Reduction of myocardial infarction by postischemic administration of the calpain inhibitor A-705253 in comparison to the Na(+)/H(+) exchange inhibitor Cariporide in isolated perfused rabbit hearts [0.03%]
与氯吡格雷相比，心肌缺血再灌注损伤后应用A-705253对兔离体心脏的保护作用
Christiane Neuhof,Verena Fabiunk,Maria Speth et al.
Christiane Neuhof et al.
The calpain inhibitor A-705253 and the Na(+)/H(+)-exchange inhibitor Cariporide were studied in isolated perfused rabbit hearts subjected to 60 min occlusion of the ramus interventricularis of the left coronary artery (below the origin of t...
Role of tissue kallikrein-related peptidases in cervical mucus remodeling and host defense [0.03%]
组织相关肽酶在宫颈粘液重塑和宿主防御中的作用
Julie L V Shaw,Constantina Petraki,Carole Watson et al.
Julie L V Shaw et al.
Human tissue kallikrein-related peptidases (KLKs) are 15 hormonally regulated genes on chromosome 19q13.4 encoding secreted serine proteases. Many KLKs are expressed throughout the female reproductive system and found in cervico-vaginal flu...
T-SP1: a novel serine protease-like protein predominantly expressed in testis [0.03%]
T-SP1：一种新型的类似丝氨酸蛋白酶的蛋白质在睾丸中高表达
Peter Neth,Birgit Profanter,Claudia Geissler et al.
Peter Neth et al.
Here, we describe a novel member in the group of membrane-anchored chymotrypsin (S1)-like serine proteases, namely testis serine protease 1 (T-SP1), as it is principally expressed in testis tissue. The human T-SP1 gene encompasses 28.7 kb o...
N-terminal polyglutamine-containing fragments inhibit androgen receptor transactivation function [0.03%]
N端多聚谷氨酰胺片段抑制雄激素受体的转激活功能
Niclas W Schiffer,Jocelyn Céraline,F Ulrich Hartl et al.
Niclas W Schiffer et al.
Abstract Several neurodegenerative diseases, including Kennedy's disease (KD), are associated with misfolding and aggregation of polyglutamine (polyQ)-expansion proteins. KD is caused by a polyQ-expansion in the androgen receptor (AR), a ke...
Interaction of angiotensin-converting enzyme (ACE) with membrane-bound carboxypeptidase M (CPM) - a new function of ACE [0.03%]
血管紧张素转换酶(ACE)与膜结合羧肽酶M(CPM)的相互作用-ACE的新功能
Xiaoou Sun,Burkhard Wiesner,Dorothea Lorenz et al.
Xiaoou Sun et al.
Angiotensin-converting enzyme (ACE) demonstrates, besides its typical dipeptidyl-carboxypeptidase activity, several unusual functions. Here, we demonstrate with molecular, biochemical, and cellular techniques that the somatic wild-type muri...
An efficient fluorimetric method to measure the viability of intraerythrocytic Plasmodium falciparum [0.03%]
一种测量红细胞内恶性疟原虫存活性的高效荧光法
Astrid Evers,Saskia Heppner,Matthias Leippe et al.
Astrid Evers et al.
A range of various assays to measure chemosusceptibility of Plasmodium falciparum have been described in the literature. As the screening of a plethora of compounds for antiplasmodial activity is urgently needed and becomes a constantly inc...
S(1)' and S(2)' subsite specificities of human plasma kallikrein and tissue kallikrein 1 for the hydrolysis of peptides derived from the bradykinin domain of human kininogen [0.03%]
人血浆激肽原酶和组织激肽原酶1对人激肽原bradykinin区域衍生多肽的S(1) '和S(2) '亚位点特异性水解研究
Aurelio Resende Lima,Fabiana M Alves,Pedro Francisco Angelo et al.
Aurelio Resende Lima et al.
The S(1)' and S(2)' subsite specificities of human tissue kallikrein 1 (KLK1) and human plasma kallikrein (HPK) were examined with the peptide series Abz-GFSPFRXSRIQ-EDDnp and Abz-GFSPFRSXRIQ-EDDnp [X=natural amino acids or S(PO(3)H(2))]. K...
Homologous and heterologous expression and maturation processing of extracellular glutamyl endopeptidase of Staphylococcus epidermidis [0.03%]
表皮葡萄球菌细胞外谷氨酰内肽酶的同源与异源表达及其分泌后加工成熟研究
Yuko Ohara-Nemoto,Toshio Ono,Yu Shimoyama et al.
Yuko Ohara-Nemoto et al.
The extracellular serine endopeptidase GluSE (EC 3.4.21.19) is considered to be one of the virulence factors of Staphylococcus epidermidis. The present study investigated maturation processing of native GluSE and that heterologously express...
Acid beta-glucosidase: insights from structural analysis and relevance to Gaucher disease therapy [0.03%]
酸性β-葡萄糖苷酶：结构分析的新见解及其对于戈谢病治疗的意义
Yaacov Kacher,Boris Brumshtein,Swetlana Boldin-Adamsky et al.
Yaacov Kacher et al.
In mammalian cells, glucosylceramide (GlcCer), the simplest glycosphingolipid, is hydrolyzed by the lysosomal enzyme acid beta-glucosidase (GlcCerase). In the human metabolic disorder Gaucher disease, GlcCerase activity is significantly dec...