Gene structures of trocarin D and coagulation factor X, two functionally diverse prothrombin activators from Australian rough scaled snake [0.03%]
来自澳大利亚鳞背蛇的两种功能迥异的凝血酶原激活剂trocarin D和因子X的基因结构
M Abu Reza,Sanjay Swarup,R Manjunatha Kini
M Abu Reza
Activation of prothrombin to thrombin is the key reaction in blood coagulation cascade. We have recently shown that Australian rough scaled snake, Tropidechis carinatus, possesses two parallel prothrombin activator systems. Trocarin D, a ve...
Serine proteases affecting blood coagulation and fibrinolysis from snake venoms [0.03%]
蛇毒中影响血液凝固和纤维蛋白溶解的丝氨酸蛋白酶
R Manjunatha Kini
R Manjunatha Kini
Snake venom proteases, in addition to their contribution to the digestion of the prey, affect various physiological functions. They affect platelet aggregation, blood coagulation, fibrinolysis, complement system, blood pressure and nervous ...
C-terminal heparin-binding peptide of snake venom VEGF specifically blocks VEGF-stimulated endothelial cell proliferation [0.03%]
CobraVEGF的C末端肝素结合肽可特异性阻断VEGF刺激的内皮细胞增殖作用
Yasuo Yamazaki,Yuko Tokunaga,Koji Takani et al.
Yasuo Yamazaki et al.
Vascular endothelial growth factor-A165 (VEGF-A165) exhibits diverse biological effects through binding to its receptor KDR (VEGFR-2). Heparin-like molecules are known to modulate their interaction. There have been reports that VEGF-A lacki...
Identification and localization of heparin-binding region of snake venom VEGF and its blocking of VEGF-A165 [0.03%]
蛇毒VEGF的肝素结合区的鉴定及定位及其对VEGF-A165的功能抑制作用
Yuko Tokunaga,Yasuo Yamazaki,Takashi Morita
Yuko Tokunaga
Vascular endothelial growth factor (VEGF-A165) displays diverse effects through binding to its receptor, KDR (kinase domain-containing receptor). Heparan sulfate/heparin-like molecules greatly contribute to their interaction. Indeed, the mi...
Comparison of textilinin-1 with aprotinin as serine protease inhibitors and as antifibrinolytic agents [0.03%]
文本比较纺织素-1和氨基葡萄糖作为丝氨酸蛋白酶抑制剂和抗纤维蛋白溶解剂的效果
Simone Flight,Lambro Johnson,Manuela Trabi et al.
Simone Flight et al.
Textilinin-1 (Q8008) was isolated from the venom of the Pseudonaja textilis and has a 47% sequence identity to the antihaemorrhagic therapeutic agent aprotinin. When equimolar concentrations of enzyme and aprotinin were pre-incubated, plasm...
Comparative Study
Pathophysiology of haemostasis and thrombosis. 2005;34(4-5):188-93. DOI:10.1159/000092421 2005
Hemextin AB complex--a snake venom anticoagulant protein complex that inhibits factor VIIa activity [0.03%]
抑制凝血因子VIIa活性的蛇毒抗凝蛋白复合物HemextinAB複合物
Yajnavalka Banerjee,Jun Mizuguchi,Sadaaki Iwanaga et al.
Yajnavalka Banerjee et al.
Snake venom is a veritable gold mine of bioactive molecules, capable of binding to a wide variety of pharmacological targets, including the blood coagulation cascade. Here, we report the isolation and characterization of two synergistically...
Development of a novel recombinant disintegrin, contortrostatin, as an effective anti-tumor and anti-angiogenic agent [0.03%]
新型重组蛋白整合素contortrostatin的开发及其作为抗肿瘤和抗血管生成剂的有效性研究
Radu Minea,Stephen Swenson,Fritz Costa et al.
Radu Minea et al.
Contortrostatin (CN) (Mr 13,500 Da) is a novel homodimeric disintegrin isolated from the venom of Agkistrodon contortrix contortrix (Southern Copperhead) snake and displays two RGD motifs (one on each chain), which modulate its interaction ...
Contortrostatin, a snake venom disintegrin with anti-angiogenic and anti-tumor activity [0.03%]
一种具有抗血管生成和抗肿瘤活性的蛇毒金属蛋白酶抑制剂
Stephen Swenson,Fritz Costa,William Ernst et al.
Stephen Swenson et al.
Disintegrins are soluble peptides found in snake venom. They bind to Arg-Gly-Asp (RGD)-responsive integrins with high affinity (nM range) and block integrin function. Contortrostatin (CN), the disintegrin from southern copperhead venom, is ...
Scratching below the surface: wound healing and alanine mutagenesis provide unique insights into interactions between eristostatin, platelets and melanoma cells [0.03%]
由伤口愈合和丙氨酸诱变提供独特的见解探讨色胺与血小板及黑色素瘤细胞间的相互作用
Mary Ann McLane,Xiaoming Zhang,Jing Tian et al.
Mary Ann McLane et al.
To study the molecular mechanism of the disintegrin eristostatin, cellular functional studies were performed using ten recombinant alanine mutants. ADP-induced platelet aggregation revealed critical contributions of seven residues within th...
Bothrojaracin, a Bothrops jararaca snake venom-derived (pro)thrombin inhibitor, as an anti-thrombotic molecule [0.03%]
来源于 Bothrops jararaca 眼镜蛇毒液的 Bothrojaracine（一种无活性）前 thrombin 抑制剂是一种抗凝血分子
Russolina B Zingali,Marcos S Ferreira,Mariane Assafim et al.
Russolina B Zingali et al.
Bothrojaracin (BJC) is a selective and potent thrombin inhibitor (KD = 0.6 nM) which also binds to prothrombin on proexosite I (KD = 175 nM). Incubation of BJC with human or rat plasma produced a band that co-migrates with purified prothrom...