DNA extraction from long-term preserved formalin-fixed paraffin-embedded samples of thymic epithelial tumours - a performance comparison of three commercial kits [0.03%]
长期保存的甲醛固定石蜡包埋胸腺上皮肿瘤样本的DNA提取——三种商用试剂盒的效果比较
Duc Manh Le,Thi Xuan Nguyen,Thanh Chung Dang et al.
Duc Manh Le et al.
Introduction: Thymic epithelial tumours (TET) are a rare, histologically varied group of malignancies, classified by the World Health Organization into 5 subtypes ranging from indolent to aggressive forms. Formalin-fixed ...
Real-world outcomes of immune checkpoint inhibitor monotherapy in later lines of recurrent/metastatic cervical cancer - evidence from a rescue access program in Poland [0.03%]
波兰救援准入计划中免疫检查点抑制剂单药治疗复发/转移性宫颈癌患者的现实世界结果证据
Renata Pacholczak-Madej,Maja Lisik-Habib,Radosław Mądry et al.
Renata Pacholczak-Madej et al.
Introduction: Immune checkpoint inhibitors (ICIs) are a therapeutic option for recurrent/metastatic cervical cancer (r/mCC) following platinum-based chemotherapy. However, real-world data on their effectiveness and safety...
Cancer-associated thromboses in non-small cell lung cancer patients with epidermal growth factor receptor mutation [0.03%]
表皮生长因子受体突变非小细胞肺癌患者的癌栓形成并发症
Yosuke Maezawa,Manato Taguchi,Takeshi Kawakami et al.
Yosuke Maezawa et al.
Introduction: The purposes of this study were to clarify whether non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) gene mutation have a higher incidence of cancer-associated venous a...
First report of refractory grey zone lymphoma in an adolescent patient treated successfully with pembrolizumab [0.03%]
青少年难治性灰色区域淋巴瘤一例及成功应用派姆单抗治疗报告
Maria Dudzik,Anna Zaniewska-Tekieli,Walentyna Balwierz et al.
Maria Dudzik et al.
Grey zone lymphoma (GZL) is a rare and aggressive B-cell lymphoma, exhibiting features of both diffuse large B-cell lymphoma and classical Hodgkin's lymphoma (cHL). Due to its rarity, especially in paediatric patients, no standardized treat...
Athanasia Karavasili,Melina Yerolatsite,George Zarkavelis et al.
Athanasia Karavasili et al.
Immune checkpoint inhibitors (ICIs) have become a cornerstone in the treatment of various solid tumors due to their proven efficacy. However, their use is associated with immune-related adverse events (irAEs), which arise from the immune re...
High expression of the eukaryotic initiation factors eIF4a and eIF4e in retinoblastoma [0.03%]
视网膜母细胞瘤中存在大量的真核起始因子eIF4A和eIF4E
Nora Fischer,Antje Schinlauer,Piotr Czapiewski et al.
Nora Fischer et al.
Introduction: Retinoblastoma is a malignant, intraocular tumor which deve-lops within the first three years of life and has a variable prognosis. Aberrant expression of eukaryotic initiation factors (eIFs) has been report...
Interleukin-6 as the preferred prognostic factor in infection-complicated acute myeloid leukemia [0.03%]
interleukin-6作为感染合并急性髓系白血病预后的优选指标
Natalia Bujko-Wasiak,Aleksandra Kaźmierczak,Łukasz Dariusz Lisak et al.
Natalia Bujko-Wasiak et al.
Introduction: This study investigated the prognostic significance of interleukin-6 (IL-6) in predicting infection severity and mortality among patients with acute myeloid leukemia (AML). Given the high susceptibility of A...
Enhanced antitumour efficacy of ferulic acid nanoparticles in combination with doxorubicin - a promising strategy for breast cancer treatment [0.03%]
白杨素纳米粒联合阿霉素的协同抗肿瘤作用及机制研究
Alshimaa F Salama,Gamal A Omran,Ahmad M Salahuddin et al.
Alshimaa F Salama et al.
Introduction: The discovery of anti-cancer drugs from natural plants represents a large interest around the world. Ferulic acid (FA) is a natural phenolic acid has antitumor activity. Doxorubicin (DOX) is a potent chemoth...
Outcomes of extensive-stage small cell lung cancer treatment in a real-world clinical setting: a single-center experience [0.03%]
广泛期小细胞肺癌真实世界治疗结局及影响因素的单中心研究
Kresimir Tomic,Emir Begagic,Ema Voloder et al.
Kresimir Tomic et al.
Introduction: Small cell lung cancer (SCLC) is a highly aggressive subtype of lung cancer that accounts for approximately 15% of all lung cancers. Despite advancements in treatment, real-world clinical practice in develop...
LINE-1 retrotransposon activation drives age-associated inflammation via cytoplasmic cDNA-STING/type I interferon signalling: therapeutic potential of reverse transcriptase inhibition [0.03%]
线粒体DNA泄漏引发STING信号致年龄相关炎症的机制及治疗方法
Arshad Mehmood,Yue Zhu Xue,Habab Merghani Yassin et al.
Arshad Mehmood et al.
Retrotransposable elements are harmful at several levels, and host surveillance systems fail to consider all these elements in severe effects. The key role of retrotransposon in aging and age-associated diseases remains unclear. We summaris...