Akihiro Ihara,Kengo Matsumoto,Toshiharu Kawamoto et al.
Akihiro Ihara et al.
The purpose of this study was to investigate whether platelet indexes [platelet count, mean platelet volume (MPV), platelet-large cell ratio (P-LCR), and platelet distribution width (PDW)] could serve as diagnostic tools to evaluate the pot...
Combinations of low doses of unfractionated heparin and of low-molecular-weight heparin prevent experimental venous thrombosis [0.03%]
低剂量普通肝素与低分子量肝素组合预防实验性静脉血栓形成
Guareide Carelli,Francisco H A Maffei,Luci Mattar et al.
Guareide Carelli et al.
Synergism between low-molecular-weight heparin and low doses of unfractionated heparin (UH) enhancing anti-factor Xa activity and the release of tissue factor pathway inhibitor was observed. The aim of this study was to verify whether this ...
The extent of platelet activation under shear depends on platelet count: differential expression of anionic phospholipid and factor Va [0.03%]
剪切下血小板活化的程度取决于血小板数目：负电性磷脂和因子Va的差异表达
Katherine Schulz-Heik,Jaimohan Ramachandran,Danny Bluestein et al.
Katherine Schulz-Heik et al.
It is widely accepted that shear stress activates platelets. However, this may have two linked but separate causes: a direct effect of shear stress on individual platelets, and secondary inter-platelet activation dependent on the release of...
Davide Imberti,Walter Ageno
Davide Imberti
Background: Venous thromboembolism (VTE) is a common life-threatening complication of major trauma. Although clinical guidelines clearly suggest routine VTE prevention with low-molecular-weight heparin (LMWH) in this spec...
The potential of Bothrops moojeni venom in the field of hemostasis. Established use and new insights [0.03%]
Bothrops moojeni蛇毒在凝血领域的潜力。 established使用和新的见解
Anna Maria Perchuć,Laure Menin,Reto Stocklin et al.
Anna Maria Perchuć et al.
Early studies in the 1930s on the venom of South American Lancehead snakesofthe Bothrops genuslead to the discovery of compounds active in blood coagulation such as batroxobin and botrocetin. The scope of our investigations is to have a dee...
The use of snake venom-derived compounds for new functional diagnostic test kits in the field of haemostasis [0.03%]
蛇毒衍生化合物在血液凝固功能诊断试剂盒中的应用
Reto Schoni
Reto Schoni
Pentapharm Ltd. has a long tradition of producing and proceeding snake venom components as APIs and tools in pharmaceutical and diagnostic applications, beginning with the snake venom-derived product Reptilase about 60 years ago. In recent ...
Exploring new molecules and activities from Lonomia obliqua caterpillars [0.03%]
从Lonomia obliqua caterpillars中探索新的分子和活性
Ana Marisa Chudzinski-Tavassi,Miryam Paola Alvarez Flores
Ana Marisa Chudzinski-Tavassi
Skin contact with Lonomia caterpillar bristles causes a consumptive coagulopathy. From a cDNA library we cloned and expressed a prothrombin activator (rLopap) in active form, and from the bristles extract we characterized a FX activator (Lo...
Donald E Champagne
Donald E Champagne
The ability to feed on vertebrate blood has evolved many times in various arthropod clades. Each time this trait evolves, novel solutions to the problem posed by vertebrate hemostasis are generated. Consequently, saliva of blood-feeding art...
Non-clinical and clinical characterization of a novel acting thrombolytic: alfimeprase [0.03%]
新型溶栓药物alfimeprase的非临床和临床特征分析
Steven R Deitcher,Christopher F Toombs
Steven R Deitcher
Alfimeprase (ALF) is a recombinant, truncated form of fibrolase, a directly fibrinolytic zinc metalloproteinase that was first isolated from the venom of the Southern copperhead snake (Agkistrodon contortrix contortrix). ALF has direct prot...
Vipera lebetina venom contains all types of snake venom metalloproteases [0.03%]
黎贝蒂娜蝰蛇毒液含有所有类型的蛇毒金属蛋白酶
J Siigur,K Tõnismagi,K Trummal et al.
J Siigur et al.
Snake venoms contain four classes of metalloproteases that all have a typical zinc-chelating sequence (HEXXHGXXH). N-terminal sequences and internal sequences of different purified metalloproteases were determined using Edman sequencing and...