Cytotoxic and peptidase inhibitory activities of selected non-hepatotoxic cyclic peptides from cyanobacteria [0.03%]
具细胞毒和肽酶抑制活性的两种非肝毒类环形多肽
Anja Bubik,Bojan Sedmak,Marko Novinec et al.
Anja Bubik et al.
Toxic cyanobacterial blooms are a rich source of metabolites having a variety of biological activities. Two main groups of cyclic peptides, depsipeptides and ureido linkage-containing peptides, reportedly inhibit serine peptidases. We chara...
Effects of the Cdc2-like kinase-family and DNA topoisomerase I on the alternative splicing of eNOS in TNF-alpha-stimulated human endothelial cells [0.03%]
Cdc2样蛋白激酶族和DNA拓扑异构酶I对TNF-α刺激的人内皮细胞中eNOS选择性拼接的影响
Andreas Eisenreich,Ulrike Boltzen,Wolfgang Poller et al.
Andreas Eisenreich et al.
Nitric oxide (NO) is synthesized by endothelial nitric oxide synthase (eNOS) and plays an important role in vascular homeostasis and cardiovascular diseases. It has recently been shown that increased expression of alternatively spliced eNOS...
Impaired synthesis of heme oxygenase-1 in Fanconi anemia cells can be rescued by transfection of Fanconi wild-type cDNA [0.03%]
转染福尼氏贫血病野生型cDNA可以弥补福尼柯氏贫血细胞中血红素加氧酶-1合成的缺陷
Maria Kontou,Monica Hirsch-Kauffmann,Manfred Schweiger
Maria Kontou
Fanconi anemia is a fatal, hereditary chromosome instability syndrome of early childhood with progressive pancytopenia and cancer-proneness. Hypersensitivity to alkylating agents points to DNA repair inefficiency. Excess reactive oxygen int...
Torsten Waldminghaus,Jens Kortmann,Stefan Gesing et al.
Torsten Waldminghaus et al.
Structured RNAs with fundamental sensory and regulatory potential have been discovered in all kingdoms of life. Bacterial RNA thermometers are located in the 5'-untranslated region of certain heat shock and virulence genes. They regulate tr...
Specific inhibition of transcriptional activity of the constitutive androstane receptor (CAR) by the splicing factor SF3a3 [0.03%]
新型肝特异性RNA拼接因子SF3a3通过抑制构成型雄甾烷受体(CAR)转录活性发挥肝保护作用
Hye Jin Yun,Jungsun Kwon,Wongi Seol
Hye Jin Yun
The constitutive androstane receptor (CAR) is a member of the nuclear receptor superfamily and plays an important role in the degradation of xenobiotics in the liver. Using yeast two-hybrid screening, we identified SF3a3, a 60-kDa subunit o...
Influenza viruses and the NF-kappaB signaling pathway - towards a novel concept of antiviral therapy [0.03%]
流感病毒与NF-κB信号转导通路——寻找新的抗病毒治疗理念
Stephan Ludwig,Oliver Planz
Stephan Ludwig
Influenza A virus remains a major public health concern, both in its annual toll in death and debilitation and its potential to cause devastating pandemics. Like any other virus, influenza A viruses are strongly dependent on cellular factor...
Hepatitis C virus (HCV) employs multiple strategies to subvert the host innate antiviral response [0.03%]
丙型肝炎病毒(HCV)采用多种策略来逃避宿主的天然抗病毒反应
Johannes G Bode,Erwin D Brenndörfer,Dieter Häussinger
Johannes G Bode
Hepatitis C virus (HCV) is a serious global health problem which accounts for approximately 40% of chronic liver diseases worldwide. HCV frequently establishes a persistent infection, although it is recognized and targeted by innate immunit...
Thorsten Wolff,Florian Zielecki,Marion Abt et al.
Thorsten Wolff et al.
Vertebrate cells activate multiple signaling modules upon virus infection to eliminate the invading pathogen and to prevent the establishment of a persistent infection. A major immediate response pathway is controlled by the RNA helicases R...
RNA viruses and the mitogenic Raf/MEK/ERK signal transduction cascade [0.03%]
rna病毒与增殖性raf/mek/erk信号转导途径
Stephan Pleschka
Stephan Pleschka
The Raf/MEK/ERK signal transduction cascade belongs to the mitogen-activated protein kinase (MAPK) cascades. Raf/MEK/ERK signaling leads to stimulus-specific changes in gene expression, alterations in cell metabolism or induction of program...
Pursuing different 'TRADDes': TRADD signaling induced by TNF-receptor 1 and the Epstein-Barr virus oncoprotein LMP1 [0.03%]
不同模式的“TRADDe”诱导：TNF受体1和EB病毒致癌蛋白LMP1介导的TRADD信号转导
Arnd Kieser
Arnd Kieser
The pro-apoptotic tumor necrosis factor (TNF)-receptor 1-associated death domain protein (TRADD) was initially identified as the central signaling adapter molecule of TNF-receptor 1 (TNFR1). Upon stimulation with the pro-inflammatory cytoki...