Lipoprotein(a) and thrombocytes: potential mechanisms underlying cardiovascular risk [0.03%]
脂蛋白(a)和血小板：心血管风险的潜在机制
William Discepolo,Ted Wun,Lars Berglund
William Discepolo
Plasma levels of lipoprotein(a), Lp(a), is an independent risk factor for cardiovascular disease. Lp(a) has many properties in common with low-density lipoprotein (LDL), including a cholesteryl ester-rich lipid core and the presence of one ...
Suzanne J A Korporaal,Jan-Willem N Akkerman
Suzanne J A Korporaal
Platelets and lipoproteins are both key elements in the development of atherosclerosis and thrombosis. Based on their density, five classes of lipoproteins have been identified which all influence platelets via distinct mechanisms. The acti...
Platelet interaction with bioactive lipids formed by mild oxidation of low-density lipoprotein [0.03%]
低密度脂蛋白轻度氧化形成的生物活性脂质与血小板的相互作用
Wolfgang Siess
Wolfgang Siess
Oxidation of low-density lipoprotein (LDL) generates pro-inflammatory and pro-thrombotic mediators that play a crucial role in cardiovascular and inflammatory diseases. Mildly oxidized LDL (mox-LDL) and minimally modified LDL (mm-LDL) which...
Rasaq Olufadi,Christopher D Byrne
Rasaq Olufadi
There is a considerable body of evidence supporting an association between hypertriglyceridaemia, a hypercoagulable state and atherothrombosis. A disorder of triglyceride metabolism is a key feature of the metabolic syndrome that increases ...
Platelet activation by low density lipoprotein and high density lipoprotein [0.03%]
低密度脂蛋白和高密度脂蛋白对血小板的活化作用
Suzanne J A Korporaal,Jan-Willem N Akkerman
Suzanne J A Korporaal
Cardiovascular disease is the main cause of death and disability in the Western society. Lipoproteins are important in the development of cardiovascular disease since they change the properties of different cells involved in atherosclerosis...
Marguerite Neerman-Arbez
Marguerite Neerman-Arbez
Inherited fibrinogen disorders can be classified into qualitative and quantitative anomalies: dysfibrinogenemia is characterised by normal circulating levels of fibrinogen with abnormal function; hypofibrinogenemia and afibrinogenemia are c...
Richard Cervera,Ronald A Asherton
Richard Cervera
The catastrophic antiphospholipid syndrome is a potentially life-threatening condition with a high mortality, which requires a high degree of clinical awareness on the part of attending physicians. Patients with this syndrome have in common...
Vittorio Pengo,Amelia Ruffatti,Sabino Iliceto
Vittorio Pengo
The concurrence of antiphospholipid (aPL) antibodies and thrombosis or pregnancy loss defines the 'antiphospholipid syndrome' (APS). The Sydney update of the classification criteria for definite APS diagnosis introduced numerous amelioratio...
Gerd Schmitz,Christian M Schambeck
Gerd Schmitz
Platelet function is sensitive to alterations in cholesterol metabolism, and hypercholesterolemia is associated with enhanced platelet reagibility. Atherogenic low-density lipoproteins (LDL), in particular oxidized LDL, activate src-kinase-...
Role of coagulation factor XIII (FXIII) in angiogenesis and tissue repair [0.03%]
凝血因子FXIII在血管生成和组织修复中的作用
Aida Inbal,Rima Dardik
Aida Inbal
Factor FXIII (FXIII) is a plasma transglutaminase that catalyzes the cross link formation between fibrin chains to stabilize the clot. Beside it s function in hemostasis FXIII has a role in wound healing and embryo implantation--processes t...