Heike Grassmé,Katrin Anne Becker,Yang Zhang et al.
Heike Grassmé et al.
Ceramide is formed by the activity of sphingomyelinases, by degradation of complex sphingolipids, reverse ceramidase activity or de novo synthesized. The formation of ceramide within biological membranes results in the formation of large ce...
Molecular profile of breast versus ovarian cancer cells in response to treatment with the anticancer drugs cisplatin, carboplatin, doxorubicin, etoposide and taxol [0.03%]
顺铂、卡铂、多柔比星、依托泊苷和紫杉醇抗肿瘤药物对乳腺癌和卵巢癌细胞反应的分子特征 profiling
Hellinida Thomadaki,Andreas Scorilas
Hellinida Thomadaki
We assessed changes in the apoptosis-related genes BCL2, BAX, BCL2L12, FAS and CASPASE-3 in OVCAR-3 human ovarian cancer cells and BT-20 human breast cancer cells to provide an insight into the molecular mechanisms involved in the response ...
Sphingosine kinase 1 and 2 regulate the capacity of mesangial cells to resist apoptotic stimuli in an opposing manner [0.03%]
鞘氨醇激酶1和2以相反的方式调节系膜细胞抵抗凋亡刺激的能力
Lotte P Hofmann,Shuyu Ren,Stephanie Schwalm et al.
Lotte P Hofmann et al.
Abstract Sphingosine kinases (SKs) are key enzymes regulating the production of sphingosine-1-phosphate (S1P), which determines important cell responses including cell growth and death. Here we show that renal mesangial cells isolated from ...
Regulation of kinin B(2) receptors by bradykinin in human lung cells [0.03%]
缓激肽调节人肺细胞中激肽B(2)受体的功能研究
Sara H Bengtson,Jane Eddleston,Matthias Mörgelin et al.
Sara H Bengtson et al.
Bradykinin is a potent mediator of inflammation that has been shown to participate in allergic airway inflammation. The biologic effects of bradykinin are mediated by binding and activation of its cognate receptor, the B(2) receptor (B(2)R)...
Immunohistochemical evidence of ubiquitous distribution of the metalloendoprotease insulin-degrading enzyme (IDE; insulysin) in human non-malignant tissues and tumor cell lines [0.03%]
人非恶性组织和肿瘤细胞系中金属内肽酶胰岛素降解酶(IDE; insulysin)普遍分布的免疫组化证据
Gregor Weirich,Karin Mengele,Christina Yfanti et al.
Gregor Weirich et al.
Immunohistochemical evidence of ubiquitous distribution of the metalloprotease insulin-degrading enzyme (IDE; insulysin) in human non-malignant tissues and tumor cells is presented. Immunohistochemical staining was performed on a multi-orga...
Relevance of the amino acid conversions L144R (Zaragoza) and L159P (Zavalla) in the apolipoprotein A-I binding site for haptoglobin [0.03%]
氨基酸转换L144R（萨拉戈萨）和L159P（扎瓦拉）与血红蛋白结合位点的载脂蛋白A-I的相关性
Luisa Cigliano,Luca D D&#x;Andrea,Bernardetta Maresca et al.
Luisa Cigliano et al.
The high-density lipoprotein apolipoprotein A-I (ApoA-I) stimulates the enzyme lecithin-cholesterol acyltransferase (LCAT) in the reverse cholesterol transport pathway. Two ApoA-I variants, Zaragoza (L144R) and Zavalla (L159P), are associat...
Nitric oxide and sphingolipids: mechanisms of interaction and role in cellular pathophysiology [0.03%]
一氧化氮和鞘脂：相互作用机制及其在细胞病理生理中的作用
Cristiana Perrotta,Clara De Palma,Emilio Clementi
Cristiana Perrotta
Nitric oxide is a short-lived messenger with pleiotropic roles in the regulation of cell patho-physiological processes, including survival, death, proliferation and differentiation. Increasing evidence over the last few years has shown that...
Sylvia Neumann,Gerrit van Meer
Sylvia Neumann
The various membranes in eukaryotic cells have unique lipid compositions. Despite important discoveries in lipid research over recent decades, the basic principles by which cells define their membrane compositions are essentially unknown. C...
Bauhinia Kunitz-type proteinase inhibitors: structural characteristics and biological properties [0.03%]
Bauhinia 型克氏蛋白酶抑制剂的结构特征及生物活性
Maria Luiza Vilela Oliva,Uemura Misako Sampaio
Maria Luiza Vilela Oliva
Plant proteinase inhibitors are involved in the regulation of the activity of many proteinases and, in consequence, in biological processes driven by proteolysis. In this review, we summarize recent results on the activity of native Bauhini...
Georgia Sotiropoulou,Christian P Sommerhoff
Georgia Sotiropoulou