Characterisation of zinc-binding domains of peroxisomal RING finger proteins using size exclusion chromatography/inductively coupled plasma-mass spectrometry [0.03%]
使用尺寸排除层析/电感耦合等离子体质谱法表征过氧化物酶体C3HC4型锌指蛋白的结合域
Gunda Koellensperger,Simon Daubert,Ralf Erdmann et al.
Gunda Koellensperger et al.
We determined the zinc binding stoichiometry of peroxisomal RING finger proteins by measuring sulfur/metal ratios using inductively coupled plasma-mass spectrometry coupled to size exclusion chromatography, a strategy that provides a fast a...
Differential methylation kinetics of individual target site strands by T4Dam DNA methyltransferase [0.03%]
T4Dam DNA甲基转移酶作用于目标位点单链的甲基化动力学差异分析
Victor V Zinoviev,Alexey A Evdokimov,Ernst G Malygin et al.
Victor V Zinoviev et al.
Prokaryote DNA methyltransferases (MTases) of the Dam family (including those of bacteriophages T2 and T4) catalyze methyl group transfer from S-adenosyl-L-methionine (AdoMet), producing S-adenosyl-L-homocysteine (AdoHcy) and methylated ade...
Cellular localization of MAGI-1 caspase cleavage products and their role in apoptosis [0.03%]
MAGI-1切割产物的细胞定位及其在凋亡中的作用
Saska Ivanova,Urska Repnik,Lawrence Banks et al.
Saska Ivanova et al.
MAGI-1 is a membrane-associated guanylate kinase (MAGUK) protein present at adherent and tight junctions, where it acts as a structural and signaling scaffold. During apoptosis, MAGI-1 is cleaved by caspases at Asp761 into N- and C-terminal...
Characterization and comparative 3D modeling of CmPI-II, a novel 'non-classical' Kazal-type inhibitor from the marine snail Cenchritis muricatus (Mollusca) [0.03%]
来源于海洋螺类宝角曼氏锥螺(Cenchritis muricatus)(软体动物门)的新型“非经典”Kazal型蛋白酶抑制剂CmPI-II的特性及三维结构比较模拟研究
Yamile González,Tirso Pons,Jeovanis Gil et al.
Yamile González et al.
The complete amino acid sequence obtained by electrospray ionization tandem mass spectrometry of the proteinase inhibitor CmPI-II isolated from Cenchritis muricatus is described. CmPI-II is a 5480-Da protein with three disulfide bridges tha...
Association of cathepsin E with tumor growth arrest through angiogenesis inhibition and enhanced immune responses [0.03%]
天冬氨酸蛋白酶E通过抑制血管生成和增强免疫反应来阻止肿瘤生长
Masashi Shin,Tomoko Kadowaki,Jun-Ichi Iwata et al.
Masashi Shin et al.
Cathepsin E (CE) is an intracellular aspartic proteinase implicated in various physiological and pathological processes, yet its actual roles in vivo remain elusive. To assess the physiological significance of CE expression in tumor cells, ...
Human and mouse homo-oligomeric meprin A metalloendopeptidase: substrate and inhibitor specificities [0.03%]
人和小鼠同源寡聚体meprin A金属内肽酶：底物和抑制剂特异性
John E Bylander,Greg P Bertenshaw,Gail L Matters et al.
John E Bylander et al.
Meprin metalloproteinases have been implicated in the susceptibility to and progression of diabetic nephropathy and inflammatory bowel diseases. Our studies with experimental models of these diseases in mice are congruent with the conclusio...
Ulrich auf dem Keller,Alain Doucet,Christopher M Overall
Ulrich auf dem Keller
Proteases are specific modulators of signaling molecules and their underlying pathways in addition to their degradative roles. However, proteases do not act alone, but form cascades, circuits and networks that all dynamically interconnect t...
'Species' of peptidases [0.03%]
肽酶的种类
Alan J Barrett,Neil D Rawlings
Alan J Barrett
A good system for the naming and classification of peptidases can contribute much to the study of these enzymes. Having already described the building of families and clans in the MEROPS system, we here focus on the lowest level in the hier...
Cysteine proteases: destruction ability versus immunomodulation capacity in immune cells [0.03%]
半胱氨酸蛋白酶：在免疫细胞中破坏能力与免疫调节作用之间的权衡取舍
Tina Zavasnik-Bergant,Boris Turk
Tina Zavasnik-Bergant
Cysteine proteases (cathepsins) play a pivotal role in various physiological processes, as well as in several diseases. In the immune response, maturation of major histocompatibility class II (MHC II) molecules and processing of antigens fo...
Cysteine cathepsin non-inhibitory binding partners: modulating intracellular trafficking and function [0.03%]
半胱天冬氨酸酶非抑制性结合蛋白：调节细胞内运输和功能
Bernadette C Victor,Bonnie F Sloane
Bernadette C Victor
Cysteine cathepsins play a fundamental role in tumor growth, invasion and migration, angiogenesis, and the metastatic cascade. Evidence of their overexpression in a wide array of human tumors has been well documented. Cysteine cathepsins se...