Marko Mihelic,Dusan Turk
Marko Mihelic
Thyroglobulin type-1 repeats are primarily found in thyroglobulin and several other functionally unrelated proteins. Because a few of them exhibit inhibitory activity against cysteine proteases they were named thyropins (thyroglobulin type-...
Proteinase inhibitors and biological control: an attractive international symposia series [0.03%]
蛋白酶抑制剂和生物防治国际研讨会集锦
Hans Fritz
Hans Fritz
Glucocorticoid receptor-mediated expression of kallikrein 10 in human breast cancer cell lines [0.03%]
人乳腺癌细胞系中由糖皮质激素受体介导的激肽原酶10表达
Vathany Kulasingam,Eleftherios P Diamandis
Vathany Kulasingam
Using the breast cell lines MCF-10A, MDA-MB-468 and T-47D, we investigated the role of various glucocorticoids in regulating human kallikrein 10 expression. We found that increased concentrations of glucocorticoids decreased KLK10 expressio...
An essential role for Pin1 in Xenopus laevis embryonic development revealed by specific inhibitors [0.03%]
组蛋白去乙酰化酶抑制剂联合Pin1特异性抑制剂揭示Pin1在非洲爪蟾早期胚胎发育中的重要功能
Dirk Wildemann,Birte Hernandez Alvarez,Gerlind Stoller et al.
Dirk Wildemann et al.
The peptidyl prolyl cis/trans isomerase (PPIase) Pin1 plays an important role in phosphorylation-dependent events of the cell cycle. This function is linked to its display of two phosphothreonine/phosphoserine-proline binding motifs, one wi...
Influence of pH and flanking serine on the redox potential of S-S and S-Se bridges of Cys-Cys and Cys-Sec peptides [0.03%]
pH及半胱氨酸周围丝氨酸对二硫化物和硒硫化物氧化还原电位的影响：二硫化物与硒硫化物桥肽的研究
Alex Schneider,Wolfgang Brandt,Ludger A Wessjohann
Alex Schneider
In selenocysteine (Sec, U)-containing proteins the selenenylsulfide bridge and its reduced thiol-selenol counterpart are usually the significant species. An important role for serine as flanking amino acid in the redox potential of S-S and ...
Effect of selenium on thioredoxin reductase activity in Txnrd1 or Txnrd2 hemizygous mice [0.03%]
硒对Txnrd1或Txnrd2单倍体小鼠中硫氧还蛋白还原酶活性的影响
Claudia Kiermayer,Bernhard Michalke,Jörg Schmidt et al.
Claudia Kiermayer et al.
Thioredoxin reductase 1 (Txnrd1) and thioredoxin reductase 2 (Txnrd2) are selenoproteins whose expression and function depends on adequate supply of the trace element selenium (Se). As homozygous (-/-) knockout of both Txnrd1 and Txnrd2 is ...
B- and T-cell-specific inactivation of thioredoxin reductase 2 does not impair lymphocyte development and maintenance [0.03%]
特异性失活B和T细胞中的硫氧还蛋白还原酶2不影响淋巴细胞的发育和维持
Roland Geisberger,Claudia Kiermayer,Cornelia Hömig et al.
Roland Geisberger et al.
Thioredoxin reductases (Txnrds) are a group of selenoenzymes participating in cellular redox regulation. Three Txnrd isoforms are known, each of which exhibits distinct cellular localisation and tissue-specific expression pattern. Txnrd1 is...
Glutathione- and thioredoxin-related enzymes are modulated by sulfur-containing chemopreventive agents [0.03%]
含硫化学预防剂调节谷胱甘肽和硫氧还蛋白相关酶的作用
Ying Hu,Sabine Urig,Sasa Koncarevic et al.
Ying Hu et al.
We studied the effects of sulfur-containing chemopreventive agents, including allyl sulfides and isothiocyanates, on human redox networks. Isothiocyanates inhibited isolated redox-active enzymes in a time- and dose-dependent manner. As show...
Towards understanding selenocysteine incorporation into bacterial proteins [0.03%]
论硒代半胱氨酸在细菌蛋白质中的嵌入机制
Niels Fischer,Alena Paleskava,Kirill B Gromadski et al.
Niels Fischer et al.
In bacteria, UGA stop codons can be recoded to direct the incorporation of selenocysteine into proteins on the ribosome. Recoding requires a selenocysteine incorporation sequence (SECIS) downstream of the UGA codon, a specialized translatio...
Selenoproteins of the thyroid gland: expression, localization and possible function of glutathione peroxidase 3 [0.03%]
甲状腺的硒蛋白：谷胱甘肽过氧化物酶3的表达、定位及可能的功能
Cornelia Schmutzler,Birgit Mentrup,Lutz Schomburg et al.
Cornelia Schmutzler et al.
The thyroid gland has an exceptionally high selenium content, even during selenium deficiency. At least 11 selenoproteins are expressed, which may be involved in the protection of the gland against the high amounts of H2O2 produced during t...