Takashi Morita
Takashi Morita
The structural and functional studies of the first identified C-type lectin-like protein (CLP), blood coagulation factor IX/factor X-binding protein (IX/X-bp), have been instrumental in defining how new functionally heterodimeric CLPs are g...
Kenneth J Clemetson,Qiumin Lu,Jeannine M Clemetson
Kenneth J Clemetson
Snake venoms are complex mixtures of biologically active proteins and peptides. Many affect haemostasis by activating or inhibiting coagulant factors or platelets, or by disrupting endothelium. Snake venom components are classified into var...
Elena A Ermakova,Mikhail A Panteleev,Emmanuil E Shnol
Elena A Ermakova
This study analyses the effect of flow and boundary reactions on spatial propagation of waves of blood coagulation. A simple model of coagulation in plasma consisting of three differential reaction-diffusion equations was used for numerical...
A I Lobanov,T K Starozhilova
A I Lobanov
Two mathematical models of clot growth in the fluid flows have been considered. The first one is the model of embolus growth in a wall-adjacent flow. The effect of hydrodynamic flows on proceeding chemical reactions and the backward effect ...
M Anand,K Rajagopal,K R Rajagopal
M Anand
Both biochemical and mechanical factors have to be taken into account if a meaningful model for the formation, growth, and lysis of clots in flowing blood is to be developed. Most models that are currently in use neglect one or the other of...
Coagulation under flow: the influence of flow-mediated transport on the initiation and inhibition of coagulation [0.03%]
流动条件下的凝血：流动介导输运对凝血启动和抑制的影响
Aaron L Fogelson,Nessy Tania
Aaron L Fogelson
A mathematical model of intravascular coagulation is presented; it encompasses the biochemistry of the tissue factor pathway, platelet activation and deposition on the subendothelium, and flow- and diffusion-mediated transport of coagulatio...
Ken Lo,William S Denney,Scott L Diamond
Ken Lo
A kinetic Monte Carlo simulation was developed using the deterministic reaction network developed by the Mann laboratory for tissue-factor (TF)-initiated blood coagulation. The model predicted thrombin dynamics in recalcified whole blood (3...
Demonstration of a threshold response in a proteolytic feedback system: control of the autoactivation of factor XII [0.03%]
丝氨酸蛋白酶活化反馈系统中产生阈值响应的演示：因子Ⅻ自活化的调控
Jolyon Jesty,José Rodriguez,Edward Beltrami
Jolyon Jesty
Mathematical analysis of positive feedback loops in proteolytic systems has previously suggested that when the active enzymes are subject to inhibitory control these systems will exhibit threshold behavior. This is demonstrated in the prese...
Fazoil I Ataullakhanov,Mikhail A Panteleev
Fazoil I Ataullakhanov
Over the last two decades, mathematical modeling has become a popular tool in study of blood coagulation. The in silico methods were able to yield interesting and significant results in the understanding of both individual reaction mechanis...
Towards virtual coagulation [0.03%]
趋向虚拟凝集研究
Fazoil I Ataullakhanov,Mikhail A Panteleev
Fazoil I Ataullakhanov