Oct4 expression revisited: potential pitfalls for data misinterpretation in stem cell research [0.03%]
Stefanie Liedtke,Milaid Stephan,Gesine Kögler
Stefanie Liedtke
The octamer-binding transcription factor 4 gene encodes a nuclear protein (Oct4, also known as Pou5F1 and Oct3/4) that belongs to a family of transcription factors containing the POU DNA-binding domain. Expression can be detected in embryon...
Alicia Rovó,Alois Gratwohl
Alicia Rovó
The postulated almost unlimited potential of transplanted hematopoietic stem cells (HSCs) to transdifferentiate into cell types that do not belong to the hematopoietic system denotes a complete paradigm shift of the hierarchical hemopoietic...
Munekazu Yamakuchi,Clare Bao,Marcella Ferlito et al.
Munekazu Yamakuchi et al.
Consumption of green tea is associated with a decrease in cardiovascular mortality. The beneficial health effects of green tea are attributed in part to polyphenols, organic compounds found in tea that lower blood pressure, reduce body fat,...
Kristian Schweimer,Arnd Petersen,Roland Suck et al.
Kristian Schweimer et al.
The major 97-aa timothy grass (Phleum pratense) allergen Phl p 3 was recently isolated from an extract of timothy grass pollen. Sequence comparison classifies this protein as a group 3 allergen. The solution structure of Phl p 3 as determin...
Bone marrow-derived mesenchymal stem cell transplantation does not improve quality of muscle reinnervation or recovery of motor function after facial nerve transection in rats [0.03%]
Maria Grosheva,Orlando Guntinas-Lichius,Stephan Arnhold et al.
Maria Grosheva et al.
Recently, we devised and validated a novel strategy in rats to improve the outcome of facial nerve reconstruction by daily manual stimulation of the target muscles. The treatment resulted in full recovery of facial movements (whisking), whi...
Tobias Cantz,Martina Bleidissel,Martin Stehling et al.
Tobias Cantz et al.
Recently, a new approach to reprogram somatic cells into pluripotent stem cells was shown by fusion of somatic cells with embryonic stem (ES) cells, which results in a tetraploid karyotype. Normal hepatocytes are often polyploid, so we deci...
Mihail Hristov,Alma Zernecke,Andreas Schober et al.
Mihail Hristov et al.
The mobilization and recruitment of bone marrow-derived, circulating or tissue resident progenitor cells giving rise to smooth muscle-like cells have been implicated in neointima hyperplasia after arterial injury and in accelerated forms of...
George M Yousef
George M Yousef
microRNAs (miRNAs) are a recently discovered class of small non-coding RNAs that regulate gene expression. Rapidly accumulating evidence has revealed that miRNAs are associated with cancer. The human tissue kallikrein gene family is the lar...
An AKT activity threshold regulates androgen-dependent and androgen-independent PSA expression in prostate cancer cell lines [0.03%]
Miltiadis Paliouras,Eleftherios P Diamandis
Miltiadis Paliouras
The androgen receptor (AR) plays an important role in early prostate cancer by activating transcription of a number of genes participating in cell proliferation and growth and cancer progression. However, as the cancer progresses, prostate ...
Genetic deficiency in tissue kallikrein activity in mouse and man: effect on arteries, heart and kidney [0.03%]
Anne Pizard,Christine Richer,Nadine Bouby et al.
Anne Pizard et al.
Tissue kallikrein (KLK1) is a kinin-forming serine protease synthesized in many organs including arteries and kidney. Study of the physiological role of KLK1 has benefited from the availability of mouse and human genetic models of KLK1 defi...