Frederick R Rickles
Frederick R Rickles
Substantial epidemiologic, laboratory, pathologic and clinical evidence supports the historic association between activation of blood coagulation and progression of cancer. The increased risk for venous thromboembolism(VTE) in cancer has be...
The role of ADAMT-13 in platelet adhesion in flow: methods for diagnosis of thrombotic thrombocytopenic purpura [0.03%]
ADAMT-13在流动中血小板黏附中的作用及对特发性血小板减少性紫癜的诊断方法研究
Boris Shenkman
Boris Shenkman
Von willebrand factor (VWF) is synthesized and released from endothelial cells and megakaryocytes. VWF multimers that are immobilized on the activated endothelial cells and unfolded by high shear stress, undergo proteolysis by specific VWF-...
Thrombotic thromboytopenic purpura: another example of immunomediated thrombosis [0.03%]
血小板减少性紫癜：免疫介导的血栓形成作用的另一例证
Pier Mannuccio Mannucci
Pier Mannuccio Mannucci
Much progress has been made in recent years in understanding the mechanisms of TTP, through the demonstration of the role of ultra-large von Willebrand factor multimers and of ADAMTS13 deficiency in the pathogenesis of immune-mediated and g...
Impact--the cone and plate(let) analyzer: testing platelet function and anti-platelet drug response [0.03%]
影响——圆锥和盘式血小板功能及抗血小板药物反应分析仪
Naphtali Savion,David Varon
Naphtali Savion
The Impact [cone and plate(let) analyzer (CPA) Technology]is testing whole blood platelet adhesion and aggregation under arterial flow conditions. The adhered platelets are stained and the percentage of surface covered (SC) by the stained o...
Alan D Michelson
Alan D Michelson
Marc Ribo,Carlos A Molina
Marc Ribo
Manipulation of endogenous neural stem cells following ischemic brain injury [0.03%]
缺血性脑损伤后操纵内源性的神经干细胞
Ronen R Leker
Ronen R Leker
The use of cell-based therapy is a valid therapeutic approach to ischemic brain injury. Endogenous neural stem cells (NSCs) have been identified in the central nervous system where they reside largely in the subventricular zone and in the s...
HIT: lessons learned [0.03%]
_HIT：经验与教训_
Theodore E Warkentin
Theodore E Warkentin
The peculiar pathogenesis of heparin-induced thrombocytopenia (HIT), involving a "self" antigen-platelet factor 4 (PF4) bound to heparin-and resulting antibody-mediated platelet activation, is a model for thrombosis triggered by drug-induce...
The role of surface PF4: glycosaminoglycan complexes in the pathogenesis of heparin-induced thrombocytopenia (HIT) [0.03%]
表面PF4-糖胺聚糖复合体在肝素诱导的血小板减少症(HIT)发病机制中的作用
Mortimer Poncz,Lubica Rauova,Douglas B Cines
Mortimer Poncz
Andreas Greinacher
Andreas Greinacher
Heparin-induced thrombocytopenia (HIT) is a life- and limb-threatening prothrombotic, immune-mediated adverse drug effect that occurs with unfractionated heparin and to a lesser extent with low molecular weight heparin. HIT results from a p...