Sylwia Smolinska,Urszula Radzikowska,Marlena Tynecka et al.
Sylwia Smolinska et al.
Dexmedetomidine inhibits the Wnt/β-catenin pathway, regulates ferroptosis in bladder cancer cells and the tumor immune microenvironment, and suppresses tumorigenesis in a mouse bladder cancer model [0.03%]
右美托咪啶通过抑制Wnt/β-连环蛋白信号通路调节膀胱癌细胞的铁死亡及肿瘤免疫微环境并抑制小鼠膀胱肿瘤发生生长
Zhi Wang,Weina Bai
Zhi Wang
Introduction: This study aimed to explore the antitumor effects of dexmedetomidine (Dex) in bladder cancer, focusing on its role in modulating ferroptosis and the tumor immune microenvironment. ...
Paeoniflorin inhibits degranulation of mast cells through suppressing the cGAS/STING signaling pathway [0.03%]
芍药苷通过抑制cGAS-STING信号通路抑制肥大细胞脱颗粒反应
Guanli Song,Guanbo Song,Xiaji Zhou et al.
Guanli Song et al.
Introduction: Allergic rhinitis is an allergic disease that affects the nasal mucosa, and its incidence has been increasing significantly in recent years. Paeoniflorin (PF) is the main chemical component of total glucosid...
Glutaminase-mediated glutamate metabolism is critical for maintaining Th17/Treg balance [0.03%]
谷氨酰胺酶介导的谷氨酸代谢对维持Th17/Treg平衡至关重要
Xiaohan Jin,Jinglong Tao
Xiaohan Jin
Autoimmune diseases are severe disorders that affect populations worldwide. Their occurrence is considered to be multifactorial: genetic, hormonal and immunological factors all contribute to the development of autoimmune diseases. CD4 T cel...
p65 enhanced METTL3-mediated m6A methylation of HMGB1 to promote microglia M1 polarization in sepsis-associated encephalopathy [0.03%]
NF-κB p65通过增强METTL3介导的HMGB1 m6A甲基化促进脓毒症相关性脑病小胶质细胞M1型极化
Xiaowen Wu,Jie Wang,Jun Li et al.
Xiaowen Wu et al.
Introduction: Sepsis-associated encephalopathy (SAE) is a complication posing a significant risk to patient health and survival. Microglial polarization and inflammation are key to the pathological progression of SAE. The...
Intestinal CD8+ γδ T cells shift from immune activation to suppression, with concomitant impairment of cytotoxicity as disease activity increases in patients with ulcerative colitis [0.03%]
溃疡性结肠炎患者病程中肠道CD8+γδT细胞从免疫激活向抑制转变并伴随杀伤力的下降
Jia Zhu,Tao Zhu,Caixia Sheng et al.
Jia Zhu et al.
Introduction: Ulcerative colitis (UC) is a persistent inflammatory intestinal condition characterized by fluctuating disease activity (DA), with incompletely understood immunopathogenesis. ...
lncRNA FENDRR targets miR-3614-5p to promote sepsis-induced acute kidney injury via the pro-inflammatory response [0.03%]
长链非编码RNA FENDRR通过靶向miR-3614-5p促进脓毒症诱发的急性肾损伤中的促炎反应
Quanan He,Yiqing Li,Yanping Peng et al.
Quanan He et al.
Introduction: Acute kidney injury (AKI) raises mortality rates in septic patients. This study investigated the relationship between lncRNA FENDRR and miR-3614-5p, aiming to examine FENDRR's clinical significance in sepsis...
Lung macrophages in pulmonary homeostasis and disease: from basic biology to clinical applications [0.03%]
肺泡巨噬细胞在肺部稳态和疾病中的作用：从基础生物学研究到临床应用
Yule Zhang,Sujuan Sun,Jianlin Yang et al.
Yule Zhang et al.
Lung macrophages, as key components of the pulmonary immune system, exert multiple key functions in maintaining pulmonary homeostasis and immune defense by eliminating pathogens (such as bacteria and viruses), modulating inflammatory respon...
Linking IgE and mast cells in pediatric allergic multimorbidity: omalizumab as a therapeutic strategy for asthma and cow's milk allergy [0.03%]
IgE和肥大细胞在儿科过敏多发性疾病中的联系：奥马珠单抗作为治疗哮喘和牛奶过敏的策略
Peter Kunč,Jaroslav Fábry,Martina Neuschlová et al.
Peter Kunč et al.
This case report presents a 7-year-old boy with severe, early-onset cow's milk allergy (CMA) and poorly controlled, severe persistent asthma, highlighting the challenges of managing pediatric allergic multimorbidity. The patient experienced...
Karolina Cichoń-Kawa,Emilia Płatos,Wojciech Wasiak et al.
Karolina Cichoń-Kawa et al.
Immunoglobulin A (IgA) vasculitis (IgAV) is the most common form of vasculitis in the pediatric population. From 30% to 60% of children with IgAV are affected by the accumulation of deposits of IgA in the glomeruli and the development of ne...