelocytic leukemia cells [0.03%]
博莱霉素和顺铂对SRA1（一种新的剪接因子成员）在HL-60人类早幼粒白血病细胞表达谱的影响研究
Maria E Katsarou,Hellinida Thomadaki,Nikos Katsaros et al.
Maria E Katsarou et al.
Recently, a new member of the human SR (Ser/Arg-rich) superfamily of pre-mRNA splicing factors, SRA1 (SR-A1), has been discovered and cloned by members of our group, the gene for which was found to be overexpessed in a series of human tumor...
Anna Stengel,Jürgen Soll,Bettina Bölter
Anna Stengel
Protein import into plant chloroplasts is a fascinating topic that is being investigated by many research groups. Since the majority of chloroplast proteins are synthesised as precursor proteins in the cytosol, they have to be posttranslati...
Could the effect of modeled microgravity on osteogenic differentiation of human mesenchymal stem cells be reversed by regulation of signaling pathways? [0.03%]
调控信号通路能否逆转模拟微重力对人骨髓间充质干细胞向成骨细胞分化的影响？
Qiang Zheng,Guoping Huang,Jinfeng Yang et al.
Qiang Zheng et al.
Microgravity (MG) results in a reduction in bone formation. Bone formation involves osteogenic differentiation from mesenchymal stem cells (hMSCs) in bone marrow. We modeled MG to determine its effects on osteogenesis of hMSCs and used acti...
Plasminogen-dependent internalization of soluble melanotransferrin involves the low-density lipoprotein receptor-related protein and annexin II [0.03%]
依赖纤溶酶原的可溶性黑素转铁蛋白内吞作用涉及低密度脂蛋白受体相关蛋白和钙调神经磷酸酶B抑制蛋白亚基II的作用
Jonathan Michaud-Levesque,Michel Demeule,Richard Béliveau
Jonathan Michaud-Levesque
We investigated the effect of plasminogen (Plg) on the internalization of recombinant soluble melanotransferrin (sMTf) using U87 human glioblastoma cells and murine embryonic fibroblasts (MEF) deficient in the low-density lipoprotein recept...
Stefan Pieper,Stéphanie Vauléon,Sabine Müller
Stefan Pieper
Reversible chemistry, allowing for chain-forming as well as chain-breaking steps, is important for biological self-organization. In this context, ribozymes, catalyzing both RNA cleavage and ligation, may have significantly contributed to ex...