Karen Hänel,Dieter Willbold
Karen Hänel
The SARS-CoV accessory protein 7a is a type I membrane protein with an extracellular domain of 81 amino acid residues. It is described to be expressed during infection and to be a component of the virus particle surface. In this study, we d...
Lumazine proteins from photobacteria: localization of the single ligand binding site to the N-terminal domain [0.03%]
发光细菌的卢马津蛋白：将单一配体结合位点定位到N端结构域
Boris Illarionov,Wolfgang Eisenreich,Martina Wirth et al.
Boris Illarionov et al.
Lumazine protein is believed to serve as an optical transponder in bioluminescence emission by certain marine bacteria. Sequence arguments suggest that the protein comprises two similarly folded riboflavin synthase-type domains, but earlier...
Novel zinc-responsive post-transcriptional mechanisms reciprocally regulate expression of the mouse Slc39a4 and Slc39a5 zinc transporters (Zip4 and Zip5) [0.03%]
新型锌响应的产后转录机制调节小鼠锌转运蛋白(Slc39a4和Slc39a5)的表达(Zip4和Zip5)
Benjamin P Weaver,Jodi Dufner-Beattie,Taiho Kambe et al.
Benjamin P Weaver et al.
Dietary zinc deficiency in mice is accompanied by enhanced expression of the zinc uptake transporter Slc39a4 (Zip4) and repressed expression of Slc39a5 (Zip5) in tissues which regulate zinc homeostasis (intestine, pancreas and visceral yolk...
A semi-rational design strategy of directed evolution combined with chemical synthesis of DNA sequences [0.03%]
基于化学合成的DNA序列的定向进化半理性设计策略
Ai-Sheng Xiong,Ri-He Peng,Jing Zhuang et al.
Ai-Sheng Xiong et al.
Directed evolution in vitro is a powerful molecular tool for the creation of new biological phenotypes. It is unclear whether it is more efficient to mutate an enzyme randomly or to mutate just the active sites or key sites. In this study, ...
Salivary agglutinin/glycoprotein-340/DMBT1: a single molecule with variable composition and with different functions in infection, inflammation and cancer [0.03%]
唾液聚集素/糖蛋白-340/DMBT1：一个具有可变组成并且在感染，炎症和癌症中具不同功能的单分子
Antoon J M Ligtenberg,Enno C I Veerman,Arie V Nieuw Amerongen et al.
Antoon J M Ligtenberg et al.
Salivary agglutinin (SAG), lung glycoprotein-340 (gp-340) and Deleted in Malignant Brain Tumours 1 (DMBT1) are three names for identical proteins encoded by the dmbt1 gene. DMBT1/SAG/gp-340 belongs to the scavenger receptor cysteine-rich (S...
Inken Wierstra,Jürgen Alves
Inken Wierstra
FOXM1 is a typical proliferation-associated transcription factor: it stimulates proliferation by promoting S-phase entry as well as M-phase entry and is involved in proper execution of mitosis. Accordingly, FOXM1 regulates genes that contro...
Activity of ulilysin, an archaeal PAPP-A-related gelatinase and IGFBP protease [0.03%]
一种古细菌型PAPP-A相关凝胶酶和IGFBP酶的活性研究
Cynthia Tallant,Raquel García-Castellanos,Aniebrys Marrero et al.
Cynthia Tallant et al.
Human growth and development are conditioned by insulin-like growth factors (IGFs), which have also implications in pathology. Most IGF molecules are sequestered by IGF-binding proteins (IGFBPs) so that exertion of IGF activity requires dis...
Novel expression of kallikreins, kallikrein-related peptidases and kinin receptors in human pleural mesothelioma [0.03%]
人胸膜间皮瘤中激肽释放酶、激肽释放酶相关肽酶和激肽受体的新型表达
Jessica Chee,Jasmine Singh,Anupam Naran et al.
Jessica Chee et al.
Malignant mesothelioma is an aggressive cancer of the pleura that is causally related to exposure to asbestos fibres. The kallikrein serine proteases [tissue (hK1) and plasma (hKB1) kallikreins, and kallikrein-related peptidases (KRP/hK2-15...
Martin Roderfeld,Jürgen Graf,Bernd Giese et al.
Martin Roderfeld et al.
Expression patterns of matrix metalloproteinase-9 (MMP-9) and its specific inhibitor, tissue inhibitor of metalloproteinases-1 (TIMP-1), are closely correlated with physiological and pathological processes characterized by the degradation a...
Defining the extended substrate specificity of kallikrein 1-related peptidases [0.03%]
界定相关肽酶的扩展底物特异性
Carla A Borgoño,Julie-Ann Gavigan,Juliano Alves et al.
Carla A Borgoño et al.
Human kallikrein 1-related peptidases (KLKs) form a subfamily of 15 extracellular (chymo)tryptic-like serine proteases. KLKs 4, 5, 13 and 14 display altered expression/activity in diverse pathological conditions, including cancer. However, ...