The 2nd International Symposium on Kallikreins and Kallikrein-Related Peptidases (ISK 2007) and the Commemorative Gold Medal of the E.K. Frey-E. Werle Foundation of the Henning L. Voigt Family [0.03%]
Maroulio Litsa Talieri
Maroulio Litsa Talieri
Hans Fritz
Hans Fritz
Cytokine combinations differentially influence the SDF-1alpha-dependent migratory activity of cultivated murine hematopoietic stem and progenitor cells [0.03%]
Susannah H Kassmer,Bernd Niggemann,Michael Punzel et al.
Susannah H Kassmer et al.
Stromal cell-derived factor-1alpha (SDF-1alpha) is a strong migratory stimulant for hematopoietic stem and progenitor cells (HSPCs). The hematopoietic cytokines thrombopoietin (TPO), Flt3-ligand (FL), stem cell factor (SCF) and interleukin ...
Koushik Chakrabarty,Rolf Heumann
Koushik Chakrabarty
The Ras signaling pathway plays a predominant role during development and controls diverse biological process in all eukaryotic cells. It is a member of the large family of GTPases proteins that binds and hydrolyzes GTP. Ras is a lipid-anch...
Bernd Giebel,Michael Punzel
Bernd Giebel
Hematopoietic stem cells have the potential to develop into multipotent and different lineage-restricted progenitor cells that subsequently generate all mature blood cell types. The classical model of hematopoietic lineage commitment propos...
A hypoallergenic hybrid molecule with increased immunogenicity consisting of derivatives of the major grass pollen allergens, Phl p 2 and Phl p 6 [0.03%]
Birgit Linhart,Nadine Mothes-Luksch,Susanne Vrtala et al.
Birgit Linhart et al.
Allergen-specific immunotherapy is currently based on the administration of allergen extracts containing natural allergens. However, its broad application is limited by the poor quality of these extracts. Based on recombinant allergens, wel...
Ibrahim Alkatout,Dieter Kabelitz,Holger Kalthoff et al.
Ibrahim Alkatout et al.
The importance of a subset of cells which have 'stem like' characteristics and are capable of tumor initiation has been reported for a range of tumors. Isolation of these tumor-initiating cells (TICs) has largely been based on differential ...
Jaroslav Matousek,Lidmila Orctová,Josef Skopek et al.
Jaroslav Matousek et al.
Hop latent viroid (HLVd) is not transmissible through hop generative tissues and seeds. Here we describe the process of HLVd elimination during development of hop pollen. HLVd propagates in uninucleate hop pollen, but is eliminated at stage...
Reconstitution of human azurocidin catalytic triad and proteolytic activity by site-directed mutagenesis [0.03%]
Mariusz Olczak,Katarzyna Indyk,Teresa Olczak
Mariusz Olczak
Azurocidin belongs to the serprocidin family, but it is devoid of proteolytic activity due to a substitution of His and Ser residues in the catalytic triad. The aim of this study was to reconstitute the active site of azurocidin by site-dir...
Dimerization of endogenous MT1-MMP is a regulatory step in the activation of the 72-kDa gelatinase MMP-2 on fibroblasts and fibrosarcoma cells [0.03%]
Signe Ingvarsen,Daniel H Madsen,Thore Hillig et al.
Signe Ingvarsen et al.
The secreted gelatinase matrix metalloprotease-2 (MMP-2) and the membrane-anchored matrix metalloprotease MT1-MMP (MMP-14), are central players in pericellular proteolysis in extracellular matrix degradation. In addition to possessing a dir...