Claudia Haller,Oliver T Fackler
Claudia Haller
Cell-cell transmission of human immunodeficiency virus type 1 (HIV-1) is considered the most effective mode of viral spread in T-lymphocyte cultures. Evidence has accumulated that HIV-1 assembles polarized synaptic-like structures, referred...
Fast in vitro translation system immobilized on a surface via specific biotinylation of the ribosome [0.03%]
通过核糖体的特异性生物素化将体外快速翻译系统固定在表面
Romualdas Stapulionis,Yuhong Wang,Graham T Dempsey et al.
Romualdas Stapulionis et al.
The ribosome is the macromolecular machine responsible for translating the genetic code into polypeptide chains. Despite impressive structural and kinetic studies of the translation process, a number of challenges remain with respect to und...
Mechanism of methaemoglobin breakdown by the lysine-specific gingipain of the periodontal pathogen Porphyromonas gingivalis [0.03%]
牙龈卟啉单胞菌赖氨特异型gingipain降解正铁血红蛋白的机制研究
John W Smalley,Andrew J Birss,Borys Szmigielski et al.
John W Smalley et al.
Abstract The R- and K-gingipain proteases of Porphyromonas gingivalis are involved in proteolysis of haemoglobin from which the defensive dimeric haem pigment is formed. Whilst oxyhaemoglobin is refractory towards K-gingipain, methaemoglobi...
Expression of tissue and plasma kallikreins and kinin B1 and B2 receptors in lung cancer [0.03%]
肺癌中组织和血浆激肽酶及激肽B1和B2受体的表达
Jessica Chee,Anupam Naran,Neil L Misso et al.
Jessica Chee et al.
Tissue kallikrein (hK1) and plasma kallikrein (PK, hKB1) are serine proteases that produce biologically active kinin peptides from endogenous kininogen substrates. There is evidence linking the kallikreins and the mitogenic kinin peptides t...
Stanley M Belkowski,John Masucci,Andrew Mahan et al.
Stanley M Belkowski et al.
Secretory leukocyte protease inhibitor (SLPI) is a protease inhibitor of the whey acidic protein-like family inhibiting chymase, chymotrypsin, elastase, proteinase 3, cathepsin G and tryptase. Performing in vitro enzymatic assays using both...
Putative identification of an amphipathic alpha-helical sequence in hemolysin of Escherichia coli (HlyA) involved in transmembrane pore formation [0.03%]
参与形成穿过细胞膜孔通道的两亲性α-螺旋序列的假定鉴定（来源于大肠杆菌的溶血素）
Angela Valeva,Isabel Siegel,Mark Wylenzek et al.
Angela Valeva et al.
Abstract Escherichia coli hemolysin is a pore-forming protein belonging to the RTX toxin family. Cysteine scanning mutagenesis was performed to characterize the putative pore-forming domain of the molecule. A single cysteine residue was int...
A common binding motif for various bacteria of the bacteria-binding peptide SRCRP2 of DMBT1/gp-340/salivary agglutinin [0.03%]
DMBT1/GP-340/唾液聚集素的细菌结合肽SRCRP2的共同配体基序：与多种细菌共有的结合模式
Jelani T D Leito,Antoon J M Ligtenberg,Kamran Nazmi et al.
Jelani T D Leito et al.
Abstract Salivary agglutinin (DMBT1SAG) is identical to lung glycoprotein-340 and encoded by deleted in malignant brain tumors-1. It is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, proteins that have one or more SRCR...
Molecular mechanisms of aromatase inhibition by new A, D-ring modified steroids [0.03%]
新型A环和D环修饰的类固醇芳香化酶抑制分子机制研究
Margarida Cepa,Georgina Correia-da-Silva,Elisiário J Tavares da Silva et al.
Margarida Cepa et al.
A recent approach for treatment and prevention of estrogen-dependent breast cancer focuses on the inhibition of aromatase, the enzyme that catalyzes the final step of estrogen biosynthesis. Some synthetic steroids, such as formestane and ex...
Docking of tryptophanyl [corrected tryptophan] analogs to trytophanyl-tRNA synthetase: implications for non-canonical amino acid incorporations [0.03%]
色氨酸类似物与色氨酰-tRNA合成酶的结合：非规范氨基酸掺入的意义
M Kamran Azim,Nediljko Budisa
M Kamran Azim
Non-canonical amino acids (NAA), as building blocks for peptides and proteins during ribosomal translation, represent a nearly infinite supply of novel functions. The specific selection, activation and tRNA-charging of amino acids by aminoa...
Fluoride complexes of oncogenic Ras mutants to study the Ras-RasGap interaction [0.03%]
致癌RAS突变体的氟化物复合物用于研究RAS-RASGap相互作用
Lothar Gremer,Bernd Gilsbach,Mohammad Reza Ahmadian et al.
Lothar Gremer et al.
Down-regulation of Ras signalling is mediated by specific GTPase-activating proteins (GAPs), which stimulate the very slow GTPase reaction of Ras by 10(5)-fold. The basic features of the GAP activity involve the stabilisation of both switch...