The role of glycosylation and domain interactions in the thermal stability of human angiotensin-converting enzyme [0.03%]
糖基化和结构域相互作用对人肾素血管紧张素转化酶热稳定性的调节作用
Hester G O&#x;Neill,Pierre Redelinghuys,Sylva L U Schwager et al.
Hester G O&#x;Neill et al.
The N and C domains of somatic angiotensin-converting enzyme (sACE) differ in terms of their substrate specificity, inhibitor profiling, chloride dependency and thermal stability. The C domain is thermally less stable than sACE or the N dom...
Some assembly required: dedicated chaperones in eukaryotic proteasome biogenesis [0.03%]
分工合作：酵母蛋白酶体生物合成中的专职分子伴侣
Andrew R Kusmierczyk,Mark Hochstrasser
Andrew R Kusmierczyk
The 26S proteasome is the key eukaryotic protease responsible for the degradation of intracellular proteins. Protein degradation by the 26S proteasome plays important roles in numerous cellular processes, including the cell cycle, different...
Trial of the cysteine cathepsin inhibitor JPM-OEt on early and advanced mammary cancer stages in the MMTV-PyMT-transgenic mouse model [0.03%]
用于早期和晚期乳腺癌阶段的半胱氨酸天冬氨酰基蛋氨酰肽酶抑制剂JPM-OEt在MMTV-PyMT转基因小鼠模型中的试验研究
Uta Schurigt,Lisa Sevenich,Corinne Vannier et al.
Uta Schurigt et al.
Recent data suggest proteases of the papain-like cysteine cathepsin family as molecular targets for cancer therapy. Here, we report the treatment of polyoma middle T oncogene-induced breast cancers in mice with the cell-permeable broad-spec...
Human monocytes augment invasiveness and proteolytic activity of inflammatory breast cancer [0.03%]
人单核细胞增强炎性乳腺癌的侵袭性和蛋白水解活性
Mona Mostafa Mohamed,Dora Cavallo-Medved,Bonnie F Sloane
Mona Mostafa Mohamed
Inflammatory breast cancer (IBC) is the most aggressive form of breast cancer, and here, we examined in vitro the interactions between the human IBC cell line SUM149 and U937 human naive monocytes. We found an altered morphology, enhanced i...
Kai Melchior,Jonathan Weiss,Holm Zaehres et al.
Kai Melchior et al.
A number of recent studies identified nuclear factors that together have the unique ability to induce pluripotency in differentiated cell types. However, little is known about the factors that are needed to maintain human embryonic stem (ES...
Meta-Analysis
Biological chemistry. 2008 Jul;389(7):897-903. DOI:10.1515/BC.2008.108 2008
Manal Bosnali,Frank Edenhofer
Manal Bosnali
The transcription factors Oct4 and Sox2 are two of the main regulators of pluripotency in embryonic stem cells. Since the importance of non-genetic modification is continually increasing, particularly for therapeutic application of manipula...
Hans R Schöler
Hans R Schöler
Markus Müschen
Markus Müschen
Hannu Koistinen,Ale Närvänen,Miikka Pakkala et al.
Hannu Koistinen et al.
The prostate produces several proteases, the most abundant ones being kallikrein-related peptidase 3 (KLK3, PSA) and KLK2 (hK2), which are potential targets for tumor imaging and treatment. KLK3 expression is lower in malignant than in norm...
Mekdes Debela,Nathalie Beaufort,Viktor Magdolen et al.
Mekdes Debela et al.
Human kallikrein-related peptidases (KLKs) are (chymo)-trypsin-like serine proteinases that are expressed in a variety of tissues such as prostate, ovary, breast, testis, brain, and skin. Although their physiological functions have been onl...